APL Materials,
Journal Year:
2024,
Volume and Issue:
12(5)
Published: May 1, 2024
Gene
therapy
has
been
extensively
investigated
and
widely
used
in
biomedical
fields,
such
as
cancer
treatment.
However,
the
most
important
issues
for
gene
are
stability,
targeting
effect,
transfection
efficacy,
safety
of
formulation
after
administration,
which
seriously
limit
further
application
clinic.
Therefore,
delivery
could
be
a
promising
strategy
overcoming
these
challenges.
Two-dimensional
(2D)
materials
rising
nanomaterials
with
excellent
physical
chemical
properties,
including
large
specific
surface
area,
easy
modification,
high
conversion
efficiency
light,
good
biocompatibility,
have
achieved
applications
vehicles
disease
In
this
review,
we
first
summarized
research
progress
2D
material-based
nanosystems
to
improve
therapeutic
efficacy.
We
discussed
that
showed
efficacy
many
diseases
treatment,
especially
cancer.
Furthermore,
also
proposed
modification
might
prepare
multi-functional
carriers
combination
enhanced
treatment
Finally,
future
progress,
challenges,
prospects
were
concluded.
Conclusively,
believe
biocompatibility
would
potentially
clinical
settings
therapy.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
351, P. 50 - 80
Published: Sept. 20, 2022
The
site-specific
delivery
of
antitumor
agents
is
importance
for
providing
effective
cancer
suppression.
Poor
bioavailability
anticancer
compounds
and
the
presence
biological
barriers
prevent
their
accumulation
in
tumor
sites.
These
obstacles
can
be
overcome
using
liposomal
nanostructures.
challenges
chemotherapy
stimuli-responsive
nanocarriers
are
first
described
current
review.
Then,
liposomes
including
pH-,
redox-,
enzyme-,
light-,
thermo-
magneto-sensitive
nanoparticles
discussed
potential
drugs
emphasized.
pH-
or
redox-sensitive
based
on
internal
stimulus
release
drug
response
to
a
mildly
acidic
pH
GSH,
respectively.
pH-sensitive
mediate
endosomal
escape
via
proton
sponge.
multifunctional
responsive
both
redox
have
more
capacity
at
site
compared
alone.
magnetic
field
NIR
irradiation
exploited
external
stimulation
liposomes.
light-responsive
when
they
exposed
irradiation;
thermosensitive-liposomes
temperature
>40
°C
there
hyperthermia;
magneto-responsive
field.
smart
nanoliposomes
also
co-delivery
genes
synergistic
therapy.
Due
lack
long-term
toxicity
liposomes,
utilized
near
future
treatment
patients.
Pharmacological Research,
Journal Year:
2022,
Volume and Issue:
187, P. 106553 - 106553
Published: Nov. 16, 2022
Cancer
progression
results
from
activation
of
various
signaling
networks.
Among
these,
PI3K/Akt
contributes
to
proliferation,
invasion,
and
inhibition
apoptosis.
Hepatocellular
carcinoma
(HCC)
is
a
primary
liver
cancer
with
high
incidence
rate,
especially
in
regions
prevalence
viral
hepatitis
infection.
Autoimmune
disorders,
diabetes
mellitus,
obesity,
alcohol
consumption,
inflammation
can
also
lead
initiation
development
HCC.
The
treatment
HCC
depends
on
the
identification
oncogenic
factors
that
tumor
cells
develop
resistance
therapy.
present
review
article
focuses
role
progression.
Activation
promotes
glucose
uptake,
favors
glycolysis
increases
cell
proliferation.
It
inhibits
both
apoptosis
autophagy
while
promoting
survival.
stimulates
epithelial-to-mesenchymal
transition
(EMT)
matrix-metalloproteinase
(MMP)
expression
during
metastasis.
In
addition
increasing
colony
formation
capacity
facilitating
spread
cells,
angiogenesis.
Therefore,
silencing
prevents
aggressive
behavior.
confer
drug
resistance,
particularly
sorafenib,
decreases
radio-sensitivity
cells.
Anti-cancer
agents,
like
phytochemicals
small
molecules
suppress
by
limiting
Being
upregulated
tissues
clinical
samples,
be
used
as
biomarker
predict
patients'
response
Advanced Composites and Hybrid Materials,
Journal Year:
2023,
Volume and Issue:
6(1)
Published: Jan. 31, 2023
Abstract
Bio-responsive
nanocomposites
with
facile
fabrication
and
rational
design
are
of
great
importance
in
the
diagnosis
treatment
cancer.
Herein,
combination
bioimaging
due
to
presence
QD
controlled
drug
delivery
via
nanogel
was
employed
for
cancer
treatment.
To
this
aim,
we
fabricated
a
traceable
bioresponsive
fluorescent
active
composite
by
integrating
creatinine-functionalized
carbon
dots
(QD)
into
lecithin-inulin
nanogel.
Subsequently,
PEGylation
integration
herceptin
on
were
carried
out
improve
biofate
its
ability
target
HER2-positive
breast
The
assessment
cellular
uptake
demonstrated
that
effectively
internalized
SK-BR-3
cells
production
reactive
oxygen
species
significantly
boosted.
Moreover,
led
high
expression
P53
Bax
genes
along
low
Bcl-2
gene
(as
promotors
apoptosis
signaling
pathway).
enhanced.
It
inhibiting
proliferation
as
well
reduction
viability
(HER-2
positive)
compared
MDA-MB-231
(triple-negative).
intraperitoneal
injection
developed
formulation
MCF-7
cell-bearing
BALB/c
mice
supported
observation
tumor
growth
inhibition.
Overall,
herceptin-adorned
PEGylated
can
be
promising
theranostic
candidate
targeting
HER-2-positive
Graphical
Advanced Composites and Hybrid Materials,
Journal Year:
2024,
Volume and Issue:
7(1)
Published: Jan. 22, 2024
Abstract
The
present
study
proposed
an
innovative
nanocomposite
aimed
at
enhancing
gene
and
drug
delivery
for
cancer
treatment.
was
composed
of
amine-functionalized
metal–organic
frameworks,
(NH
2
)-MIL-125(Ti),
conjugated
to
poly(aniline-
co
-para-phenylenediamine),
coated
on
manganese
ferrite
nanoparticles
that
were
utilized
co-deliver
the
chemotherapy
doxorubicin
(DOX)
plasmid
CRISPR
(pCRISPR)
cells.
investigation
focused
whether
surface
modification
with
amine
groups
could
improve
cellular
uptake
transfection
efficiency.
In
addition,
also
engineered
cell-imprinted
substrate
mimic
environment
enhance
expression
edited
genes.
results
demonstrated
nanocarriers
successfully
co-delivered
DOX
pCRISPR,
indicating
their
potential
combination
therapy.
Specific
highlights
include
(1)
reliable
platform
multi-drug
based
)-MIL-125(Ti)/poly(aniline-
-para-phenylenediamine)/MnFe
O
4
structure;
(2)
hemocompatibility
analysis
revealed
less
than
1%
hemolysis,
pointing
biosafety;
(3)
enhanced
up
38.3%
in
A549
cells,
improving
transfection;
(4)
therapeutic
efficacy
by
promoting
a
physiologically
relevant
microenvironment.
Overall,
this
makes
significant
contributions
nanocomposite,
modification,
cell-mimetic
employ
strategies
augment
therapy
against
cancer.
Graphical
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 22, 2024
Abstract
Cancer
therapy
necessitates
the
development
of
novel
and
effective
treatment
modalities
to
combat
complexity
this
disease.
In
project,
we
propose
a
synergistic
approach
by
combining
chemo-photothermal
using
gold
nanorods
(AuNRs)
supported
on
thiol-functionalized
mesoporous
silica,
offering
promising
solution
for
enhanced
lung
cancer
therapy.
To
begin,
MCM-41
was
synthesized
surfactant-templated
sol–gel
method,
chosen
its
desirable
porous
structure,
excellent
biocompatibility,
non-toxic
properties.
Further,
achieved
through
simple
grafting
process,
enabling
subsequent
synthesis
AuNRs
(AuNR@S-MCM-41)
via
gold-thiol
interaction.
The
nanocomposite
then
loaded
with
anticancer
drug
doxorubicin
(DOX),
resulting
in
AuNR@S-MCM-41-DOX.
Remarkably,
exhibited
pH/NIR
dual-responsive
release
behaviors,
facilitating
targeted
delivery.
addition,
it
demonstrated
exceptional
biocompatibility
efficient
internalization
into
A549
cells.
Notably,
combined
photothermal-chemo
AuNR@S-MCM-41-DOX
superior
efficacy
killing
cells
compared
single
chemo-
or
photothermal
therapies.
This
study
showcases
potential
as
candidate
treatment.
innovative
integration
nanorods,
provides
comprehensive
therapeutic
improved
outcomes
Future
advancements
based
strategy
hold
promise
addressing
challenges
posed
transforming
patient
care.
Journal of Controlled Release,
Journal Year:
2022,
Volume and Issue:
351, P. 174 - 197
Published: Sept. 22, 2022
Nanoscale
materials
have
been
extensively
employed
for
diagnostic
and
therapeutic
purposes.
However,
the
developed
nanosystems
still
suffer
from
some
limitations,
namely
rapid
elimination
by
immune
system,
lack
of
targeting
to
specific
cells,
insufficient
biocompatibility.
Therefore,
novel
strategies
based
upon
a
biomimetic
approach
received
attention
improving
pharmacokinetics
safety
profile
nanosystems.
One
promising
strategy
is
application
coating
consisting
cell
membranes
derived
different
types
onto
nanoparticle
cores.
Stem
cells
investigated
develop
targeted
nanodevices
owing
their
excellent
intrinsic
tissue-specific
homing
features,
protecting
them
system
reach
sites
inflammation.
This
ability
conferred
surface
repertoire
stem
cell-associated
biomolecules.
Such
nanoscopical
offer
sustained
circulation
boosted
drug
accumulation
at
target
sites,
augmenting
efficacy
safety.
Additionally,
nanoparticles
with
acts
as
camouflage
mechanism
increase
time.
The
current
review
explores
particular
features
membrane
multifunctional
functionalization
agents
Biomedical
applications
engineered
membrane-coated
nanoparticles,
challenges
in
clinical
translation,
future
prospects
are
addressed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(2), P. 413 - 413
Published: Jan. 26, 2023
The
development
of
biomaterials
has
a
substantial
role
in
pharmaceutical
and
medical
strategies
for
the
enhancement
life
quality.
This
review
work
focused
on
versatile
based
nanocomposites
comprising
organic
polymers
class
layered
inorganic
nanoparticles,
aiming
drug
delivery
(oral,
transdermal,
ocular
delivery)
tissue
engineering
(skin
bone
therapies).
Layered
double
hydroxides
(LDHs)
are
2D
nanomaterials
that
can
intercalate
anionic
bioactive
species
between
layers.
layers
hold
metal
cations
confer
intrinsic
biological
activity
to
LDHs
as
well
biocompatibility.
intercalation
allows
formation
systems
with
elevated
loading
capacity
modified
release
profiles
promoted
by
ion
exchange
and/or
solubilization.
integration,
antigenicity,
stimulation
collagen
formation,
among
other
beneficial
characteristics
LDH,
have
been
observed
vivo
assays.
association
properties
biocompatible
LDH-drug
nanohybrids
produces
multifunctional
compatible
living
matter.
Such
stimuli-responsive,
show
appropriate
mechanical
properties,
be
prepared
creative
methods
allow
fine-tuning
release.
They
processed
end
form
films,
beads,
gels,
monoliths
etc.,
reach
orientated
therapeutic
applications.
Several
studies
attest
higher
performance
polymer/LDH-drug
nanocomposite
compared
hybrid
or
free
drug.
