An Immunomodulatory Hydrogel by Hyperthermia‐Assisted Self‐Cascade Glucose Depletion and ROS Scavenging for Diabetic Foot Ulcer Wound Therapeutics

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(48)

Published: Oct. 7, 2023

Abstract Current therapeutic protocols for diabetic foot ulcers (DFUs), a severe and rapidly growing chronic complication in patients, remain nonspecific. Hyperglycemia‐caused inflammation excessive reactive oxygen species (ROS) are common obstacles encountered DFU wound healing, often leading to impaired recovery. These two effects reinforce each other, forming an endless loop. However, adequate inclusive methods still lacking target these aspects break the vicious cycle. This study proposes novel approach treating wounds, utilizing immunomodulatory hydrogel achieve self‐cascade glucose depletion ROS scavenging regulate microenvironment. Specifically, AuPt@melanin‐incorporated (GHM3) dressing is developed facilitate efficient hyperthermia‐enhanced local scavenging. Mechanistically, vitro/vivo experiments RNA sequencing analysis demonstrate that GHM3 disrupts ROS‐inflammation cascade cycle downregulates ratio of M1/M2 macrophages, consequently improving outcomes dorsal skin wounds rats. In conclusion, this proposed offers facile, safe, highly treatment modality DFUs.

Language: Английский

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Recent developments in natural biopolymer based drug delivery systems

RSC Advances, Journal Year: 2023, Volume and Issue: 13(33), P. 23087 - 23121

Published: Jan. 1, 2023

Our findings revealed that the composition of constituents, reaction conditions, and synthetic processes all influence characteristics therefore applications resulting biopolymer composites.

Language: Английский

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A Hybrid Hydrogel with Intrinsic Immunomodulatory Functionality for Treating Multidrug-Resistant Pseudomonas aeruginosa Infected Diabetic Foot Ulcers

ACS Materials Letters, Journal Year: 2024, Volume and Issue: 6(7), P. 2533 - 2547

Published: May 24, 2024

Contemporary options for multidrug-resistant bacteria infected diabetic foot ulcers (IDFUs) are predominantly nonspecific. These IDFU injuries often display prolonged inflammation and delayed tissue repair, mainly attributed to an overabundance of M1 macrophages in the hostile microenvironment. Although immunomodulatory hydrogels show promise IDFU-focused care, a targeted, safe transition from M2 using simplified techniques remains significant obstacle. Here, we introduce hybrid hydrogel (GGG) with inherent capabilities IDFUs. GGG is composed interpenetrating polymer networks featuring gallium-induced self-assembling glycyrrhizic acid photo-cross-linked gelatin methacryloyl matrix. Importantly, effectively decreases ratio conditions drug-resistant by disrupting iron metabolism scavenging reactive oxygen species, which contributes enhanced treatment results wounds. To sum up, strategy present provides straightforward, safe, highly effective therapeutic avenue managing

Language: Английский

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Natural biomarocmolecule-based antimicrobial hydrogel for rapid wound healing: A review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 244, P. 125454 - 125454

Published: June 16, 2023

Language: Английский

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Biomimetic peptide dynamic hydrogel inspired by humanized defensin nanonets as the wound-healing gel coating

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 470, P. 144266 - 144266

Published: June 20, 2023

Clinical treatment of chronic wounds, particularly those prone to relapse, has been hampered by the regeneration, infection complications, and malignant transformation disordered tissue adhesions. At surface intestinal endothelial, human defensins self-assemble into higher-order nanonets that defend host cells, fight inflammation promote wound healing. Inspired this antimicrobial nanostructured network, we herein attempted construct an nanonet with hemostatic function integrated as dressing. Aiding molecular docking dynamics analysis, designed a nanogel called ACFP, which was constructed spontaneously assembling two RADA16-based hydrogelators one θ-defensin-derived peptide motif. As expected, ACFP possesses properties derived from structure defensin, well ability prevent bleeding effectively injectable biocompatible hydrogel, successfully treated epidermal wounds associated multiple bacterial infections, promoted healing complicated intraperitoneal involving cecum adjacent abdominal walls while preventing adhesion. In addition providing comprehensive therapeutic approach tremendous clinical potential for therapy, may encourage development biomimetic hydrogels functions against wide range diseases.

Language: Английский

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Intelligent biobased hydrogels for diabetic wound healing: A review

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

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3D printing MOF nanozyme hydrogel with dual enzymatic activities and visualized glucose monitoring for diabetic wound healing

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 471, P. 144649 - 144649

Published: July 13, 2023

Language: Английский

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Polysaccharide-based hydrogel promotes skin wound repair and research progress on its repair mechanism

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 248, P. 125949 - 125949

Published: July 24, 2023

Language: Английский

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A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064

Published: March 15, 2024

Language: Английский

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A hyaluronic acid hydrogel as a mild photothermal antibacterial, antioxidant, and nitric oxide release platform for diabetic wound healing

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 543 - 555

Published: May 11, 2024

Language: Английский

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