Intelligent biobased hydrogels for diabetic wound healing: A review

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 484, P. 149493 - 149493

Published: Feb. 10, 2024

Language: Английский

---

Innovations in hydrogel-based manufacturing: A comprehensive review of direct ink writing technique for biomedical applications

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 324, P. 103095 - 103095

Published: Jan. 28, 2024

Direct ink writing (DIW) stands as a pioneering additive manufacturing technique that holds transformative potential in the field of hydrogel fabrication. This innovative approach allows for precise deposition inks layer by layer, creating complex three-dimensional structures with tailored shapes, sizes, and functionalities. By harnessing versatility hydrogels, DIW opens up possibilities applications spanning from tissue engineering to soft robotics wearable devices. comprehensive review investigates applied hydrogels its multifaceted applications. The paper introduces diverse range printing techniques while providing thorough exploration hydrogel-based printing. investigation aims explain progress made, challenges faced, trajectories lie ahead manufacturing. fundamental principles underlying are carefully examined, specifically focusing on rheological attributes parameters, prompting survey wide variety materials. These encompass both natural synthetic variations, all which can be effectively harnessed this purpose. Furthermore, explores latest biomedical areas, primary focus engineering, wound dressing, drug delivery systems. document not only consolidates existing state within context but also charts avenues further research breakthroughs.

Language: Английский

---

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 6, 2024

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients the healthcare system. Conventional therapies, such as corticosteroids nonsteroidal anti-inflammatory drugs, are limited in efficacy associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise addressing these challenges. NZ-based possess unique therapeutic abilities by combining benefits of redox nanomaterials enzymatic activity water-retaining capacity hydrogels. The multifaceted effects include scavenging reactive oxygen species other inflammatory mediators modulating immune responses toward pro-regenerative environment enhancing regenerative potential triggering cell migration differentiation. This review highlights current state art NZ-engineered (NZ@hydrogels) for regeneration applications. It also discusses underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, challenges future directions this ground, particularly clinical translation, addressed. insights provided aid design engineering novel hydrogels, offering new possibilities targeted personalized skin-care therapies.

Language: Английский

---

MOFs and MOF‐Based Composites as Next‐Generation Materials for Wound Healing and Dressings

Small, Journal Year: 2024, Volume and Issue: 20(30)

Published: March 7, 2024

Abstract In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of next‐generation dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, potential combination therapies make them suitable complex care challenges. MOF‐based composites promote cell proliferation, angiogenesis, matrix synthesis, acting as carriers bioactive molecules promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal skin cancer infections. Herein, critical analysis the current state research on MOFs dressings is provided, offering valuable insights into applications, challenges, future directions this field. This literature review targeted multifunctionality nature wound‐disease therapy from different aspects discussed most advancements made context, reader will find how contributed field yield more effective, functional, they lead next generation biomaterials

Language: Английский

---

A nano-composite hyaluronic acid-based hydrogel efficiently antibacterial and scavenges ROS for promoting infected diabetic wound healing

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 334, P. 122064 - 122064

Published: March 15, 2024

Language: Английский

---

Recent progress of MOF-based antibacterial hydrogels

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150641 - 150641

Published: March 26, 2024

Language: Английский

---

Recent Progress and Prospect of Metal–Organic Framework-Based Nanozymes in Biomedical Application

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(3), P. 244 - 244

Published: Jan. 23, 2024

A nanozyme is a nanoscale material having enzyme-like properties. It exhibits several superior properties, including low preparation cost, robust catalytic activity, and long-term storage at ambient temperatures. Moreover, high stability enables repetitive use in multiple reactions. Hence, it considered potential replacement for natural enzymes. Enormous research interest nanozymes the past two decades has made imperative to look better enzyme-mimicking materials biomedical applications. Given this, on metal–organic frameworks (MOFs) as gained momentum. MOFs are advanced hybrid of inorganic metal ions organic ligands. Their distinct composition, adaptable pore size, structural diversity, ease tunability physicochemical properties enable mimic activities act promising candidates. This review aims discuss recent advances development MOF-based (MOF-NZs) highlight their applications field biomedicine. Firstly, different enzyme-mimetic exhibited by discussed, insights given into various strategies achieve them. Modification functionalization deliberated obtain MOF-NZs with enhanced activity. Subsequently, biosensing therapeutics domain discussed. Finally, concluded giving challenges encountered possible directions overcome them future. With this review, we aim encourage consolidated efforts across enzyme engineering, nanotechnology, science, biomedicine disciplines inspire exciting innovations emerging yet field.

Language: Английский

---

Recent advances in smart hydrogels derived from polysaccharides and their applications for wound dressing and healing

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123134 - 123134

Published: Jan. 1, 2025

Language: Английский

---

3D-Printed MOF Monoliths: Fabrication Strategies and Environmental Applications

Nano-Micro Letters, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 15, 2024

Metal-organic frameworks (MOFs) have been extensively considered as one of the most promising types porous and crystalline organic-inorganic materials, thanks to their large specific surface area, high porosity, tailorable structures compositions, diverse functionalities, well-controlled pore/size distribution. However, developed MOFs are in powder forms, which still some technical challenges, including abrasion, dustiness, low packing densities, clogging, mass/heat transfer limitation, environmental pollution, mechanical instability during process, that restrict applicability industrial applications. Therefore, recent years, attention has focused on techniques convert MOF powders into macroscopic materials like beads, membranes, monoliths, gel/sponges, nanofibers overcome these challenges.Three-dimensional (3D) printing technology achieved much interest because it can produce many high-resolution with complex shapes geometries from digital models. this review summarizes combination different 3D strategies MOF-based for fabricating 3D-printed monoliths applications, emphasizing water treatment gas adsorption/separation Herein, various fabrication such direct ink writing, seed-assisted in-situ growth, coordination replication solid precursors, matrix incorporation, selective laser sintering, light processing, described relevant examples. Finally, future directions challenges also presented better plan trajectories shaping improved control over structure, composition, textural properties monoliths.

Language: Английский

---

Kill Two Birds with One Stone: Dual‐Metal MOF‐Nanozyme‐Decorated Hydrogels with ROS‐Scavenging, Oxygen‐Generating, and Antibacterial Abilities for Accelerating Infected Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 6, 2024

Abstract Diabetic wounds tend to develop into nonhealing associated with the complex inflammatory microenvironment of uncontrollable bacterial infection, reactive oxygen species (ROS) accumulation, and chronic hypoxia. Damaged blood vessels hinder metabolic circulation, aggravating hypoxia, ROS accumulation further exacerbating diabetic wound microenvironment. However, existing treatments a single functionality have difficulty healing complicated wounds. Therefore, developing an integrative strategy improve hostility is urgently needed. Herein, multifunctional genipin (GP)‐crosslinked chitosan (CS)‐based hydrogels decorated biomimetic metal–organic framework (MOF)‐nanozymes natural antibacterial agent chlorogenic acid (CGA), which named MOF/CGA@GP‐CS (MCGC), are prepared. With catalase (CAT)‐like activity, these dual‐metal MOF‐nanozymes promising bioreactors for simultaneously alleviating hypoxia by converting elevated endogenous H 2 O dissolved in In addition, other component polyphenolic CGA acts as mild agent, efficiently inhibiting infection avoiding antibiotic resistance. Impressively, MCGC accelerate infected eliminating oxidative stress, increasing oxygenation, reversing vivo. this work, effective based on hydrogel dressings successfully developed applied management.

Language: Английский

---