Nanoscale self-assembly and water retention properties of silk fibroin–riboflavin hydrogel DOI

Aarti Kumari,

Goodwin Stephen P.,

Moumita Saharay

et al.

The Journal of Chemical Physics, Journal Year: 2025, Volume and Issue: 162(2)

Published: Jan. 8, 2025

Silk-fibroin hydrogels have gained considerable attention in recent years for their versatile biomedical applications. The physical properties of a complex hydrogel, comprising silk fibroin and riboflavin, surpass those the fibroin-hydrogel without additives. This study investigates fibroin–riboflavin (silk–RIB) hydrogel at atomistic level to uncover molecular structures chemical characteristics specific riboflavin molecules an aqueous medium. interplay between hydrophilic hydrophobic polymers facilitates formation solubilized fiber, which subsequently evolves into nano-scale over time. Eventually, interlinked RIB stacks form scaffold that not only accommodates aggregates but also encloses water pockets, preserving moisture enhancing thermal conductivity hydrogel. To explore retention role ions, two sets simulations semi-hydrated presence absence ions are conducted. significantly influences dynamics fibroin. Favorable interactions with impede unrestricted diffusion these larger molecules, potentially leading stable structure capable retaining prolonged duration. complete removal results further shrinkage anhydrous silk–RIB or xerogel (XG), yet its porosity structural integrity remain intact. These findings offer valuable insights behavior XG, paving way materials engineering environments develop devices customized functional properties.

Language: Английский

Polymer-Based Hydrogels Applied in Drug Delivery: An Overview DOI Creative Commons
Hoc Thang Nguyen,

Truong Bach Chien,

Đặng Xuân Cường

et al.

Gels, Journal Year: 2023, Volume and Issue: 9(7), P. 523 - 523

Published: June 27, 2023

Polymer-based hydrogels are hydrophilic polymer networks with crosslinks widely applied for drug delivery applications because of their ability to hold large amounts water and biological fluids control release based on unique physicochemical properties biocompatibility. Current trends in the development hydrogel systems involve drugs response specific triggers such as pH, temperature, or enzymes targeted reduce potential systemic toxicity. In addition, developing injectable formulations that easily used sustain during this extended time is a growing interest. Another emerging trend synthesis nano other functional substances improving loading efficacy. Following these trends, advanced possessing mechanically improved properties, controlled rates, biocompatibility focus field. More complex multi-drug combination therapies will be developed advancements. polymer-based gaining increasing attention personalized medicine tailored patient, example, combinations, target-specific delivery, improvement disease treatment effectiveness, healthcare cost reduction. Overall, application advancing rapidly, towards more efficient effective future.

Language: Английский

Citations

295
Novel Natural Polymer‐Based Hydrogel Patches with Janus Asymmetric‐Adhesion for Emergency Hemostasis and Wound Healing DOI
Lanfang Sun,

Junyi Zhou,

Jieying Lai

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(36)

Published: April 27, 2024

Abstract An asymmetrical wound dressing functions akin to human skin by serving as a protective barrier between and its immediate environment. However, significant challenges persist concerning the robust adhesion properties of hydrogels, particularly when applied in emergency hemostasis healing contexts. Herein, study has successfully synthesized hydrogel patches with Janus asymmetric‐adhesion, denoted HGO‐C, exclusively comprised natural polymers. This achievement is realized through assembly adhesive (HGO) non‐adhesive (CGC), thereby amalgamating their distinct functionalities. The component served physical shield safeguarding against contamination, while hydrogel, contacted surface, firmly adhered it, swiftly arresting bleeding facilitating healing. Cytocompatibility tests, hemolysis antibacterial assays, coagulation assays demonstrated excellent biocompatibility, antibacterial, hemostatic HGO‐C. Finally, vivo experiments, including liver hemorrhage assay assay, unequivocally showed rapid enhanced capabilities Consequently, these distinctive patches, derived from polymers characterized asymmetric properties, may have great potential for real‐life usage clinical patients.

Language: Английский

Citations

38
Biomedical applications of stimuli-responsive “smart” interpenetrating polymer network hydrogels DOI Creative Commons

Jiuping Wu,

Wu Xue,

Zhihe Yun

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100998 - 100998

Published: Feb. 10, 2024

In recent years, owing to the ongoing advancements in polymer materials, hydrogels have found increasing applications biomedical domain, notably realm of stimuli-responsive "smart" hydrogels. Nonetheless, conventional single-network frequently exhibit deficiencies, including low mechanical strength, limited biocompatibility, and extended response times. response, researchers addressed these challenges by introducing a second network create Interpenetrating Polymer Network (IPN) The strength material can be significantly improved due topological entanglement physical interactions within interpenetrating structure. Simultaneously, combining different structures enhances biocompatibility stimulus responsiveness gel, endowing it with unique properties such as cell adhesion, conductivity, hemostasis/antioxidation, color-changing capabilities. This article primarily aims elucidate stimulus-inducing factors IPN hydrogels, impact gels on behaviors their application range. Additionally, we also offer an in-depth exposition categorization, mechanisms, performance characteristics, related aspects. review furnishes comprehensive assessment outlook for advancement arena. We believe that, field increasingly demands novel materials featuring properties, robust heightened responsiveness, will hold substantial promise wide-ranging this domain.

Language: Английский

Citations

37
Engineering multifunctional dynamic hydrogel for biomedical and tissue regenerative applications DOI Creative Commons
Bohan Yin,

Monika Gosecka,

Mahdi Bodaghi

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150403 - 150403

Published: March 16, 2024

Hydrogels have emerged in various biomedical applications, including tissue engineering and medical devices, due to their ability imitate the natural extracellular matrix (ECM) of tissues. However, conventional static hydrogels lack dynamically respond changes surroundings withstand robust biophysical microenvironment trigger on-demand functionality such as drug release mechanical change. In contrast, multifunctional dynamic can adapt external stimuli drawn great attention recent studies. It is realized that integration nanomaterials into provides numerous functionalities for a variety applications cannot be achieved by hydrogels. This review article comprehensive overview advances designing fabricating applications. We describe different types based on breakable reversible covalent bonds well noncovalent interactions. These mechanisms are described detail useful reference crosslinking strategies strongly influence properties also discuss use potential benefits. further explores nanocomposite hydrogels, delivery, engineering, bioadhesives, wound healing, cancer treatment, mechanistic study, multiple-scale Finally, we challenges future perspectives field diverse technologies.

Language: Английский

Citations

34
Electrospinning/3D printing drug-loaded antibacterial polycaprolactone nanofiber/sodium alginate-gelatin hydrogel bilayer scaffold for skin wound repair DOI

Yongteng Song,

Qingxi Hu,

Suihong Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 275, P. 129705 - 129705

Published: Jan. 23, 2024

Language: Английский

Citations

32
Bioinspired Microstructured Janus Bioadhesive for the Prevention of Abdominal and Intrauterine Adhesions DOI
Yuancai Lv,

Fengying Cai,

Xingkai Zhao

et al.

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(21)

Published: Jan. 28, 2024

Abstract Abdominal and intrauterine adhesions are common postoperative problems that can cause serious complications. Current adhesives usually double sided suffer from poor wet adhesion, nondegradability, monofunctionality, which limits their application in preventing adhesions. Herein, a bioinspired microstructured Janus bioadhesive, named OD/GM@PG, with adhesive inner layer an antiadhesive outer is prepared by combining electrostatic spun materials. By using both capillary suction catechol‐based strategy, the strength interfacial toughness of bioadhesive reach 98 kPa 325 J m −2 , respectively, much higher than those commercial fibrin glues cyanoacrylate glues. The acts as physical barrier friction‐reducing effects. Additionally, demonstrates biodegradable, hemostatic, antioxidative, anti‐inflammatory, prohealing properties. In vivo results show asymmetric adhesion effect effectively abdominal Notably, tandem mass tags‐labeled quantitative proteomics analysis demonstrate expression inflammatory response‐associated proteins (S100A8, S100A9) associated adhesion; significantly downregulates this expression. Therefore, OD/GM@PG promising candidate for

Language: Английский

Citations

23
Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing DOI Creative Commons

Xuehao Tian,

Yuting Wen, Zhongxing Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

Citations

4
Biocompatible tissue-engineered scaffold polymers for 3D printing and its application for 4D printing DOI
Rezgar Hasanzadeh, Peyman Mihankhah, Taher Azdast

et al.

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 476, P. 146616 - 146616

Published: Oct. 13, 2023

Language: Английский

Citations

37
3D Bioprinting of Double‐Layer Conductive Skin for Wound Healing DOI
Yuhan Wang, Chen Gao,

Shengnan Cheng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Abstract Conductive hydrogels are highly attractive in 3D bioprinting of tissue engineered scaffolds for skin injury repair. However, their application is limited by mismatched electrical signal conduction mode and poor printability. Herein, the bioprinting‐assisted fabrication a double‐layer ionic conductive scaffold using newly designed biomimetic bioink (GHCM) reported, which composed gelatin methacrylate (GelMA), oxidized hyaluronic acid (OHA), carboxymethyl chitosan (CMCS), 2‐methacryloyloxyethyl phosphorylcholine (MPC) treatment full‐thickness defects. The combination rigid (GelMA) dynamic (OHA‐CMCS) polymer networks imparts GHCM excellent reversible thixotropy, enabling good printability, allowing creation skin‐like constructs with high shape fidelity cell activity convenient one‐step bioprinting. Moreover, incorporation zwitterionic MPC endows signaling pattern similar to that natural tissue. By integrating human foreskin fibroblasts (HFF‐1), umbilical vein endothelial cells (HUVECs), immortalized keratinocytes (HaCaTs), comprising an epidermal layer vascularized dermal created. In vivo experiments have demonstrated provide appropriate microenvironment cellular signaling, growth, migration, differentiation, ultimately accelerating re‐epithelialization, collagen deposition, vascularization wounds, may represent general versatile strategy precise engineering electroactive tissues regenerative medicine applications.

Language: Английский

Citations

1
Conductive Hydrogel‐Based Neural Interfaces: From Fabrication Methods, Properties, to Applications DOI Creative Commons
Xinyu Xue, Lu Han, Han Cai

et al.

Small Structures, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Conductive hydrogels provide a flexible platform technology that enables the development of personalized materials for various neuronal diagnostic and therapeutic applications, combining complementary properties conductive hydrogels. By ensuring conductivity through materials, largely compensate rigidity traditional inorganic making them suitable substitute. To adapt to different working environments, exhibit excellent properties, such as mechanical adhesion, biocompatibility, which further expand their applications. This review summarizes fabrication methods, applications in neural interfaces. Finally, prevailing challenges outlines future directions field interfaces are provided, emphasizing need interdisciplinary research address issues long‐term stability scalability production.

Language: Английский

Citations

1