Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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Advances in electroactive biomaterials: Through the lens of electrical stimulation promoting bone regeneration strategy

Journal of Orthopaedic Translation, Journal Year: 2024, Volume and Issue: 47, P. 191 - 206

Published: June 27, 2024

The regenerative capacity of bone is indispensable for growth, given that accidental injury almost inevitable. Bone relevant the aging population globally and repair large defects after osteotomy (e.g., following removal malignant tumours). Among many therapeutic modalities proposed to regeneration, electrical stimulation has attracted significant attention owing its economic convenience exceptional curative effects, various electroactive biomaterials have emerged. This review summarizes current knowledge progress regarding strategies improving repair. Such range from traditional methods delivering via electroconductive materials using external power sources self-powered biomaterials, such as piezoelectric nanogenerators. Electrical osteogenesis are related piezoelectricity. examines cell behaviour potential mechanisms electrostimulation in healing, aiming provide new insights regeneration biomaterials. roles rehabilitating microenvironment facilitate addressing whereby cues mediate regeneration. Interactions between osteogenesis-related cells summarized, leading proposals use stimulation-based therapies accelerate healing.

Language: Английский

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Renewable biomass-based aerogels: from structural design to functional regulation

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(14), P. 7489 - 7530

Published: Jan. 1, 2024

Global population growth and industrialization have exacerbated the nonrenewable energy crises environmental issues, thereby stimulating an enormous demand for producing environmentally friendly materials. Typically, biomass-based aerogels (BAs), which are mainly composed of biomass materials, show great application prospects in various fields because their exceptional properties such as biocompatibility, degradability, renewability. To improve performance BAs to meet usage requirements different scenarios, a large number innovative works past few decades emphasized importance micro-structural design regulating macroscopic functions. Inspired by ubiquitous random or regularly arranged structures materials nature ranging from micro meso macro scales, constructing microstructures often corresponds completely functions even with similar biomolecular compositions. This review focuses on preparation process, concepts, regulation methods, synergistic combination chemical compositions porous perspective gel skeleton pore structure. It not only comprehensively introduces effect physical BAs, but also analyzes potential applications corresponding thermal management, water treatment, atmospheric harvesting, CO

Language: Английский

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Recent Progress in Biomedical Scaffold Fabricated via Electrospinning: Design, Fabrication and Tissue Engineering Application

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Electrospinning is a significant manufacturing strategy to create micro/nanofiber platforms that can be considered biomedical scaffold for tissue engineering repair and regeneration. In recent years researchers have continuously broadened the equipment design materials development of electrospinning nanofiber (ENPs), which evolved from single‐needle multi‐needle creating 3D ENPs, diversify their application including drugs/cell/growth factors release, anti‐bacterial anti‐inflammatory, hemostasis, wound healing, Herein, multifunctional ENPs with bioactive polymer fabricated via in terms novel material design, construction various structures, requirements different regeneration are reviewed. Furthermore, this review delves into advancements facilitated by highlighting effectiveness versatility across types such as bone, cartilage, tendons, cardiac tissue, nerves. The discussion comprehensively addresses ongoing challenges selection, biodegradation mechanisms, bioactivation strategies, techniques specific applications. Moreover, outlines potential future research avenues aimed at enhancing ENPs‐based approaches engineering. This in‐depth analysis aims provide nuanced insights technical recommendations propel field forward

Language: Английский

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Neuroregulation during Bone Formation and Regeneration: Mechanisms and Strategies

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The skeleton is highly innervated by numerous nerve fibers. These fibers, in addition to transmitting information within the bone and mediating sensations, play a crucial role regulating tissue formation regeneration. Traditional engineering (BTE) often fails achieve satisfactory outcomes when dealing with large-scale defects, which frequently related lack of effective reconstruction neurovascular network. In recent years, increasing research has revealed critical nerves metabolism. Nerve fibers regulate cells through neurotransmitters, neuropeptides, peripheral glial cells. Furthermore, also coordinate vascular immune systems jointly construct microenvironment favorable for As signaling driver formation, neuroregulation spans entire process physiological activities from embryonic postmaturity remodeling repair. However, there currently comprehensive summaries these regulatory mechanisms. Therefore, this review sketches out function during Then, we elaborate on mechanisms coupling neuromodulation immunity. Finally, discuss several novel strategies neuro-bone (NBTE) based bone, focusing coordinated regeneration tissue.

Language: Английский

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Chitosan-based biomaterials for bone tissue engineering

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140923 - 140923

Published: Feb. 1, 2025

Language: Английский

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Bionic Bilayer Scaffold for Synchronous Hyperthermia Therapy of Orthotopic Osteosarcoma and Osteochondral Regeneration

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(7), P. 8538 - 8553

Published: Feb. 12, 2024

Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment. Herein, a bionic bilayer constituting croconaine dye-polyethylene glycol@sodium alginate hydrogel poly(l-lactide)/hydroxyapatite polymer matrix is fabricated simultaneously achieve highly efficient killing of accelerated osteochondral regeneration. First, biomimetic structure along with adequate interfacial interaction the provide structural reinforcement for transverse osseointegration regeneration, as evidenced by upregulated specific expressions collagen type-I, osteopontin, runt-related transcription factor 2. Meanwhile, thermal ablation synthesized nanoparticles mitochondrial dysfunction caused continuously released hydroxyapatite induce residual tumor necrosis synergistically. To validate capabilities inhibiting growth promoting regeneration our proposed scaffold, novel orthotopic model simulating treatment scenarios bone tumors established on rats. Based amounts vitro vivo results, effective suitable osteal-microenvironment modulation such composite are achieved, which provides insightful implications photonic hyperthermia therapy against following tissue

Language: Английский

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3D chitosan scaffolds loaded with ZnO nanoparticles for bone tissue engineering

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 245, P. 114199 - 114199

Published: Sept. 2, 2024

Language: Английский

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Piezoelectric Nanomaterial‐Mediated Physical Signals Regulate Cell Differentiation for Regenerative Medicine

Small Science, Journal Year: 2024, Volume and Issue: 4(3)

Published: Jan. 8, 2024

Tissue damage often causes considerable suffering to patients due slow recovery and poor prognosis. The use of electroactive materials deliver biophysical signals plays a key role in regulating tissue regeneration processes. Among these materials, piezoelectric have unique electromechanical conversion capabilities, making them suitable for as cell scaffolds. They can deform emit electrical response external stimuli, thereby proliferation differentiation. In this review, recent advances are presented physical signaling mediators that regulate basic mechanisms, classification their different applications described. Finally, comprehensive discussion current challenges prospects the field is provided. Together, existing experimental results basically show improve process effect repair, providing new technical options development engineering future.

Language: Английский

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Enhancing Ultrasound Power Transfer: Efficiency, Acoustics, and Future Directions

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 23, 2024

Abstract Implantable medical devices (IMDs), like pacemakers regulating heart rhythm or deep brain stimulators treating neurological disorders, revolutionize healthcare. However, limited battery life necessitates frequent surgeries for replacements. Ultrasound power transfer (UPT) emerges as a promising solution sustainable IMD operation. Current research prioritizes implantable materials, with less emphasis on sound field analysis and maximizing energy during wireless delivery. This review addresses this gap. A comprehensive of UPT technology, examining cutting‐edge system designs, particularly in supply efficiency is provided. The critically examines existing models, summarizing the key parameters influencing transmission systems. For first time, an flow diagram general proposed to offer insights into overall functioning. Additionally, explores development stages showcasing representative designs applications. remaining challenges, future directions, exciting opportunities associated are discussed. By highlighting importance IMDs advanced functions biosensing closed‐loop drug delivery, well UPT's potential, aims inspire further advancements field.

Language: Английский

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