Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136987 - 136987
Published: April 1, 2025
Language: Английский
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 440 - 440
Published: July 1, 2024
Cancer is a highly heterogeneous disease and remains global health challenge affecting millions of human lives worldwide. Despite advancements in conventional treatments like surgery, chemotherapy, immunotherapy, the rise multidrug resistance, tumor recurrence, their severe side effects complex nature microenvironment (TME) necessitates innovative therapeutic approaches. Recently, stimulus-responsive nanomedicines designed to target TME characteristics (e.g., pH alterations, redox conditions, enzyme secretion) have gained attention for potential enhance anticancer efficacy while minimizing adverse chemotherapeutics/bioactive compounds. Among various nanocarriers, hydrogels are intriguing due high-water content, adjustable mechanical characteristics, responsiveness external internal stimuli, making them promising candidates cancer therapy. These properties make an ideal nanocarrier controlled drug release within TME. This review comprehensively surveys latest area therapy, exploring stimuli-responsive mechanisms, including biological pH, redox), chemical enzymes, glucose), physical temperature, light), as well dual- or multi-stimuli responsiveness. Furthermore, this addresses current developments challenges treatment. Our aim provide readers with comprehensive understanding treatment, offering novel perspectives on development therapy other medical applications.
Language: Английский
Citations
11
Discover Materials, Journal Year: 2024, Volume and Issue: 4(1)
Published: Aug. 28, 2024
Nanocomposite hydrogels (NHs) have emerged as a groundbreaking tool in biomedical applications, offering remarkable versatility and efficacy. Integrating wide range of nanoparticles, including carbon-based, polymeric, ceramic, metallic nanomaterials, within hydrogel networks results nanocomposites with superior properties tailored functionalities. Recent research has highlighted their potential to address key challenges drug delivery, cancer therapy, tissue regeneration, biosensing, wound healing, outstanding biocompatibility bioavailability. Nanohydrogels demonstrate significant promise delivery systems biological sensors, providing sustained therapeutic activity at targeted sites. This reduces the frequency administration minimizes harmful side effects. In healthcare sector, they applications ranging from therapy aesthetic corrections are leading topic regeneration research. comprehensive review Biomedical Applications investigates latest advancements NHs, focusing on classification, unique properties, diverse applications. By identifying future prospects existing gaps, this aims highlight diagnostic nanocomposite technology, covering way for further advancement field.
Language: Английский
Citations
9
Polymers, Journal Year: 2024, Volume and Issue: 16(14), P. 2050 - 2050
Published: July 18, 2024
Significant developments have been achieved with the invention of hydrogels. They are effective in many fields such as wastewater treatment, food, agriculture, pharmaceutical applications, and drug delivery. Although hydrogels used successfully these areas, there is a need to make them better for future applications. Interpenetrating polymer networks (IPNs) can be created more adjustable suitable specific purpose. IPN formation an innovative approach polymeric systems. It brings two or together entanglements. The properties IPNs controlled by its chemistry, crosslinking density, morphology. Therefore, it necessary understand characterization methods order detect structure develop In recent studies, has determined via chemical, physical, mechanical Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, scanning electron microscopy (SEM), field emission (FESEM), differential calorimetry (DSC), dynamic analysis (DMA), X-ray diffraction (XRD), rheology methods. this paper, will explained, studies scrutinized, effectiveness confirm evaluated.
Language: Английский
Citations
6
RSC Advances, Journal Year: 2024, Volume and Issue: 14(20), P. 14425 - 14437
Published: Jan. 1, 2024
In this study, we present a method to fabricate pH-sensitive membranes using UV-initiated RAFT graft copolymerization of styrene and acrylic acid on PET track-etched for separation water–oil emulsions.
Language: Английский
Citations
4
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 524 - 540
Published: June 1, 2024
Pulpitis, an inflammatory disease of dental pulp tissues, ultimately results in the loss defense properties. Existing clinical modalities cannot effectively promote inflamed repair. Oxidative stress is a major obstacle inhibiting Due to their powerful antioxidative capacity, mesenchymal stem cell-derived small extracellular vesicles (MSC-sEVs) exhibit potential for treating oxidative stress-related disorders. However, whether MSC-sEVs shield tissues from damage largely unknown. Here, we showed that follicle sEVs (DFSC-sEVs) have and prohealing effects on rat LPS-induced pulpitis model by enhancing survival, proliferation odontogenesis H2O2-injured cells (DPSCs). Additionally, DFSC-sEVs restored oxidative/antioxidative balance DPSC mitochondria had comparable ameliorating mitochondrial dysfunction with mitochondrion-targeted antioxidant Mito-Tempo. To improve efficacy DFSC-sEVs, fabricated intelligent injectable hydrogel release combining sodium alginate (SA) ROS sensor RhB-AC. The newly formed SA-RhB efficiently encapsulates exhibits controlled HClO/ClO− concentration-dependent manner, providing synergistic effect DFSC-sEVs. These suggest DFSC-sEVs-loaded promising minimally invasive treatment tissue repair wound microenvironment.
Language: Английский
Citations
4
Macromolecular Rapid Communications, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 30, 2024
Semi-interpenetrating polymer networks (SIPNs) have garnered significant interest due to their potential applications in self-healing materials, drug delivery systems, electrolytes, functional membranes, smart gels and, toughing. SIPNs combine the characteristics of physical cross-linking with advantageous chemical properties, offering broad application prospects materials science and engineering. This perspective introduces history semi-interpenetrating diverse applications. Additionally, ongoing challenges associated traditional are discussed provide an outlook on future advancements novel SIPNs.
Language: Английский
Citations
4
Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 715 - 715
Published: Nov. 6, 2024
The current state of affairs in the field using polymer hydrogels for creation innovative systems signal and image processing, which computing is a special case, analyzed. Both these specific examples capable forming an alternative to existing semiconductor-based technology, but assuming preservation used algorithmic basis, non-trivial converters, nature requires transition fundamentally different algorithms data are considered. It shown that variability currently developed information processing based on use polymers, including hydrogels, leads need search complementary algorithms. Moreover, well-known thesis modern science allows realization functional materials with predetermined properties, at present stage, receives new sounding: it acceptable raise question creating built quasi-biological basis realizing or processing. Specific meet this considered, particular, promising protection UAV groups, as well coupling neural networks holograms solve various applied problems. These other case studies demonstrate importance interdisciplinary cooperation solving problems arising from further modernization systems.
Language: Английский
Citations
4
Materials Chemistry Frontiers, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
We designed the asymmetric cyanine amphiphile DPIIF, which exhibits reversible photochromism, pH responsiveness, and sol–gel transitions, offering potential applications in information security, anti-counterfeiting, biomedical studies.
Language: Английский
Citations
0
Journal of Materials Chemistry C, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Conductive hydrogels derived from biopolymers are rapidly gaining prominence as a key research direction in the field of flexible wearable sensors.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 304, P. 140961 - 140961
Published: Feb. 12, 2025
Language: Английский
Citations
0