Langmuir,
Journal Year:
2022,
Volume and Issue:
38(38), P. 11503 - 11513
Published: Sept. 16, 2022
Hydrogels
have
emerged
as
multifunctional
interface
materials
between
implantable
bioelectronic
devices
and
biotissues.
The
soft
wet
with
low
alterable
mechanical
properties
can
match
the
mechanical,
chemical,
electrical,
biological
of
biotissues
thus
diminish
electrical
mismatch.
Interactions
at
hydrogel–biotissue
hydrogel–device
interfaces
attracted
broad
research
interest.
Great
efforts
been
devoted
to
establishing
instant,
strong,
conformal
adhesion
by
chemical
bonding,
electrostatic
interaction,
hydrogen
supramolecular
recognition,
hydrophobic
association,
even
topological
entanglements
interfaces.
This
Perspective
provides
a
brief
account
representative
progress
on
hydrogel–tissue
adhesive
that
forms
seamless
applications
in
for
physiological,
cardiac,
neuronal
signal
collection
stimulation.
Major
challenges
such
stability
are
identified
examination
future
investigations.
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
52(2), P. 473 - 509
Published: Dec. 9, 2022
Hydrogel-based
conductive
materials
for
smart
wearable
devices
have
attracted
increasing
attention
due
to
their
excellent
flexibility,
versatility,
and
outstanding
biocompatibility.
This
review
presents
the
recent
advances
in
multifunctional
hydrogels
electronic
devices.
First,
with
different
components
are
discussed,
including
pure
single
network
based
on
polymers,
additional
additives
(i.e.,
nanoparticles,
nanowires,
nanosheets),
double
additives.
Second,
a
variety
of
functionalities,
self-healing,
super
toughness,
self-growing,
adhesive,
anti-swelling,
antibacterial,
structural
color,
hydrophobic,
anti-freezing,
shape
memory
external
stimulus
responsiveness
introduced
detail.
Third,
applications
flexible
illustrated
strain
sensors,
supercapacitors,
touch
panels,
triboelectric
nanogenerator,
bioelectronic
devices,
robot).
Next,
current
challenges
facing
summarized.
Finally,
an
imaginative
but
reasonable
outlook
is
given,
which
aims
drive
further
development
future.
Bioactive Materials,
Journal Year:
2022,
Volume and Issue:
18, P. 213 - 227
Published: March 22, 2022
Regenerating
periodontal
bone
tissues
in
the
aggravated
inflammatory
microenvironment
under
diabetic
conditions
is
a
great
challenge.
Here,
polydopamine-mediated
graphene
oxide
(PGO)
and
hydroxyapatite
nanoparticle
(PHA)-incorporated
conductive
alginate/gelatin
(AG)
scaffold
developed
to
accelerate
regeneration
by
modulating
microenvironment.
PHA
confers
with
osteoinductivity
PGO
provides
pathway
for
scaffold.
The
promotes
transferring
endogenous
electrical
signals
cells
activating
Ca2+
channels.
Moreover,
nanomaterials
has
reactive
oxygen
species
(ROS)-scavenging
ability
anti-inflammatory
activity.
It
also
exhibits
an
immunomodulatory
that
suppresses
M1
macrophage
polarization
activates
M2
macrophages
secrete
osteogenesis-related
cytokines
mediating
glycolytic
RhoA/ROCK
pathways
macrophages.
induces
excellent
defects
of
rats
because
synergistic
effects
good
conductive,
ROS-scavenging,
anti-inflammatory,
abilities.
This
study
fundamental
insights
into
synergistical
conductivity,
osteoinductivity,
abilities
on
offers
novel
strategy
design
biomaterials
treatment
immune-related
diseases
tissue
regeneration.
ACS Nano,
Journal Year:
2023,
Volume and Issue:
17(3), P. 2745 - 2760
Published: Feb. 3, 2023
Hydrogels
with
robust
wet
adhesion
are
desirable
for
applications
in
aqueous
environments.
Wet
arising
from
synergy
between
hydrophobic
and
catechol
components
mussel
foot
proteins
has
been
highlighted.
However,
optimizing
hydrogels
multiple
is
challenging
because
of
their
complex
structure–property
relationships.
Herein,
high-throughput
screening
a
series
alkyl
monomers
adhesive
derivatives
was
used
to
systematically
develop
hydrogels.
Short
chains
promote
by
repelling
water
at
the
interface,
whereas
long
form
strong
interactions
inside
hydrogel
network
that
impede
or
dissipate
energy
adhesion.
The
optimized
hydrogel,
containing
short
chain,
applied
rapid
hemostasis
wound
healing
synergistic
effect
groups
its
immunomodulation
ability,
which
revealed
through
transcriptomic
analysis.
Conductive
nanocomponents
were
incorporated
into
produce
wearable
device,
continuous
monitoring
human
electrocardiogram
(ECG)
during
swimming,
situ
epicardial
ECG
on
porcine
living
beating
heart.
This
study
demonstrated
an
efficient
generalized
molecular
design
strategy
multifunctional
Science,
Journal Year:
2023,
Volume and Issue:
381(6658), P. 686 - 693
Published: Aug. 10, 2023
The
use
of
bioelectronic
devices
relies
on
direct
contact
with
soft
biotissues.
For
transistor-type
devices,
the
semiconductors
that
need
to
have
interfacing
biotissues
for
effective
signal
transduction
do
not
adhere
well
wet
tissues,
thereby
limiting
stability
and
conformability
at
interface.
We
report
a
bioadhesive
polymer
semiconductor
through
double-network
structure
formed
by
brush
redox-active
semiconducting
polymer.
resulting
film
can
form
rapid
strong
adhesion
tissue
surfaces
together
high
charge-carrier
mobility
~1
square
centimeter
per
volt
second,
stretchability,
good
biocompatibility.
Further
fabrication
fully
transistor
sensor
enabled
us
produce
high-quality
stable
electrophysiological
recordings
an
isolated
rat
heart
in
vivo
muscles.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
35(12)
Published: Jan. 9, 2023
Hydrogels
are
ideal
building
blocks
to
fabricate
the
next
generation
of
electrodes
for
acquiring
high-quality
physiological
electrical
signals,
example,
electroencephalography
(EEG).
However,
collection
EEG
signals
still
suffers
from
electrode
deformation,
sweating,
extensive
body
motion
and
vibration,
environmental
interference.
Herein,
polyvinyl
alcohol
polyvinylpyrrolidone
selected
prepare
a
hydrogel
network
with
tissue-like
modulus
excellent
flexibility.
Additionally,
polydopamine
nanoparticles,
obtained
by
peroxidation,
integrated
into
endow
them
higher
transparency,
self-adhesion,
lower
impedance.
Consequently,
multichannel
wirelessly
operated
can
establish
conformal
stable
interface
tissue
illustrate
high
channel
uniformity,
low
interfacial
contact
impedance,
power
noise,
long-term
stability,
tolerance
sweat
motion.
Furthermore,
shows
unprecedented
ability
classify
recorded
prefrontal
seven-category
sustained
attention
accuracy
(91.5%),
having
great
potential
applications
in
assessment
human
consciousness
multifunctional
diagnoses.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: Oct. 29, 2022
Abstract
The
development
of
flexible
thermistor
epidermal
electronics
(FTEE)
to
satisfy
high
temperature
resolution
without
strain
induced
signal
distortion
is
great
significance
but
still
challenging.
Inspired
by
the
nacre
microstructure
capable
restraining
stress
concentration,
we
exemplify
a
versatile
MXene-based
elastomer
sensor
(TES)
platform
that
significantly
alleviates
interference
biomimetic
laminated
strategy
combining
with
in-plane
dissipation
and
nacre-mimetic
hierarchical
architecture,
delivering
competitive
advantages
superior
thermosensitivity
(−1.32%
°C
−1
),
outstanding
(~0.3
°C),
unparalleled
mechanical
durability
(20000
folding
fatigue
cycles),
together
considerable
improvement
in
strain-tolerant
thermosensation
over
commercial
thermocouple
exercise
scenario.
By
combination
theoretical
model
simulation,
observation,
superposed
detection,
authors
further
reveal
underlying
decoupling
mechanism
substantiate
generality
customizability
strategy,
possessing
insightful
fabricating
FTEE
for
static
dynamic
detection.
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
123(24), P. 14084 - 14118
Published: Nov. 16, 2023
Bioadhesives
have
emerged
as
transformative
and
versatile
tools
in
healthcare,
offering
the
ability
to
attach
tissues
with
ease
minimal
damage.
These
materials
present
numerous
opportunities
for
tissue
repair
biomedical
device
integration,
creating
a
broad
landscape
of
applications
that
captivated
clinical
scientific
interest
alike.
However,
fully
unlocking
their
potential
requires
multifaceted
design
strategies
involving
optimal
adhesion,
suitable
biological
interactions,
efficient
signal
communication.
In
this
Review,
we
delve
into
these
pivotal
aspects
bioadhesive
design,
highlight
latest
advances
applications,
identify
lie
ahead
bioadhesives
multifunctional
technology
platforms.
