Polymers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 664 - 664
Published: Feb. 29, 2024
Nanofibrous
materials
represent
a
very
promising
form
of
advanced
carrier
systems
that
can
be
used
industrially,
especially
in
regenerative
medicine
as
highly
functional
bandages,
or
wound
dressings.
By
incorporation
antimicrobial
additives
directly
into
the
structure
nanofiber
carrier,
functionality
layer
is
upgraded,
depending
on
final
requirement-bactericidal,
bacteriostatic,
antiseptic,
generally
effect.
Such
nanofibrous
layers
prepared
mostly
by
electrospinning
technology
from
both
synthetic
and
natural
polymers.
The
presence
polymer
composition
advantageous.
Especially
medical
applications
where,
due
to
material
close
human
body,
healing
process
more
efficient
without
occurrence
an
unwanted
inflammatory
response.
However,
converting
polymers
form,
with
homogeneously
distributed
stable
additive,
great
challenge.
Thus,
combination
often
used.
This
review
clearly
summarizes
issue
effectiveness
different
types
substances,
such
nanoparticles,
antibiotics,
common
antiseptics,
substances
origin,
electrospun
made
materials.
A
section
describing
problematic
aspects
also
included.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 1, 2024
Metal-organic
frameworks
(MOFs)
are
metal-organic
skeleton
compounds
composed
of
self-assembled
metal
ions
or
clusters
and
organic
ligands.
MOF
materials
often
have
porous
structures,
high
specific
surface
areas,
uniform
adjustable
pores,
activity
easy
modification
a
wide
range
prospects
for
application.
MOFs
been
widely
used.
In
recent
years,
with
the
continuous
expansion
materials,
they
also
achieved
remarkable
results
in
field
antimicrobial
agents.
this
review,
structural
composition
synthetic
introduced
detail,
mechanisms
applications
these
healing
infected
wounds
described.
Moreover,
opportunities
challenges
encountered
development
presented,
we
expect
that
additional
biosafety
efficient
capacity
will
be
developed
future.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(5), P. 052001 - 052001
Published: July 8, 2024
Abstract
Wound
healing
is
a
critical
but
complex
biological
process
of
skin
tissue
repair
and
regeneration
resulting
from
various
systems
working
together
at
the
cellular
molecular
levels.
Quick
wound
problems
associated
with
traditional
techniques
are
being
overcome
multifunctional
materials.
Over
time,
this
research
area
has
drawn
significant
attention.
Metal-organic
frameworks
(MOFs),
owning
to
their
peculiar
physicochemical
characteristics,
now
considered
promising
class
well-suited
porous
materials
for
in
addition
other
applications.
This
detailed
literature
review
provides
an
overview
latest
developments
MOFs
We
have
discussed
synthesis,
essential
biomedical
properties,
wound-healing
mechanism,
MOF-based
dressing
materials,
The
possible
major
challenges
limitations
been
discussed,
along
conclusions
future
perspectives.
addresses
MOFs-based
several
angles
covers
most
current
subject.
readers
may
discover
how
advanced
discipline
by
producing
more
inventive,
useful,
successful
dressings.
It
influences
development
generations
biomaterials
wounds.
BioFactors,
Journal Year:
2023,
Volume and Issue:
49(4), P. 736 - 781
Published: March 24, 2023
Abstract
Despite
numerous
advantages,
curcumin's
(CUR)
low
solubility
and
bioavailability
limit
its
employment
as
a
free
drug.
CUR‐incorporated
nanoformulation
enhances
the
angiogenesis,
collagen
deposition,
fibroblast
proliferation,
reepithelization,
synthesis,
neovascularization,
granulation
tissue
formation
in
different
wounds.
Designing
nanoformulations
with
controlled‐release
properties
ensure
presence
of
CUR
defective
area
during
treatment.
Different
encompassing
nanofibers,
nanoparticles
(NPs),
nanospray,
nanoemulsion,
nanosuspension,
nanoliposome,
nanovesicle,
nanomicelle
were
described
present
study
comprehensively.
Moreover,
for
some
other
systems
which
contain
nano‐CUR
or
nanoformulations,
including
films,
composites,
scaffolds,
gel,
hydrogels
seems
CUR‐loaded
NPs
incorporation
has
better
control
sustained
release,
thereby,
until
final
stages
wound
healing
is
more
possible.
Incorporating
chitosan
into
nanofiber
increased
release
time,
while
80%
was
released
240
h
(10
days).
Therefore,
this
system
can
guarantee
entire
period.
Furthermore,
porous
structures
such
sponges,
aerogels,
hydrogels,
scaffolds
disclosed
promising
performance.
These
architectures
interconnected
pores
mimic
native
extracellular
matrix,
thereby
facilitating
attachment
infiltration
cells
at
site,
besides
maintaining
flow
nutrients
oxygen
within
three‐dimensional
structure
essential
rapid
proper
healing,
well
enhancing
mechanical
strength.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(5), P. 1521 - 1521
Published: May 17, 2023
Metal-organic
frameworks
(MOFs)
are
a
highly
versatile
class
of
ordered
porous
materials,
which
hold
great
promise
for
different
biomedical
applications,
including
antibacterial
therapy.
In
light
the
effects,
these
nanomaterials
can
be
attractive
several
reasons.
First,
MOFs
exhibit
high
loading
capacity
numerous
drugs,
antibiotics,
photosensitizers,
and/or
photothermal
molecules.
The
inherent
micro-
or
meso-porosity
MOF
structures
enables
their
use
as
nanocarriers
simultaneous
encapsulation
multiple
drugs
resulting
in
combined
therapeutic
effect.
addition
to
being
encapsulated
into
an
MOF's
pores,
agents
sometimes
directly
incorporated
skeleton
organic
linkers.
Next,
contain
coordinated
metal
ions
structure.
Incorporation
Fe
Nanotechnology Reviews,
Journal Year:
2023,
Volume and Issue:
12(1)
Published: Jan. 1, 2023
Abstract
The
repair
and
remodeling
of
injured
tissues,
known
as
wound
healing,
is
a
multifaceted
process.
use
nanotechnology
to
speed
up
the
healing
process
wounds
by
promoting
right
kind
mobility
through
different
mechanisms
has
shown
lot
promise.
Several
nanotechnologies
with
novel
properties
have
emerged
in
recent
years,
each
which
targets
issue
associated
wound-healing
processes.
Through
their
antibacterial,
anti-inflammatory,
angiogenic
actions,
nanomaterials
may
alter
microenvironment
from
non-healing
state.
Wound
dressings
including
hydrogels,
gelatin
sponges,
films,
bandages
all
benefit
nanoparticles
(NPs)
keep
harmful
microbes
out.
addition
bioactive
substances
like
antibiotics,
NPs,
growth
factors
certain
further
boost
efficacy.
In
conclusion,
this
review
sheds
light
on
that
be
aided
special
features
materials
based
nanotechnology.
Although
for
show
great
promise,
study
needed
before
promising
area
can
convert
its
findings
into
consumer-friendly
solutions.
Bioactive Materials,
Journal Year:
2024,
Volume and Issue:
41, P. 174 - 192
Published: July 20, 2024
Hemostatic
materials
are
essential
for
managing
acute
bleeding
in
medical
settings.
Chitosan
(CS)
shows
promise
hemostasis
but
its
underlying
mechanism
remains
incompletely
understood.
We
unexpectedly
discovered
that
certain
protonated-chitosan
(PCS)
rapidly
assembled
plasma
proteins
to
form
protein
membrane
(PM)
upon
contact
with
platelet-poor
(PPP).
hypothesized
the
novel
observation
was
intricately
related
procoagulant
effect
of
chitosan.
Herein,
study
aimed
elucidate
conditions
necessary
and
PM
formation,
identify
within
PCS's
action
at
molecule
levels.
confirmed
amount
-NH
