Journal of Cell Science,
Journal Year:
2014,
Volume and Issue:
127(4), P. 709 - 717
Published: Feb. 14, 2014
ABSTRACT
The
Hippo-YAP
pathway
mediates
the
control
of
cell
proliferation
by
contact
inhibition
as
well
other
attributes
physical
state
cells
in
tissues.
Several
mechanisms
sense
spatial
and
organization
cells,
function
through
distinct
upstream
modules
to
stimulate
signaling:
adherens
junction
or
cadherin–catenin
complexes,
epithelial
polarity
tight
FAT-Dachsous
morphogen
pathway,
shape,
actomyosin
mechanotransduction.
Soluble
extracellular
factors
also
regulate
Hippo
signaling,
often
inhibiting
its
activity.
Indeed,
a
reciprocal
relationship
between
mitogenic
signaling.
As
result,
at
edges
colony,
wound
tissue
tumor
are
more
sensitive
ambient
levels
growth
likely
proliferate,
migrate
differentiate
YAP
and/or
TAZ-dependent
process.
Thus,
senses
responds
tissues
coordinates
these
cues
with
classic
growth-factor-mediated
signaling
pathways.
This
Commentary
is
focused
on
biological
significance
how
regulatory
interact
produce
outcomes.
Genes & Development,
Journal Year:
2016,
Volume and Issue:
30(1), P. 1 - 17
Published: Jan. 1, 2016
The
Hippo
pathway
was
initially
identified
in
Drosophila
melanogaster
screens
for
tissue
growth
two
decades
ago
and
has
been
a
subject
extensively
studied
both
mammals
the
last
several
years.
core
of
consists
kinase
cascade,
transcription
coactivators,
DNA-binding
partners.
Recent
studies
have
expanded
as
complex
signaling
network
with
>30
components.
This
is
regulated
by
intrinsic
cell
machineries,
such
cell–cell
contact,
polarity,
actin
cytoskeleton,
well
wide
range
signals,
including
cellular
energy
status,
mechanical
cues,
hormonal
signals
that
act
through
G-protein-coupled
receptors.
major
functions
defined
to
restrict
adults
modulate
proliferation,
differentiation,
migration
developing
organs.
Furthermore,
dysregulation
leads
aberrant
neoplasia.
In
this
review,
we
focus
on
recent
developments
our
understanding
molecular
actions
cascade
discuss
key
open
questions
regulation
function
pathway.
Cold Spring Harbor Perspectives in Medicine,
Journal Year:
2015,
Volume and Issue:
5(4), P. a006098 - a006098
Published: April 1, 2015
Richard
Sever1
and
Joan
S.
Brugge2
1Cold
Spring
Harbor
Laboratory,
Cold
Harbor,
New
York
11724
2Harvard
Medical
School,
Department
of
Cell
Biology,
Boston,
Massachusetts
02115
Correspondence:
joan_brugge{at}hms.harvard.edu
Cold Spring Harbor Perspectives in Biology,
Journal Year:
2016,
Volume and Issue:
9(1), P. a022137 - a022137
Published: Nov. 11, 2016
Cytokines
of
the
transforming
growth
factor
β
(TGF-β)
family,
including
TGF-βs,
bone
morphogenic
proteins
(BMPs),
activins,
and
Nodal,
play
crucial
roles
in
embryonic
development
adult
tissue
homeostasis
by
regulating
cell
proliferation,
survival,
differentiation,
as
well
stem-cell
self-renewal
lineage-specific
differentiation.
Smad
are
critical
downstream
mediators
these
signaling
activities.
In
addition
to
transcription
direct
target
genes
TGF-β,
BMP,
activin,
or
also
participate
extensive
cross
talk
with
other
pathways,
often
a
cell-type-
developmental
stage-specific
manner.
These
combinatorial
signals
produce
context-,
time-,
location-dependent
biological
outcomes
that
for
development.
This
review
discusses
recent
progress
our
understanding
between
pathways
Wnt,
Notch,
Hippo,
Hedgehog
(Hh),
mitogen-activated
protein
(MAP),
kinase,
phosphoinositide
3-kinase
(PI3K)-Akt,
nuclear
κB
(NF-κB),
Janus
kinase/signal
transducers
activators
(JAK/STAT)
pathways.
