Wireless and battery-free technologies for neuroengineering

Nature Biomedical Engineering, Journal Year: 2021, Volume and Issue: 7(4), P. 405 - 423

Published: March 8, 2021

Language: Английский

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Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids

Science Advances, Journal Year: 2021, Volume and Issue: 7(12)

Published: March 17, 2021

3D multifunctional frameworks, as flexible a single strand of silk, modulate and measure neural activity brain spheroids.

Language: Английский

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Deep brain optogenetics without intracranial surgery

Nature Biotechnology, Journal Year: 2020, Volume and Issue: 39(2), P. 161 - 164

Published: Oct. 5, 2020

Language: Английский

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Cardiogenic control of affective behavioural state

Nature, Journal Year: 2023, Volume and Issue: 615(7951), P. 292 - 299

Published: March 1, 2023

Abstract Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of heart 1–3 . However, whether an increased rate might itself induce or fear responses is unclear 3–8 Physiological theories emotion, proposed over a century ago, have considered that general, there could be important and even dominant flow information from body to brain 9 Here, formally test this idea, we developed noninvasive optogenetic pacemaker for precise, cell-type-specific control cardiac rhythms up 900 beats per minute freely moving mice, enabled wearable micro-LED harness systemic viral delivery potent pump-like channelrhodopsin. We found optically evoked tachycardia potently enhanced anxiety-like behaviour, but crucially only risky contexts, indicating both central (brain) peripheral (body) processes may involved development emotional states. To identify potential mechanisms, used whole-brain activity screening electrophysiology find regions were activated imposed rhythms. identified posterior insular cortex mediator bottom-up interoceptive processing, inhibition region attenuated behaviour was induced optical pacing. Together, these findings reveal cells must together understand origins affective More broadly, our results define generalizable approach noninvasive, temporally precise functional investigations joint organism-wide interactions among targeted during behaviour.

Language: Английский

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Hybrid Energy-Harvesting Systems Based on Triboelectric Nanogenerators

Matter, Journal Year: 2021, Volume and Issue: 4(1), P. 116 - 143

Published: Jan. 1, 2021

Language: Английский

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Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: Jan. 22, 2021

Abstract Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation brain more natural conditions by releasing animals from tethered optical fibers. However, current implants, which are largely based on battery-powered or battery-free designs, still limit the full potential vivo freely moving requiring intermittent battery replacement special, bulky power transfer system continuous device operation, respectively. To address these limitations, here we present wirelessly rechargeable, fully implantable, soft optoelectronic can be remotely selectively controlled using smartphone. Combining advantageous features both this enables seamless implantation into animals, reliable ubiquitous intervention-free charging, all desired chronic optogenetics. Successful demonstration unique capabilities behaving rats forecasts its broad practical utilities various neuroscience research clinical applications.

Language: Английский

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Self‐Shaping Soft Electronics Based on Patterned Hydrogel with Stencil‐Printed Liquid Metal

Advanced Functional Materials, Journal Year: 2021, Volume and Issue: 31(47)

Published: Aug. 27, 2021

Abstract Hydrogel‐based soft electronics (HSE) is promising as implantable devices due to the similarity of hydrogel substrates biologic tissues. Most existing HSE are based on conducting hydrogels that usually have weak mechanical properties, low conductivity, and poor patternability. Reported here an with good performance, high sensitivity, versatile functions by stencil printing liquid metal a tough hydrogel, facilitating integration multiple sensing units. Self‐shaping ability imparted creating gradient structure in substrate. The resultant actively deforms into 3D configurations zero or nonzero Gaussian curvature fix objects organs sophisticated geometries maintains functions. versatilities potential applications this demonstrated monitoring motions rice field eel beatings rabbit heart. Such morphing substrate should pave way for better fixation interfacial contact organs. concept can be extended other responsive polymer films elastomers substrates.

Language: Английский

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Bioadhesive and conductive hydrogel-integrated brain-machine interfaces for conformal and immune-evasive contact with brain tissue

Matter, Journal Year: 2022, Volume and Issue: 5(4), P. 1204 - 1223

Published: Jan. 31, 2022

Language: Английский

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Remotely controlled near-infrared-triggered photothermal treatment of brain tumours in freely behaving mice using gold nanostars

Nature Nanotechnology, Journal Year: 2022, Volume and Issue: 17(9), P. 1015 - 1022

Published: Aug. 22, 2022

Language: Английский

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High-efficiency stretchable light-emitting polymers from thermally activated delayed fluorescence

Nature Materials, Journal Year: 2023, Volume and Issue: 22(6), P. 737 - 745

Published: April 6, 2023

Language: Английский

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