SARS-CoV-2 pathogenesis

Nature Reviews Microbiology, Journal Year: 2022, Volume and Issue: 20(5), P. 270 - 284

Published: March 30, 2022

Language: Английский

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An integrated cell atlas of the lung in health and disease

Nature Medicine, Journal Year: 2023, Volume and Issue: 29(6), P. 1563 - 1577

Published: June 1, 2023

Single-cell technologies have transformed our understanding of human tissues. Yet, studies typically capture only a limited number donors and disagree on cell type definitions. Integrating many single-cell datasets can address these limitations individual the variability present in population. Here we integrated Human Lung Cell Atlas (HLCA), combining 49 respiratory system into single atlas spanning over 2.4 million cells from 486 individuals. The HLCA presents consensus re-annotation with matching marker genes, including annotations rare previously undescribed types. Leveraging diversity individuals HLCA, identify gene modules that are associated demographic covariates such as age, sex body mass index, well changing expression along proximal-to-distal axis bronchial tree. Mapping new data to enables rapid annotation interpretation. Using reference for study disease, shared states across multiple lung diseases, SPP1

Language: Английский

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Biology of lung macrophages in health and disease

Immunity, Journal Year: 2022, Volume and Issue: 55(9), P. 1564 - 1580

Published: Sept. 1, 2022

Language: Английский

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The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19

Cell Reports Medicine, Journal Year: 2022, Volume and Issue: 3(6), P. 100663 - 100663

Published: June 1, 2022

Language: Английский

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Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner

Cell Reports, Journal Year: 2023, Volume and Issue: 42(2), P. 112131 - 112131

Published: Feb. 1, 2023

Fibrosis represents the common end stage of chronic organ injury independent initial insult, destroying tissue architecture and driving failure. Here we discover a population profibrotic macrophages marked by expression Spp1, Fn1, Arg1 (termed Spp1 macrophages), which expands after injury. Using an unbiased approach, identify chemokine (C-X-C motif) ligand 4 (CXCL4) to be among top upregulated genes during macrophage differentiation. In vitro in vivo studies show that loss Cxcl4 abrogates differentiation ameliorates fibrosis both heart kidney Moreover, find platelets, most abundant source CXCL4 vivo, drive Single nuclear RNA sequencing with ligand-receptor interaction analysis reveals orchestrate fibroblast activation via Sema3 crosstalk. Finally, confirm expand human disease

Language: Английский

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Recent advances in regenerative biomaterials

Regenerative Biomaterials, Journal Year: 2022, Volume and Issue: 9

Published: Jan. 1, 2022

Nowadays, biomaterials have evolved from the inert supports or functional substitutes to bioactive materials able trigger promote regenerative potential of tissues. The interdisciplinary progress has broadened definition 'biomaterials', and a typical new insight is concept tissue induction biomaterials. term 'regenerative biomaterials' thus contents this article are relevant yet beyond This review summarizes recent medical including metals, ceramics, hydrogels, other polymers bio-derived materials. As application aspects concerned, introduces for bone cartilage regeneration, cardiovascular repair, 3D bioprinting, wound healing cosmetology. Cell-biomaterial interactions highlighted. Since global pandemic coronavirus disease 2019, particularly mentions public health emergency. In last section, perspectives suggested: (i) creation source innovation; (ii) modification existing an effective strategy performance improvement; (iii) biomaterial degradation regeneration required be harmonious with each other; (iv) host responses can significantly influence clinical outcomes; (v) long-term outcomes should paid more attention to; (vi) noninvasive approaches monitoring

Language: Английский

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Inhibition of ferroptosis and iron accumulation alleviates pulmonary fibrosis in a bleomycin model

Redox Biology, Journal Year: 2022, Volume and Issue: 57, P. 102509 - 102509

Published: Oct. 18, 2022

Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease characterized by excessive proliferation of fibroblasts and accumulation extracellular matrix (ECM). Ferroptosis novel form cell death the lethal iron lipid peroxidation, which associated with many diseases. Our study addressed potential role played ferroptosis in progression fibrosis. We found that inducers injury, namely, bleomycin (BLM) lipopolysaccharide (LPS), induced lung epithelial cells. Both inhibitor liproxstatin-1 (Lip-1) chelator deferoxamine (DFO) alleviated symptoms or LPS. TGF-β stimulation upregulated expression transferrin receptor protein 1 (TFRC) human fibroblast line (MRC-5) mouse primary fibroblasts, resulting increased intracellular Fe2+, promoted transformation into myofibroblasts. Mechanistically, enhanced nuclear localization transcriptional coactivator tafazzin (TAZ), combined transcription factor TEA domain (TEAD)-4 to promote TFRC. In addition, elevated Fe2+ failed induce might be related regulation export metabolism. Finally, we specifically knocked out TFRC mice, compared those control were reduced knockout mice after induction. Collectively, these findings suggest therapeutic inhibitors chelators treating

Language: Английский

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Immune response in COVID-19: what is next?

Cell Death and Differentiation, Journal Year: 2022, Volume and Issue: 29(6), P. 1107 - 1122

Published: May 17, 2022

Abstract The coronavirus disease 2019 (COVID-19) has been a global pandemic for more than 2 years and it still impacts our daily lifestyle quality in unprecedented ways. A better understanding of immunity its regulation response to SARS-CoV-2 infection is urgently needed. Based on the current literature, we review here various virus mutations evolving manifestations along with alterations immune responses specific focuses innate response, neutrophil extracellular traps, humoral immunity, cellular immunity. Different types vaccines were compared analyzed based their unique properties elicit Various therapeutic strategies such as antibody, anti-viral medications inflammation control discussed. We predict that available continuously emerging new technologies, powerful administration schedules, effective public health measures, COVID-19 will be under near future.

Language: Английский

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Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19

Nature, Journal Year: 2022, Volume and Issue: 609(7928), P. 801 - 807

Published: July 28, 2022

Language: Английский

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Integrated single-cell analysis-based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis

Cardiovascular Research, Journal Year: 2022, Volume and Issue: 119(8), P. 1676 - 1689

Published: Oct. 3, 2022

Accumulation of mononuclear phagocytes [monocytes, macrophages, and dendritic cells (DCs)] in the vessel wall is a hallmark atherosclerosis. Using integrated single-cell analysis mouse human atherosclerosis, we here aimed to refine nomenclature atherosclerotic vessels compare their transcriptomic profiles disease.

Language: Английский

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