Ferroptosis: mechanisms, biology and role in disease

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 22(4), P. 266 - 282

Published: Jan. 25, 2021

Language: Английский

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YAP/TAZ at the Roots of Cancer

Cancer Cell, Journal Year: 2016, Volume and Issue: 29(6), P. 783 - 803

Published: June 1, 2016

Language: Английский

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Mechanisms of Hippo pathway regulation

Genes & Development, Journal Year: 2016, Volume and Issue: 30(1), P. 1 - 17

Published: Jan. 1, 2016

The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied both mammals the last several years. core of consists kinase cascade, transcription coactivators, DNA-binding partners. Recent studies have expanded as complex signaling network with >30 components. This is regulated by intrinsic cell machineries, such cell–cell contact, polarity, actin cytoskeleton, well wide range signals, including cellular energy status, mechanical cues, hormonal signals that act through G-protein-coupled receptors. major functions defined to restrict adults modulate proliferation, differentiation, migration developing organs. Furthermore, dysregulation leads aberrant neoplasia. In this review, we focus on recent developments our understanding molecular actions cascade discuss key open questions regulation function pathway.

Language: Английский

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Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores

Cell, Journal Year: 2017, Volume and Issue: 171(6), P. 1397 - 1410.e14

Published: Oct. 26, 2017

Language: Английский

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Mechanobiology of YAP and TAZ in physiology and disease

Nature Reviews Molecular Cell Biology, Journal Year: 2017, Volume and Issue: 18(12), P. 758 - 770

Published: Sept. 27, 2017

Language: Английский

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Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

Nature Cell Biology, Journal Year: 2015, Volume and Issue: 17(9), P. 1218 - 1227

Published: Aug. 10, 2015

Language: Английский

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Role of Extracellular Matrix in Development and Cancer Progression

International Journal of Molecular Sciences, Journal Year: 2018, Volume and Issue: 19(10), P. 3028 - 3028

Published: Oct. 4, 2018

The immense diversity of extracellular matrix (ECM) proteins confers distinct biochemical and biophysical properties that influence cell phenotype. ECM is highly dynamic as it constantly deposited, remodelled, degraded during development until maturity to maintain tissue homeostasis. ECM’s composition organization are spatiotemporally regulated control behaviour differentiation, but dysregulation dynamics leads the diseases such cancer. chemical cues presented by have been appreciated key drivers for both cancer progression. However, mechanical forces present due largely ignored recently recognized play critical roles in disease progression malignant behaviour. Here, we review ways which microenvironment regulation phenotype stages human

Language: Английский

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YAP/TAZ upstream signals and downstream responses

Nature Cell Biology, Journal Year: 2018, Volume and Issue: 20(8), P. 888 - 899

Published: July 19, 2018

Language: Английский

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Ferroptosis at the intersection of lipid metabolism and cellular signaling

Molecular Cell, Journal Year: 2022, Volume and Issue: 82(12), P. 2215 - 2227

Published: April 6, 2022

Language: Английский

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Alternative Wnt Signaling Activates YAP/TAZ

Cell, Journal Year: 2015, Volume and Issue: 162(4), P. 780 - 794

Published: Aug. 1, 2015

Language: Английский

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