Smart Materials in Medicine, Journal Year: 2024, Volume and Issue: 5(3), P. 425 - 446
Published: Sept. 1, 2024
Language: Английский
Exploration, Journal Year: 2023, Volume and Issue: 4(2)
Published: Oct. 17, 2023
Abstract The emergence of drug‐resistant bacteria poses a significant threat to people's lives and health as bacterial infections continue persist. Currently, antibiotic therapy remains the primary approach for tackling infections. However, escalating rates drug resistance coupled with lag in development novel drugs have led diminishing effectiveness conventional treatments. Therefore, nonantibiotic‐dependent therapeutic strategies has become imperative impede rise resistance. chemodynamic (CDT) opened up new possibility due CDT can convert H 2 O into •OH via Fenton/Fenton‐like reaction treatment. efficacy is limited by variety practical factors. To overcome this limitation, sterilization efficiency be enhanced introducing therapeutics inherent antimicrobial capability. In addition, researchers explored CDT‐based combined therapies augment its effects mitigate potential toxic side toward normal tissues. This review examines research progress field, explores various enhance presents synergistic combination other modalities. And last, current challenges faced future directions are discussed.
Language: Английский
Citations
55
Small Methods, Journal Year: 2024, Volume and Issue: 8(8)
Published: Jan. 9, 2024
Abstract Oxygen (O 2 ), nitric oxide (NO), carbon monoxide (CO), hydrogen sulfide (H S), and ) with direct effects, dioxide (CO complementary effects on the condition of various diseases are known as therapeutic gases. The targeted delivery in situ generation these gases controllable release at site disease has attracted attention to avoid risk gas poisoning improve their performance treating such cancer therapy, cardiovascular bone tissue engineering, wound healing. Stimuli‐responsive gas‐generating sources systems based biomaterials that enable on‐demand promising approaches for precise therapy. This work highlights current advances design development new generate deliver behavior. delivered biomedical applications is then discussed.
Language: Английский
Citations
19
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: March 16, 2024
Abstract Reactive oxygen species (ROS) has emerged as potent therapeutic agents for biofilm-associated bacterial infections. Chemodynamic therapy (CDT), involving the generation of high-energy ROS, displays great potential in However, challenges such insufficient hydrogen peroxide (H 2 O ) and over-expressed glutathione (GSH) levels within microenvironment biofilms severely limit antibacterial efficacy CDT. Herein, we have developed a multifunctional nanoplatform (CuS@CaO @Dex) by integrating copper sulfide (CuS) calcium (CaO into dextran (Dex)-coated nanoparticles. This innovative platform enhanced ROS highly efficient biofilm elimination simultaneously supplying H depleting GSH. The Dex-coating facilitated penetrability CuS@CaO @Dex biofilms, while CaO generated substantial amount acidic microenvironment. CuS, through Fenton-like reaction, catalyzed conversion self-supplied hydroxyl radicals (•OH) consumed overexpressed Additionally, incorporation near-infrared II (NIR II) laser irradiation photothermal properties improving catalytic efficiency reaction effects. In vivo experiments demonstrated that exhibited remarkable antibiofilm efficacy, exceptional wound healing capabilities, notable biosafety. summary, Dex-coated proposed this study, with its self-sterilization capability holds significant future biomedical applications.
Language: Английский
Citations
18
Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136228 - 136228
Published: Jan. 1, 2025
Language: Английский
Citations
2
Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)
Published: May 4, 2023
Treatment of methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections in implant placement surgery is limited by the lack antimicrobial activity titanium (Ti) implants. There a need to explore more effective approaches for treatment MRSA infections.Herein, an interfacial functionalization strategy proposed integration mesoporous polydopamine nanoparticles (PDA), nitric oxide (NO) release donor sodium nitroprusside (SNP) and osteogenic growth peptide (OGP) onto Ti implants, denoted as Ti-PDA@SNP-OGP. The physical chemical properties Ti-PDA@SNP-OGP were assessed scanning electron microscopy, X-ray photoelectron spectroscope, water contact angle, photothermal property NO behavior. synergistic antibacterial effect elimination biofilms evaluated 2',7'-dichlorofluorescein diacetate probe, 1-N-phenylnaphthylamine assay, adenosine triphosphate intensity, o-nitrophenyl-β-D-galactopyranoside hydrolysis activity, bicinchoninic acid leakage. Fluorescence staining, assays alkaline phosphatase collagen secretion extracellular matrix mineralization, quantitative real‑time reverse transcription‑polymerase chain reaction, enzyme-linked immunosorbent assay (ELISA) used evaluate inflammatory response ability bone marrow stromal cells (MSCs), RAW264.7 their co-culture system. Giemsa ELISA, micro-CT, hematoxylin eosin, Masson's trichrome immunohistochemistry staining eradication biofilms, inhibition response, promotion osseointegration vivo.Ti-PDA@SNP-OGP displayed NO-dependent against following near-infrared light irradiation, effectively eliminated formed inducing reactive oxygen species (ROS)-mediated oxidative stress, destroying bacterial membrane integrity causing leakage intracellular components (P < 0.01). In vitro experiments revealed that not only facilitated differentiation MSCs, but also promoted polarization pro-inflammatory M1 macrophages anti-inflammatory M2-phenotype 0.05 or P favorable osteo-immune microenvironment further osteogenesis MSCs anti-inflammation via multiple paracrine signaling pathways vivo evaluation confirmed aforementioned results induced ameliorative MRSA-infected femoral defect implantation model 0.01).These findings suggest promising multi-functional material high-efficient replacement surgeries.
Language: Английский
Citations
35
ACS Nano, Journal Year: 2023, Volume and Issue: 17(15), P. 14840 - 14851
Published: July 26, 2023
The rapid development of sonodynamic therapy (SDT) provides a promising strategy for treating deep-seated multidrug-resistant (MDR) bacterial infection. However, the extreme scarcity biologically functional and highly efficient sonosensitizers severely limits further clinical practice SDT. Herein, lattice-strain-rich Ti3C2 (LS-Ti3C2) with greatly improved sonosensitizing effect is one-step synthesized using meso-tetra(4-carboxyphenyl)porphine (TCPP) by solvothermal method realizing extraordinary intervention TCPP causes all Ti–O chemical bonds most Ti–F on surface layer to break down. amino groups are then recombined these exposed Ti atoms perturb order atoms, resulting in displacement final lattice structural distortion Ti3C2. inherent strain narrows band gap Ti3C2, which mainly facilitates electron–hole pair separation electron transfer under ultrasound irradiation, thereby US-mediated reactive oxygen species (ROS) production subsequent robust bactericidal capability (99.77 ± 0.16%) against methicillin-resistant Staphylococcus aureus (MRSA). Overall, this research offers perspective into Ti-familial toward SDT practice.
Language: Английский
Citations
23
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)
Published: Feb. 26, 2024
Abstract Drug‐resistant bacterial infection of cutaneous wounds causes great harm to the human body. These infections are characterized by a microenvironment with recalcitrant infections, persistent oxidative stress, imbalance immune regulation, and suboptimal angiogenesis. Treatment strategies available date incapable handling healing dynamics infected wounds. A Schiff base borate ester cross‐linked hydrogel, based on phenylboronic acid‐grafted chitosan (CS‐PBA), dibenzaldehyde‐grafted poly(ethylene glycol), tannic acid (TA), is fabricated in present study. Customized acid‐modified zinc oxide nanoparticles (ZnO) embedded hydrogel prior gelation. The CPP@ZnO‐P‐TA effectively eliminates methicillin‐resistant Staphylococcus aureus (MRSA) due pH‐responsive release Zn 2+ TA. Killing achieved via membrane damage, adenosine triphosphate reduction, leakage intracellular components, hydrolysis o ‐nitrophenyl‐β‐ d ‐galactopyranoside. capable scavenging reactive oxygen nitrogen species, alleviating stimulating M2 polarization macrophages. released TA also induce neovascularization PI3K/Akt pathway. improves tissue regeneration vivo inflammatory responses, angiogenesis, facilitating collagen deposition. findings suggest that this versatile possesses therapeutic potential for treatment MRSA‐infected
Language: Английский
Citations
16
Small, Journal Year: 2024, Volume and Issue: 20(29)
Published: Feb. 20, 2024
As the global population ages, bone diseases have become increasingly prevalent in clinical settings. These conditions often involve detrimental factors such as infection, inflammation, and oxidative stress that disrupt homeostasis. Addressing these disorders requires exogenous strategies to regulate osteogenic microenvironment (OME). The regulation of OME can be divided into four processes: induction, modulation, protection, support, each serving a specific purpose. To this end, metal-organic frameworks (MOFs) are an emerging focus nanomedicine, which show tremendous potential due their superior delivery capability. MOFs play numerous roles metal ion donors, drug carriers, nanozymes, photosensitizers, been extensively explored recent studies. This review presents comprehensive introduction by MOF-based nanomaterials. By discussing various functional MOF composites, work aims inspire guide creation sophisticated efficient nanomaterials for disease management.
Language: Английский
Citations
12
Bioactive Materials, Journal Year: 2024, Volume and Issue: 36, P. 287 - 300
Published: March 8, 2024
The rheumatoid arthritis (RA) microenvironment is often followed by a vicious circle of high inflammation, endogenous gas levels imbalance, and poor treatment. To break the circle, we develop dual-gas-mediated injectable hydrogel for modulating immune RA simultaneously releasing therapeutic drugs. (DNRS gel) could be broken down on-demand consuming excessive nitric oxide (NO) hydrogen sulfide (H
Language: Английский
Citations
10
Military Medical Research, Journal Year: 2024, Volume and Issue: 11(1)
Published: April 18, 2024
Abstract Chronic, non-healing wounds represent a significant challenge for healthcare systems worldwide, often requiring human and financial resources. Chronic arise from the complex interplay of underlying comorbidities, such as diabetes or vascular diseases, lifestyle factors, genetic risk profiles which may predispose extremities to local ischemia. Injuries are further exacerbated by bacterial colonization formation biofilms. Infection, consequently, perpetuates chronic inflammatory microenvironment, preventing progression completion normal wound healing. The current standard care (SOC) involves surgical debridement along with localized irrigation, requires inpatient under general anesthesia. This could be followed by, if necessary, defect coverage via reconstructive ladder utilizing skin graft, local, free flap techniques once conditions stabilized adequate blood supply is restored. To promote physiological healing, variety approaches have been subjected translational research. Beyond conventional healing drugs devices that currently supplement treatments, cellular immunotherapies emerged promising therapeutics can behave tailored therapies cell- molecule-specific properties. However, in contrast clinical omnipresence disorders, there remains shortage studies condensing body evidence on wounds. review provides comprehensive exploration therapies, experimental approaches, studies, offering insights into their efficacy limitations. Ultimately, we hope this line research serve an evidence-based foundation guide optimize patient long-term.
Language: Английский
Citations
10