Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Nature Medicine, Journal Year: 2016, Volume and Issue: 22(6), P. 586 - 597

Published: May 9, 2016

Language: Английский

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The IL-17 Family of Cytokines in Health and Disease

Immunity, Journal Year: 2019, Volume and Issue: 50(4), P. 892 - 906

Published: April 1, 2019

Language: Английский

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Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

Nature Reviews Neurology, Journal Year: 2016, Volume and Issue: 13(1), P. 25 - 36

Published: Dec. 9, 2016

Language: Английский

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Regulation of the Immune Response by the Aryl Hydrocarbon Receptor

Immunity, Journal Year: 2018, Volume and Issue: 48(1), P. 19 - 33

Published: Jan. 1, 2018

Language: Английский

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Melatonin as a Hormone: New Physiological and Clinical Insights

Endocrine Reviews, Journal Year: 2018, Volume and Issue: 39(6), P. 990 - 1028

Published: Sept. 12, 2018

Melatonin is a ubiquitous molecule present in almost every live being from bacteria to humans. In vertebrates, besides produced peripheral tissues and acting as an autocrine paracrine signal, melatonin centrally synthetized by neuroendocrine organ, the pineal gland. Independently of considered species, hormone always during night its production secretory episode duration are directly dependent on length night. As tightly linked light/dark cycle, main hormonal systemic integrative action coordinate behavioral physiological adaptations environmental geophysical day season. The circadian signal daily regularity, contrast between concentrations, specially developed ways action. During episode, coordinates adaptive physiology through immediate effects primes responses prospective that will only appear at daytime, when absent. Similarly, annual history central nervous/endocrine system seasons come. Remarkably, maternal programs fetuses' behavior cope with cycle season after birth. These unique turn into biological time-domain–acting molecule. review focuses above considerations, proposes putative classification clinical dysfunctions, discusses general guidelines therapeutic use melatonin.

Language: Английский

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Clocking in to immunity

Nature reviews. Immunology, Journal Year: 2018, Volume and Issue: 18(7), P. 423 - 437

Published: April 16, 2018

Language: Английский

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Update on melatonin receptors: IUPHAR Review 20

British Journal of Pharmacology, Journal Year: 2016, Volume and Issue: 173(18), P. 2702 - 2725

Published: June 17, 2016

Melatonin receptors are seven transmembrane‐spanning proteins belonging to the GPCR superfamily. In mammals, two melatonin receptor subtypes exist ‐ MT 1 and 2 encoded by MTNR1A MTNR1B genes respectively. The current review provides an update on corresponding subcommittee of International Union Basic Clinical Pharmacology. We will highlight recent developments ligands, including radioligands, give latest phenotyping results knockout mice. status perspectives structure be summarized. physiological importance dimers biologically important type diabetes‐associated genetic variants discussed. role in physiology disease further exemplified their functions immune system CNS. Finally, antioxidant free radical scavenger properties its relation critically addressed.

Language: Английский

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The dichotomous nature of T helper 17 cells

Nature reviews. Immunology, Journal Year: 2017, Volume and Issue: 17(9), P. 535 - 544

Published: May 30, 2017

Language: Английский

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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(38)

Published: Sept. 5, 2017

G protein-coupled receptors (GPCRs) are classically characterized as cell-surface transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised the melatonin type 1 receptor (MT

Language: Английский

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Multifaceted interactions between adaptive immunity and the central nervous system

Science, Journal Year: 2016, Volume and Issue: 353(6301), P. 766 - 771

Published: Aug. 18, 2016

Neuroimmunologists seek to understand the interactions between central nervous system (CNS) and immune system, both under homeostatic conditions in diseases. Unanswered questions include those relating diversity specificity of meningeal T cell repertoire; routes taken by cells that patrol meninges healthy invade parenchyma during pathology; opposing effects (beneficial or detrimental) these on CNS function; role after injury; evolutionary link two systems, resulting their tight interaction interdependence. This Review summarizes current standing challenging related adaptive immunity considers possible directions which aspects neuroimmunology will be heading over next decade.

Language: Английский

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