Highly stable and near-infrared responsive phase change materials for targeted enzyme delivery toward cancer therapy DOI Creative Commons
Yuqiong Xia, Chang Liu,

Xuejuan Zhao

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101345 - 101345

Published: Nov. 19, 2024

Natural enzyme-based catalytic cascades have garnered increasing attention in cancer therapy, but their clinical utility is greatly limited due to loss of function during

Language: Английский

UiO-based platforms in biomedicine: Advanced nanovehicles for effective treatment DOI

Ren Zhang,

Abdulnasser Mahmoud Karami,

Qianying Huang

et al.

Materials Today Chemistry, Journal Year: 2025, Volume and Issue: 45, P. 102645 - 102645

Published: March 22, 2025

Language: Английский

Citations

1
Synchronously Evoking Disulfidptosis and Ferroptosis via Systematical Glucose Deprivation Targeting SLC7A11/GSH/GPX4 Antioxidant Axis DOI

Mengsi Zhang,

Hao Zheng,

Xuanqi Zhu

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Disulfidptosis and ferroptosis are recently identified programmed cell deaths for tumor therapy, both of which highly depend on the intracellular cystine/cysteine transformation cystine transporter solute carrier family 7 member 11/glutathione/glutathione peroxidase 4 (SLC7A11/GSH/GPX4) antioxidant axis. However, disulfidptosis usually asynchronous due to opposite effect transport them. Herein, systematic glucose deprivation, by inhibiting upstream uptake promoting downstream consumption, is proposed synchronously evoke ferroptosis. As an example, Au nanodots Fe-apigenin (Ap) complexes coloaded FeOOH nanoshuttles (FeOOH@Fe-Ap@Au NSs) employed regulate SLC7A11/GSH/GPX4 axis performing disulfidptosis- ferroptosis-mediated therapy synchronously. In this scenario, exhibit oxidase-like activity when consuming massive glucose. Meanwhile, Ap can inhibit downregulating 1, depriving fundamentally. The systematical deprivation limits supplement NADPH suppresses axis, thus solving contradiction addition, efficient delivery exogenous iron ions FeOOH@Fe-Ap@Au NSs self-supplied H2O2 through nanodots-catalytic oxidation facilitate Fenton reaction therewith help amplify a result synchronous occurrence ferroptosis, good efficacy in ovarian cancer therapeutic model.

Language: Английский

Citations

1
A biomimetic lubricating nanosystem for synergistic therapy of osteoarthritis DOI
Peiwei Gong, Meng Wang, Jiangli Wang

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 672, P. 589 - 599

Published: June 3, 2024

Language: Английский

Citations

7
A Powerful Tumor Catalytic Therapy by an Enzyme‐Nanozyme Cascade Catalysis (ENCAT) System DOI Open Access
Min Zhou,

Jiayuan Feng,

Qi Mei

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Complexity of tumor and its microenvironment as obstacles often restrict traditional therapies. Enzyme/nanozyme‐mediated catalytic therapy has been emerged, but the efficacy single is still moderate. Inspired by concepts synergetic therapy, an enzyme‐nanozyme cascade catalysis (ENCAT)‐enhanced developed. First, metal–organic framework (MOF) PCN222‐Mn (PM) glucose oxidase (GOx) are chosen nanozyme natural enzyme, respectively. Then two assembled together to form complex PCN222‐Mn@GOx (PMG). To achieve targeting GOx protection, hyaluronic acid (HA) modified on PMG obtain PCN222‐Mn@GOx/HA (PMGH). Both cellular animal studies demonstrate a catalysis‐enhanced PMGH. Specifically, PDT achieved based mediated cascade‐catalyzed O 2 generation; enhanced synergistic demonstrated combining PM‐mediated PDT, GOx‐mediated starvation activated/promoted immunotherapy together. Additionally, designed explored in bearing mouse model, where it exhibits powerful anti‐tumor effects against both primary metastatic tumors. This strategy potential broaden therapeutic approaches.

Language: Английский

Citations

0
Advances in metal-organic framework-based drug delivery systems DOI

M T Khulood,

U. S. Jijith,

Punnoth Poonkuzhi Naseef

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125380 - 125380

Published: Feb. 1, 2025

Language: Английский

Citations

0
sEmerging glucose oxidase-delivering nanomedicines for enhanced tumor therapy DOI

Kai‐Yue Song,

Ming Jiang, Bailong Tao

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113580 - 113580

Published: Feb. 28, 2025

Language: Английский

Citations

0
Silicon-based fluorescent drug delivery composites based on silver nanowires for non-small cell lung cancer therapy DOI
Yihua Zhu, Liming Ying, Hui Hui

et al.

Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 138444 - 138444

Published: March 1, 2025

Language: Английский

Citations

0
Folic acid-targeted macrophage membrane-coated carbon quantum dot nanoplatform for dual drug and gene delivery in metastatic osteosarcoma therapy DOI Creative Commons

Enyang Yao,

Yang Li, Kai Deng

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163227 - 163227

Published: April 1, 2025

Language: Английский

Citations

0
Dynamic processes of positive/negative immune-vascular crosstalk loop via functional MRI-guided monitor DOI
Rong Zhang, Teng Jin, Yanlong Zhang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 493, P. 152674 - 152674

Published: May 31, 2024

Language: Английский

Citations

1
Influence of bonding variance on electron affinity in graphene quantum dot-barium titanate nanocomposites for drug delivery system DOI

Jung-Hua Lin,

Li Chen, Er-Chieh Cho

et al.

FlatChem, Journal Year: 2024, Volume and Issue: 47, P. 100713 - 100713

Published: July 14, 2024

Language: Английский

Citations

1