Piezoelectric nanogenerators for personalized healthcare

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(9), P. 3380 - 3435

Published: Jan. 1, 2022

Piezoelectric nanogenerators are becoming a compelling bioelectronics platform technology for human-associated energy harvesting, self-powered sensing, and therapeutics, which will largely contribute to the medical field in era of Internet things.

Language: Английский

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Piezocatalytic Medicine: An Emerging Frontier using Piezoelectric Materials for Biomedical Applications

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(25)

Published: Jan. 12, 2023

Abstract Emerging piezocatalysts have demonstrated their remarkable application potential in diverse medical fields. In addition to ultrahigh catalytic activities, inherent and unique charge‐carrier‐releasing properties can be used initiate various redox reactions, displaying bright prospects for future applications. Triggered by mechanical energy, piezocatalytic materials release electrons/holes, catalyze reactions of substrates, or intervene biological processes promote the production effector molecules purposes, such as decontamination, sterilization, therapy. Such a piezocatalysis is termed medicine (PCM) herein. To pioneer novel technologies, especially therapeutic modalities, this review provides an overview state‐of‐the‐art research progress medicine. First, principle preparation methodologies piezoelectric are introduced. Then, comprehensive summary applications tumor treatment, antisepsis, organic degradation, tissue repair regeneration, biosensing provided. Finally, main challenges perspectives discussed proposed, expecting fuel development emerging scientific discipline.

Language: Английский

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Selective Enhancement of Photo‐Piezocatalytic Performance in BaTiO₃ Via heterovalent Ion Doping

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(52)

Published: Oct. 17, 2022

Abstract This study proposes a strategy based on heterovalent ion doping that gives rise to synergistic piezo‐phototronic effect with significantly improved catalytic activity and leads selective enhancement for specific pollutants. Owing the enhanced light absorption, hydrogen evolution rates are as high 3704 3178 µmolg −1 h in 0.01Li‐doped BaTiO 3 0.02La‐doped nanosheets, respectively, under simultaneous irradiation by ultrasound light, factor of 4.6 3.9 times higher than pure . The performance also far exceeds single piezocatalysis, photocatalysis, or sum two Li/La‐doped nanosheets due effects piezoelectric field promoting photo‐induced separation electron‐hole pairs. Further, carefully selecting donor acceptor doping, significant catalyst pollutants is obtained controlling band structure. Compared , possesses anionic dyes such Methyl blue Malachite Green, reaching 0.067 1.379 min while exhibits better cationic Rhodamine B Orange, degradation up 0.274 0.029 respectively. offers path design efficient piezocatalysts applications.

Language: Английский

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Nanomedicine‐Enabled Sonomechanical, Sonopiezoelectric, Sonodynamic, and Sonothermal Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(31)

Published: Feb. 22, 2023

Abstract Nanomedicine‐enabled/augmented ultrasound (US) medicine is a unique area of interdisciplinary research that focuses on designing and engineering functional nanosystems to address the challenging issues in US‐based biomedicine, overcoming shortcomings traditional microbubbles optimizing design contrast sonosensitive agents. The single‐faceted summary available US‐related therapies still significant drawback. Here, proposal comprehensive review recent advances nanomaterials advancing four biological applications disease theranostics aimed. In addition mostly explored nanomedicine‐enabled/augmented sonodynamic therapy (SDT), discussion other sono‐therapies progresses/achievements are relatively lacking, including sonomechanical (SMT), sonopiezoelectric (SPT), sonothermal (STT). concepts specific based nanomedicines initially introduced. Furthermore, representative paradigms for nanomedicine‐enabled/enhanced US elaborated according therapeutic principles diversity. This provides an updated field nanoultrasonic comprehensively discusses progress versatile ultrasonic treatments. Finally, deep facing challenges prospects expected promote emergence establishment new branch biomedicine through rational combination nanomedicine clinical biomedicine.

Language: Английский

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Piezoelectric Metal–Organic Frameworks Based Sonosensitizer for Enhanced Nanozyme Catalytic and Sonodynamic Therapies

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7901 - 7910

Published: April 13, 2023

The regulation of electrostatic electric fields through electrical stimulation is an efficient method to increase the catalytic activity nanozymes and improve therapeutic effect nanozyme therapy. Piezoelectric materials, which are capable generating a built-in field under ultrasound (US), not only but also enable piezoelectric sonodynamic therapy (SDT). In this study, sonosensitizer based on Hf-based metal–organic framework (UIO-66) Au nanoparticles (NPs) was produced. Under US irradiation, UIO-66 can generate inside promotes electron–hole separation produces reactive oxygen species (ROS). introduction NPs facilitated electron transfer, inhibited recombination pairs improved properties UIO-66. value constant (d33) increased from 71 122 pmV–1 after deposition NPs. addition, intrinsic catalase peroxidase activities were 2-fold induced exposure. vivo in vitro experiments revealed that proposed kill cancer cells inhibit tumor growth mice enhanced SDT sensitizer work proved be candidate used for multiple modalities

Language: Английский

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Oxygen‐Vacancy‐Rich Piezoelectric BiO_2−x Nanosheets for Augmented Piezocatalytic, Sonothermal, and Enzymatic Therapies

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(29)

Published: April 14, 2023

Abstract Piezocatalytic therapy is a new‐emerging reactive oxygen species (ROS)‐enabled therapeutic strategy that relies on built‐in electric field and energy‐band bending of piezoelectric materials activated by ultrasound (US) irradiation. Despite becoming hot topic, material development mechanism exploration are still underway. Herein, as‐synthesized oxygen‐vacancy‐rich BiO 2− x nanosheets (NSs) demonstrate outstanding properties. Under US, piezo‐potential 0.25 V for NSs sufficient to tilt the conduction band be more negative than redox potentials O 2 / • − , /H H OH, which initiates cascade reaction ROS generation. Moreover, exhibit peroxidase oxidase‐like activities augment production, especially in ‐overexpressed tumor microenvironment. Density functional theory calculations show generated vacancies favorable adsorption increasing carrier density produce ROS. Furthermore, quick movement electrons enables an excellent sonothermal effect, example, rapid rise temperature nearly 65 °C upon US with low power (1.2 W cm −2 ) short time (96 s). Therefore, this system realizes multimode synergistic combination piezocatalytic, enzymatic, therapies, providing new direction defect engineering‐optimized therapy.

Language: Английский

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Design strategies and effect comparisons toward efficient piezocatalytic system

Nano Energy, Journal Year: 2022, Volume and Issue: 107, P. 108093 - 108093

Published: Dec. 15, 2022

Language: Английский

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Doping Engineering to Modulate Lattice and Electronic Structure for Enhanced Piezocatalytic Therapy and Ferroptosis

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(38)

Published: July 12, 2023

Piezocatalytic therapy, which generates reactive oxygen species (ROS) under mechanical force, has garnered extensive attention for its use in cancer therapy owing to deep tissue penetration depth and less O2 -dependence. However, the piezocatalytic therapeutic efficiency is limited poor piezoresponse, low separation of electron-hole pairs, complicated tumor microenvironment (TME). Herein, a biodegradable, porous Mn-doped ZnO (Mn-ZnO) nanocluster with enhanced piezoelectric effect constructed via doping engineering. Mn-doping not only induces lattice distortion increase polarization but also creates rich vacancies (OV ) suppressing recombination leading high-efficiency generation ROS ultrasound irradiation. Moreover, shows TME-responsive multienzyme-mimicking activity glutathione (GSH) depletion ability mixed valence Mn (II/III), further aggravating oxidative stress. Density functional theory calculations show that can improve performance enzyme Mn-ZnO due presence OV . Benefiting from boosting GSH ability, significantly accelerate accumulation lipid peroxide inactivate peroxidase 4 (GPX4) induce ferroptosis. The work may provide new guidance exploring novel sonosensitizers therapy.

Language: Английский

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Piezotronic and piezo‐phototronic effects on sonodynamic disease therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 18, 2023

Abstract With the development of engineered nanomaterials and nanomedicines, utilization to generate excessive reactive oxygen species under exogenous ultrasound (US) irradiation for realizing disease therapy, namely sonodynamic therapy (SDT), has attracted widespread attention. Compared with traditional photodynamic US shows deeper tissue penetration reach deep‐seated location. However, high‐efficiency sonosensitizers remains one gravest challenges in current related research future clinical application. Latterly, benefiting from piezotronic piezo‐phototronic effects, novel based on piezoelectric semiconductor (PS) have exhibited inspiring application prospects SDT. In this review, we outline structures physicochemical properties PS that potential applications SDT, introduce presumed mechanisms Then, latest progress as cancer antibacterial are summarized. Finally, existing trends field prospected.

Language: Английский

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One-dimensional nanomaterials for cancer therapy and diagnosis

Chemical Society Reviews, Journal Year: 2023, Volume and Issue: 52(13), P. 4488 - 4514

Published: Jan. 1, 2023

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D can be classified according to their shape, such nanorods, nanotubes, nanowires, self-assembled nanochains, etc., have been applied in electronics, photonics, catalysis. The biological characteristics of nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability capture cancer cells, cellular uptake mechanisms, efficient photothermal conversion, material tunability, aided extending potential biomedical applications, particularly therapy diagnosis. This review highlights a novel perspective on emerging diagnosis by introducing definition physicochemical properties, recent advances also proposes unexplored nanomaterial types therapeutic applications nanomaterials. In particular, most significant exciting years, ultrasound-enabled sonodynamic therapy, magnetic field-based bioresponsive intracellular self-assembly situ, discussed along with concepts, piezoelectric nanozyme-based nanomedicine, others.

Language: Английский

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