A chemo/chemodynamic nanoparticle based on hyaluronic acid induces ferroptosis and apoptosis for triple-negative breast cancer therapy

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 329, P. 121795 - 121795

Published: Jan. 9, 2024

Language: Английский

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Recent Advances in Fluorescent Probes for Cancer Biomarker Detection

Molecules, Journal Year: 2024, Volume and Issue: 29(5), P. 1168 - 1168

Published: March 6, 2024

Many important biological species have been identified as cancer biomarkers and are gradually becoming reliable targets for early diagnosis late therapeutic evaluation of cancer. However, accurate quantitative detection remains challenging due to the complexity systems diversity development. Fluorescent probes extensively utilized identifying substances their notable benefits being non-invasive, quickly responsive, highly sensitive selective, allowing real-time visualization, easily modifiable. This review critiques fluorescent used detecting imaging over last five years. Focuses made on design strategies small-molecule nano-sized probes, construction methods fluorescence sensing platforms, further applications in multiple biomarkers, including enzymes, reactive oxygen species, sulfur microenvironments. aims guide development excellent diagnostic promote broad application analysis diagnosis.

Language: Английский

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Metal-phenolic nanocatalyst rewires metabolic vulnerability for catalytically amplified ferroptosis

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 485, P. 150126 - 150126

Published: March 2, 2024

Language: Английский

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Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Ferroptosis, an iron-dependent form of regulatory cell death, has garnered significant interest as a therapeutic target in cancer treatment due to its distinct characteristics, including lipid peroxide generation and redox imbalance. However, clinical application oncology is currently limited by issues such suboptimal efficacy potential off-target effects. The advent nanotechnology provided new way for overcoming these challenges through the development activatable magnetic nanoparticles (MNPs). These innovative MNPs are designed improve specificity ferroptosis induction. This Review delves into chemical biological principles guiding design ferroptosis-based therapies imaging-guided therapies. It discusses mechanisms attributes ferroptosis, composition MNPs, their mechanism action inducers, integration with advanced imaging techniques monitoring. Additionally, we examine convergence other strategies, chemodynamic therapy, photothermal photodynamic sonodynamic immunotherapy, within context nanomedicine strategies utilizing MNPs. highlights multifunctional surpass limitations conventional treatments, envisioning future drug-resistance-free, precision diagnostics treating recalcitrant cancers.

Language: Английский

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Construction of ICT-based fluorescence probes for the imaging of biothios

Microchemical Journal, Journal Year: 2025, Volume and Issue: 210, P. 112968 - 112968

Published: Feb. 4, 2025

Language: Английский

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An ICT-switched fluorescent probe for visualizing lipid and HClO in lipid droplets during ferroptosis

Chemical Communications, Journal Year: 2023, Volume and Issue: 60(7), P. 835 - 838

Published: Dec. 7, 2023

An ICT-switched fluorescent probe has been developed for the visualization of lipid accumulation and hypochlorous acid in droplets during ferroptosis.

Language: Английский

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Multifunctional Mitochondria-Targeting Near-Infrared Fluorescent Probe for Viscosity, ONOO^–, Mitophagy, and Bioimaging

ACS Biomaterials Science & Engineering, Journal Year: 2023, Volume and Issue: 9(6), P. 3581 - 3589

Published: May 30, 2023

Irregularities in mitochondrial viscosity and peroxynitrite (ONOO–) concentration can lead to dysfunction. It is still a great challenge develop near-infrared (NIR) fluorescent probes simultaneously detect viscosity, endogenous ONOO–, mitophagy. Herein, multifunctional mitochondria-targeting NIR probe P-1 was first synthesized for detecting used quinoline cations as targeting moiety, arylboronate an ONOO– responsive group, detected the change of by twisted internal charge transfer (TICT) mechanism. The has excellent response during inflammation lipopolysaccharides (LPSs) mitophagy induced starvation at 670 nm. changes nystatin zebrafish showed that able microviscosity vivo. also good sensitivity with detection limit 6.2 nM successfully applied zebrafish. Moreover, ability distinguish between cancer cells normal cells. All these features make promising candidate -associated physiological pathological processes.

Language: Английский

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ONOO^– Activatable Fluorescent Sulfur Dioxide Donor for a More Accurate Assessment of Cell Ferroptosis

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(5), P. 2041 - 2051

Published: Jan. 25, 2024

Ferroptosis is critical in the treatment of tumor therapies. Thus, monitoring reactive oxygen species (ROS) great significance for accurate assessment ferroptosis without any interference. However, current probes ROS during suffer from a drawback that consume detection, which inhibits process and thus affects accuracy effectiveness ferroptosis. Herein, new fluorescent donor probe, TFMU-SO2D, with combination moiety SO2 designed synthesized by introducing aryl boronate moieties could give it ability to effectively recognize ONOO–. The released excess glutathione regulate oxidative stress elevating levels, would offset depletion TFMU-SO2D ensure process. experimental results demonstrated possessed satisfactory performance ONOO– as well simultaneously releasing stimulated monensin erastin RSL3. Additionally, capability synergized inhibit viability cancer cells was CCK8 assay, may be due fact can potentiate cell death increasing level. Overall, these combined indicated possesses excellent precisely monitor interference, significant accurately accessing ferroptosis, treatment, drug development.

Language: Английский

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Reversible Dual Fluorescence-Lifetime Imaging of Mitochondrial GSH and Microviscosity: Real-Time Evaluation of Ferroptosis Status

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(11), P. 4570 - 4579

Published: March 5, 2024

Ferroptosis, as a new form of regulated cell death, is implicated in various physiological and pathological processes. Developing single probe for an independent analysis multiple analytes related to ferroptosis can provide more accurate information simplify the detection procedures, but it faces great challenges. In this work, we develop fluorescent simultaneous GSH through ratiometric fluorescence response microviscosity via lifetime model. Based on reversible Michael addition reaction between unsaturated C═C bond, responds reversibly with variation fast time (t1/2 = 4.7 s). At same time, sensitive environmental viscosity by changing its lifetimes. The was applied monitor drug-induced process both classical Xc–/GSH/GPX4- DHODH-mediated defense mechanisms. We hope that will useful molecular tool real-time live-cell imaging dynamics, which benefit unveiling

Language: Английский

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A novel coumarin-linked tetraphenylethene fluorescent probe for simultaneous sensing of ATP and GSH

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135772 - 135772

Published: April 7, 2024

Language: Английский

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