The Journal of Climate Change and Health, Journal Year: 2024, Volume and Issue: unknown, P. 100350 - 100350
Published: Oct. 1, 2024
Language: Английский
Current Allergy and Asthma Reports, Journal Year: 2024, Volume and Issue: 24(7), P. 331 - 345
Published: June 17, 2024
Abstract Purpose of Review Modernization and Westernization in industrialized developing nations is associated with a substantial increase chronic noncommunicable diseases. This transformation has far-reaching effects on lifestyles, impacting areas such as economics, politics, social life, culture, all which, turn, have diverse influences public health. Loss contact nature, alternations the microbiota, processed food consumption, exposure to environmental pollutants including chemicals, increased stress decreased physical activity jointly result increases frequency inflammatory disorders allergies many autoimmune neuropsychiatric review aims investigate relationship between Western lifestyle disorders. Recent Findings Several hypotheses been put forth trying explain observed these diseases, ‘ Hygiene Hypothesis ’, Old Friends Biodiversity Dysbiosi s’. The recently introduced Epithelial Barrier Theory ’ incorporates former suggests that toxic substances cleaning agents, laundry dishwasher detergents, shampoos, toothpastes, well microplastic, packaged air pollution damage epithelium our skin, lungs gastrointestinal system. barrier disruption leads biodiversity microbiome development opportunistic pathogen colonization, which upon interaction immune system, initiates local systemic inflammation. Summary Gaining deeper comprehension interplay environment, system provides data assist legally regulating usage substances, enable nontoxic alternatives mitigate challenges essential for fostering harmonious healthy global environment.
Language: Английский
Citations
15
Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332523
Published: Aug. 23, 2024
Epidemiological and translational data increasingly implicate environmental pollutants in inflammatory bowel disease (IBD). Indeed, the global incidence of IBD has been rising, particularly developing countries, parallel with increased use chemicals synthetic materials daily life escalating pollution levels. Recent nationwide ecological studies have reported associations between agricultural pesticides IBD, Crohn’s disease. Exposure to other chemical categories also linked an risk IBD. To synthesise available identify knowledge gaps, we conducted a systematic review human that on impact outcomes. Furthermore, summarised vitro animal investigating mechanisms underlying these associations. The 32 included corroborate heavy transition metals, except zinc, air pollutants, per- polyfluorinated substances, are associated exposure being disease-related adverse outcomes as well. narrative preclinical suggests several overlapping associations, including intestinal permeability, systemic inflammation dysbiosis. A consolidated understanding exposures is key identification potentially modifiable factors inform strategies towards prediction, prevention mitigation
Language: Английский
Citations
11
Current Treatment Options in Allergy, Journal Year: 2025, Volume and Issue: 12(1)
Published: Jan. 17, 2025
Abstract Purpose of Review Despite global incidence, considerable morbidity, and diverse triggers, CU is poorly characterized amongst African populations. This systematic review aims to describe available studies unmet needs. Recent Findings Overall 221 publications were screened 29 eligible for full review. These represented only 12 54 countries, with 38% from Nigeria. Most described within the context dermatology out-patient clinics(21/29), a prevalence 0.03–10.4%. Two detailed demographics, female predominance median age 30–40 years. patients reported variable associations infections, including T.canis (Egypt), H.pylori (Nigeria South Africa), other risk factors foods, food additives, low vitamin D levels. UAS was < 100 patients, two co-morbidities, while none addressed patient-reported outcome or quality-of-life measures, treatment access and/or efficacy. Summary disease prevalence, in Further are required detail phenotypes, severity use
Language: Английский
Citations
1
Allergy, Journal Year: 2025, Volume and Issue: 80(3), P. 651 - 676
Published: Feb. 28, 2025
ABSTRACT The EAACI Guidelines used the GRADE approach to evaluate impact of major indoor air pollutants (dampness and mould, cleaning agents, volatile organic compounds pesticides) on risk new‐onset asthma asthma‐related outcomes. guideline also acknowledges synergies among other components exposome (allergens, viruses, endotoxins). Very low certainty evidence was found for association between exposure increased worsening. Only mould there moderate asthma. Due quality evidence, conditional recommendations were formulated all pollutants. Recommendations are provided prevention, patient care mitigation in a framework supporting rational decisions healthcare professionals patients individualize improve management. For policymakers regulators this evidence‐informed supports setting legally binding standards goals at international, national local levels. Asthma management counselled by current guidelines can outcomes but community governmental measures improved needed achieve significant impact.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6913 - 6913
Published: June 24, 2024
Chronic exposure to harmful pollutants, chemicals, and pathogens from the environment can lead pathological changes in epithelial barrier, which increase risk of developing an allergy. During allergic inflammation, cells send proinflammatory signals group 2 innate lymphoid cell (ILC2s) eosinophils, require energy resources mediate their activation, cytokine/chemokine secretion, mobilization other cells. This review aims provide overview metabolic regulation asthma, atopic dermatitis (AD), rhinitis (AR), highlighting its underlying mechanisms phenotypes, potential regulatory roles eosinophils ILC2s. Eosinophils ILC2s regulate inflammation through lipid mediators, particularly cysteinyl leukotrienes (CysLTs) prostaglandins (PGs). Arachidonic acid (AA)-derived metabolites Sphinosine-1-phosphate (S1P) are significant markers that indicate immune dysfunction barrier Notably, promoters symptoms exhibit greater plasticity compared ILC2s, directly involved promoting symptoms. Our findings suggest metabolomic analysis provides insights into complex interactions between cells, environmental factors. Potential therapeutic targets have been highlighted further understand Future research metabolomics facilitate development novel diagnostics therapeutics for future application.
Language: Английский
Citations
4
Environmental Pollution, Journal Year: 2025, Volume and Issue: 367, P. 125642 - 125642
Published: Jan. 5, 2025
Language: Английский
Citations
0
Parodontologiya, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Relevance. Periodontitis and gingivitis are a significant concern in modern dentistry due to the persistently high global prevalence of periodontitis. This study aims review systematize current scientific knowledge regarding role increased epithelial permeability gingival sulcus pathogenesis these diseases. It also explores key aspects interaction between oral microbiota barrier. Materials Methods. A systematic analysis articles original research was conducted using PubMed, Google Scholar, eLIBRARY databases. From an initial pool 1,536 publications spanning 2004 2024, 53 were selected, comprising vivo vitro studies as well articles. The findings from summarized this review. Results. Emerging evidence indicates that disturbances mucosal can modulate both innate adaptive immune responses. Beneficial bacteria may trigger antimicrobial defense mechanisms through host responses or directly counteract periodontopathogens compromise Epithelialmesenchymal transition (EMT) is critical mechanism which cells lose their characteristic properties, altering phenotype. These changes result basement membrane degradation loss barrier integrity, ultimately contributing periodontal pocket formation infiltration pathogenic microorganisms into tissues. Intercellular junctions, particularly tight vital for maintaining stability functionality cells, playing crucial processes. Conclusion. Impairment barrier, permeability, facilitates microbial pathogens lead dysbiosis, exacerbating damage progression When evaluating sulcus, it essential consider factors such presence periodontopathogens, metabolites, expression junction proteins, genetic predispositions.
Language: Английский
Citations
0
RECIMA21 - Revista Científica Multidisciplinar - ISSN 2675-6218, Journal Year: 2025, Volume and Issue: 6(2), P. e626191 - e626191
Published: Feb. 14, 2025
O manuseio de substâncias químicas perigosas em ambientes trabalho apresenta riscos significativos à saúde e segurança ocupacional, incluindo intoxicações, explosões doenças graves. Esses afetam desde grandes indústrias até setores como laboratórios serviços saúde. A exposição está associada a altas taxas mortalidade relacionadas ao trabalho, destacando necessidade estratégias eficazes para mitigação riscos. Revisar aprimorar tecnologias, normativas boas práticas é crucial promover mais seguros sustentáveis. Dados levantados na literatura utilizando as plataformas PubMed, Scopus, SciELO Google Scholar foram utilizadas levantamento dados dessa narrativa. Substâncias representam ocupacionais indústria química, fábricas, agricultura, podendo causar respiratórias neoplasias. Normativas nacionais internacionais orientam medidas segurança, o uso obrigatório Equipamentos Proteção Individual (EPIs) Coletiva (EPCs), essenciais minimizar exposição. Essas visam proteger dos trabalhadores prevenir acidentes com produtos químicos perigosos. no têm avançado regulamentações rigorosas tecnologias emergentes, que ajudam reduzir mortes. Inovações monitoramento tempo real aumentam proteção, mas demandam treinamento especializado gestão riscos, cibersegurança. Além disso, os impactos das mudanças climáticas da poluição reforçam urgência políticas públicas educação contínua, garantir
Citations
0
Advances in Dermatology and Allergology, Journal Year: 2025, Volume and Issue: 42(1), P. 105 - 109
Published: Jan. 1, 2025
An impaired skin barrier has been reported in allergic diseases. In this study, we aimed to evaluate dermis thickness children with house dust allergy without symptoms. This cross-sectional study included aged 4-18 years asthma and/or rhinitis. Participants were divided into three groups: healthy controls (n = 50), patients sensitized mites 60), and negative mite tests 48). The of the layers was measured at cubital fossa using an ultrasound. median age gender distribution similar across mite-positive -negative groups control group. There no significant difference between terms (p 0.053). Absolute eosinophils eosinophil percentage significantly negatively correlated < 0.05). correlation total IgE, specific IgE test values > findings highlight impact sensitization on thickness, offering potential contributions management treatment strategies
Language: Английский
Citations
0
World Allergy Organization Journal, Journal Year: 2025, Volume and Issue: 18(3), P. 101036 - 101036
Published: March 1, 2025
Language: Английский
Citations
0