Aerobic glycolysis tunes YAP / TAZ transcriptional activity DOI
Elena Enzo,

Giulia Santinon,

Arianna Pocaterra

et al.

The EMBO Journal, Journal Year: 2015, Volume and Issue: 34(10), P. 1349 - 1370

Published: March 21, 2015

Language: Английский

Ferroptosis: mechanisms, biology and role in disease DOI
Xuejun Jiang, Brent R. Stockwell, Marcus Conrad

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282

Published: Jan. 25, 2021

Language: Английский

Citations

4596

YAP/TAZ at the Roots of Cancer DOI Creative Commons

Francesca Zanconato,

Michelangelo Cordenonsi, Stefano Piccolo

et al.

Cancer Cell, Journal Year: 2016, Volume and Issue: 29(6), P. 783 - 803

Published: June 1, 2016

Language: Английский

Citations

1663

Mechanisms of Hippo pathway regulation DOI Open Access
Zhipeng Meng, Toshiro Moroishi, Kun‐Liang Guan

et al.

Genes & Development, Journal Year: 2016, Volume and Issue: 30(1), P. 1 - 17

Published: Jan. 1, 2016

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied both mammals the last several years. core of consists kinase cascade, transcription coactivators, DNA-binding partners. Recent studies have expanded as complex signaling network with >30 components. This is regulated by intrinsic cell machineries, such cell–cell contact, polarity, actin cytoskeleton, well wide range signals, including cellular energy status, mechanical cues, hormonal signals that act through G-protein-coupled receptors. major functions defined to restrict adults modulate proliferation, differentiation, migration developing organs. Furthermore, dysregulation leads aberrant neoplasia. In this review, we focus on recent developments our understanding molecular actions cascade discuss key open questions regulation function pathway.

Language: Английский

Citations

1469

Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores DOI Creative Commons

Alberto Elósegui-Artola,

Ion Andreu, Amy E. M. Beedle

et al.

Cell, Journal Year: 2017, Volume and Issue: 171(6), P. 1397 - 1410.e14

Published: Oct. 26, 2017

Language: Английский

Citations

1202

Mechanobiology of YAP and TAZ in physiology and disease DOI
Tito Panciera, Luca Azzolin, Michelangelo Cordenonsi

et al.

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 758 - 770

Published: Sept. 27, 2017

Language: Английский

Citations

1112

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth DOI

Francesca Zanconato,

Mattia Forcato,

Giusy Battilana

et al.

Nature Cell Biology, Journal Year: 2015, Volume and Issue: 17(9), P. 1218 - 1227

Published: Aug. 10, 2015

Language: Английский

Citations

1074

Role of Extracellular Matrix in Development and Cancer Progression DOI Open Access
Cameron Walker,

Elijah Mojares,

Armando E. del Río Hernández

et al.

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(10), P. 3028 - 3028

Published: Oct. 4, 2018

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. ECM is highly dynamic as it constantly deposited, remodelled, degraded during development until maturity to maintain tissue homeostasis. ECM’s composition organization are spatiotemporally regulated control behaviour differentiation, but dysregulation dynamics leads the diseases such cancer. chemical cues presented by have been appreciated key drivers for both cancer progression. However, mechanical forces present due largely ignored recently recognized play critical roles in disease progression malignant behaviour. Here, we review ways which microenvironment regulation phenotype stages human

Language: Английский

Citations

967

YAP/TAZ upstream signals and downstream responses DOI
Antonio Totaro, Tito Panciera, Stefano Piccolo

et al.

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899

Published: July 19, 2018

Language: Английский

Citations

841

Ferroptosis at the intersection of lipid metabolism and cellular signaling DOI Creative Commons
Deguang Liang, Alexander M. Minikes, Xuejun Jiang

et al.

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(12), P. 2215 - 2227

Published: April 6, 2022

Language: Английский

Citations

687

Alternative Wnt Signaling Activates YAP/TAZ DOI Creative Commons
Hyun Woo Park, Young Chul Kim, Bo Yu

et al.

Cell, Journal Year: 2015, Volume and Issue: 162(4), P. 780 - 794

Published: Aug. 1, 2015

Language: Английский

Citations

623