Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

Cell Host & Microbe, Journal Year: 2018, Volume and Issue: 23(6), P. 716 - 724

Published: June 1, 2018

Language: Английский

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How neuroinflammation contributes to neurodegeneration

Science, Journal Year: 2016, Volume and Issue: 353(6301), P. 777 - 783

Published: Aug. 18, 2016

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most pressing problems of developed societies with aging populations. Neurons carry out essential functions signal transmission network integration in central nervous system main targets neurodegenerative disease. In this Review, I address how neuron's environment also contributes to neurodegeneration. Maintaining an optimal milieu for neuronal function rests supportive cells termed glia blood-brain barrier. Accumulating evidence suggests that neurodegeneration occurs part because is affected during disease a cascade processes collectively neuroinflammation. These observations indicate therapies targeting glial might provide benefit those afflicted by disorders.

Language: Английский

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Interactions between the microbiota, immune and nervous systems in health and disease

Nature Neuroscience, Journal Year: 2017, Volume and Issue: 20(2), P. 145 - 155

Published: Jan. 16, 2017

Language: Английский

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Microbial tryptophan catabolites in health and disease

Nature Communications, Journal Year: 2018, Volume and Issue: 9(1)

Published: Aug. 13, 2018

Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These suggested to activate the immune system through binding aryl hydrocarbon receptor (AHR), enhance intestinal epithelial barrier, stimulate gastrointestinal motility, well secretion hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate composition. Tryptophan thus affect various physiological processes may contribute homeostasis health disease.

Language: Английский

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Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

Nature Reviews Drug Discovery, Journal Year: 2019, Volume and Issue: 18(5), P. 379 - 401

Published: Feb. 13, 2019

Language: Английский

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Salt-responsive gut commensal modulates TH17 axis and disease

Nature, Journal Year: 2017, Volume and Issue: 551(7682), P. 585 - 589

Published: Nov. 1, 2017

Language: Английский

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Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity

Cell, Journal Year: 2016, Volume and Issue: 167(4), P. 1125 - 1136.e8

Published: Nov. 1, 2016

Language: Английский

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The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(3), P. 184 - 197

Published: Feb. 4, 2019

Language: Английский

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Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models

Proceedings of the National Academy of Sciences, Journal Year: 2017, Volume and Issue: 114(40), P. 10713 - 10718

Published: Sept. 11, 2017

Significance We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). identified specific bacteria that are associated with MS and demonstrated these regulate T lymphocyte-mediated adaptive immune responses contribute to proinflammatory environment vitro vivo. Thus, our results expand knowledge microbial regulation immunity may provide a basis for development microbiome-based therapeutics autoimmune diseases.

Language: Английский

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Microglial control of astrocytes in response to microbial metabolites

Nature, Journal Year: 2018, Volume and Issue: 557(7707), P. 724 - 728

Published: May 1, 2018

Language: Английский

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