The EMBO Journal, Journal Year: 2015, Volume and Issue: 34(10), P. 1349 - 1370
Published: March 21, 2015
Language: Английский
The EMBO Journal, Journal Year: 2015, Volume and Issue: 34(10), P. 1349 - 1370
Published: March 21, 2015
Language: Английский
Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282
Published: Jan. 25, 2021
Language: Английский
Citations
4596Cancer Cell, Journal Year: 2016, Volume and Issue: 29(6), P. 783 - 803
Published: June 1, 2016
Language: Английский
Citations
1663Genes & Development, Journal Year: 2016, Volume and Issue: 30(1), P. 1 - 17
Published: Jan. 1, 2016
The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied both mammals the last several years. core of consists kinase cascade, transcription coactivators, DNA-binding partners. Recent studies have expanded as complex signaling network with >30 components. This is regulated by intrinsic cell machineries, such cell–cell contact, polarity, actin cytoskeleton, well wide range signals, including cellular energy status, mechanical cues, hormonal signals that act through G-protein-coupled receptors. major functions defined to restrict adults modulate proliferation, differentiation, migration developing organs. Furthermore, dysregulation leads aberrant neoplasia. In this review, we focus on recent developments our understanding molecular actions cascade discuss key open questions regulation function pathway.
Language: Английский
Citations
1469Cell, Journal Year: 2017, Volume and Issue: 171(6), P. 1397 - 1410.e14
Published: Oct. 26, 2017
Language: Английский
Citations
1202Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 758 - 770
Published: Sept. 27, 2017
Language: Английский
Citations
1112Nature Cell Biology, Journal Year: 2015, Volume and Issue: 17(9), P. 1218 - 1227
Published: Aug. 10, 2015
Language: Английский
Citations
1074International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(10), P. 3028 - 3028
Published: Oct. 4, 2018
The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. ECM is highly dynamic as it constantly deposited, remodelled, degraded during development until maturity to maintain tissue homeostasis. ECM’s composition organization are spatiotemporally regulated control behaviour differentiation, but dysregulation dynamics leads the diseases such cancer. chemical cues presented by have been appreciated key drivers for both cancer progression. However, mechanical forces present due largely ignored recently recognized play critical roles in disease progression malignant behaviour. Here, we review ways which microenvironment regulation phenotype stages human
Language: Английский
Citations
967Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899
Published: July 19, 2018
Language: Английский
Citations
841Molecular Cell, Journal Year: 2022, Volume and Issue: 82(12), P. 2215 - 2227
Published: April 6, 2022
Language: Английский
Citations
687Cell, Journal Year: 2015, Volume and Issue: 162(4), P. 780 - 794
Published: Aug. 1, 2015
Language: Английский
Citations
623