Recent advances in the epithelial barrier theory

International Immunology, Journal Year: 2024, Volume and Issue: 36(5), P. 211 - 222

Published: Jan. 16, 2024

Abstract The epithelial barrier theory links the recent rise in chronic non-communicable diseases, notably autoimmune and allergic disorders, to environmental agents disrupting barrier. Global pollution toxic agent exposure have worsened over six decades because of uncontrolled growth, modernization, industrialization, affecting human health. Introducing new chemicals without any reasonable control their health effects through these years has led documented adverse effects, especially on skin mucosal barriers. These substances, such as particulate matter, detergents, surfactants, food emulsifiers, micro- nano-plastics, diesel exhaust, cigarette smoke, ozone, been shown compromise integrity. This disruption is linked opening tight-junction barriers, inflammation, cell death, oxidative stress, metabolic regulation. Consideration must be given interplay underlying inflammatory medications, affected tissues. review article discusses detrimental effect barrier-damaging compounds involves cellular molecular mechanisms.

Language: Английский

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Environmental Toxicant Exposure and Depressive Symptoms

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(7), P. e2420259 - e2420259

Published: July 3, 2024

Importance Recognizing associations between exposure to common environmental toxicants and mental disorders such as depression is crucial for guiding targeted mechanism research the initiation of disease prevention efforts. Objectives To comprehensively screen assess potential depressive symptoms whether systemic inflammation serves a mediator. Design, Setting, Participants A total 3427 participants from 2013-2014 2015-2016 waves National Health Nutrition Examination Survey who had information on blood or urine concentrations scores assessed by 9-item Patient Questionnaire (PHQ-9) were included. Statistical analysis was performed July 1, 2023, January 31, 2024. Exposures Sixty-two in 10 categories included acrylamide, arsenic, ethylene oxide, formaldehyde, iodine, metals, nicotine metabolites, polycyclic aromatic hydrocarbons, volatile organic compound (VOC) metabolites; perchlorate, nitrate, thiocyanate. Main Outcomes Measures An exposome-wide association study deletion-substitution-addition algorithm used with (PHQ-9 ≥5) adjusted other important covariates. mediation framework evaluate mediating role peripheral white cell count. Results Among adults included, 1735 (50.6%) women, 2683 (78.3%) younger than 65 years, 744 (21.7%) years older, 839 (24.5%) having symptoms. In terms race ethnicity, 570 (16.6%) Mexican American, 679 (19.8%) non-Hispanic Black, 1314 (38.3%) White. We identified 27 chemical compounds metals 6 prevalence symptoms, including VOC metabolites N -acetyl- S -(2-hydroxy-3-butenyl)- l -cysteine (odds ratio [OR], 1.74 [95% CI, 1.38, 2.18]) equivalent-2 (OR, 1.42 1.26-1.59]). Men individuals appear more vulnerable women older individuals. Peripheral count mediated 5% 19% associations. Conclusions Relevance this representative cross-sectional toxicant exposures, associated inflammation. This provides insight into selecting targets mechanistic causes facilitating efforts reduce exposures.

Language: Английский

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Therapeutic detoxification of quercetin for aflatoxin B1-related toxicity: Roles of oxidative stress, inflammation, and metabolic enzymes

Environmental Pollution, Journal Year: 2024, Volume and Issue: 345, P. 123474 - 123474

Published: Feb. 1, 2024

Language: Английский

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From Cohorts to Molecules: Adverse Impacts of Endocrine Disrupting Mixtures

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2017, Volume and Issue: unknown

Published: Oct. 23, 2017

ABSTRACT Convergent evidence associates endocrine disrupting chemicals (EDCs) with major, increasingly-prevalent human disorders. Regulation requires elucidation of EDC-triggered molecular events causally linked to adverse health outcomes, but two factors limit their identification. First, experiments frequently use individual chemicals, whereas real life entails simultaneous exposure multiple EDCs. Second, population-based and experimental studies are seldom integrated. This drawback was exacerbated until recently by lack physiopathologically meaningful systems that link epidemiological data results from model organisms. We developed a novel approach, integrating evidence. Starting 1,874 mother-child pairs we identified mixtures measured during early pregnancy, associated language delay or low-birth weight in offspring. These were then tested on complementary vitro vivo models. demonstrate each EDC mixture, at levels found pregnant women, disrupts hormone-regulated disease-relevant gene regulatory networks both the cellular organismal scale.

Language: Английский

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The accelerated aging phenotype: The role of race and social determinants of health on aging

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 73, P. 101536 - 101536

Published: Dec. 6, 2021

Language: Английский

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