Defining the risk of SARS-CoV-2 variants on immune protection

Nature, Journal Year: 2022, Volume and Issue: 605(7911), P. 640 - 652

Published: March 31, 2022

Language: Английский

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Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

Nature Medicine, Journal Year: 2022, Volume and Issue: 29(1), P. 247 - 257

Published: Oct. 20, 2022

Language: Английский

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Heterologous immunization with inactivated vaccine followed by mRNA-booster elicits strong immunity against SARS-CoV-2 Omicron variant

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: May 13, 2022

The recent emergence of the Omicron variant has raised concerns on vaccine efficacy and urgent need to study more efficient vaccination strategies. Here we observed that an mRNA booster in individuals vaccinated with two doses inactivated significantly increased plasma level specific antibodies bind receptor-binding domain (RBD) or spike (S) ectodomain (S1 + S2) both G614 variants, compared homologous vaccine. RBD- S-specific IgG virus neutralization titers against variants concern heterologous group were similar receiving three mRNA-vaccine a boost after infection, but markedly higher than This regime furthermore enhanced RBD-specific memory B cell response S1-specific T response, Our demonstrates vaccines can be highly beneficial, as it increases humoral cellular immune responses virus, including variant.

Language: Английский

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Durability of BNT162b2 vaccine against hospital and emergency department admissions due to the omicron and delta variants in a large health system in the USA: a test-negative case–control study

The Lancet Respiratory Medicine, Journal Year: 2022, Volume and Issue: 10(7), P. 689 - 699

Published: April 22, 2022

Language: Английский

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The outbreak of SARS‐CoV‐2 Omicron lineages, immune escape, and vaccine effectivity

Journal of Medical Virology, Journal Year: 2022, Volume and Issue: 95(1)

Published: Sept. 13, 2022

As of November 2021, several SARS-CoV-2 variants appeared and became dominant epidemic strains in many countries, including five concern (VOCs) Alpha, Beta, Gamma, Delta, Omicron defined by the World Health Organization during COVID-19 pandemic. August 2022, is classified into main lineages, BA.1, BA.2, BA.3, BA.4, BA.5 some sublineages (BA.1.1, BA.2.12.1, BA.2.11, BA.2.75, BA.4.6) (https://www.gisaid.org/). Compared to previous VOCs (Alpha, Delta), all lineages have most highly mutations spike protein, with 50 accumulated throughout genome. Early data indicated that BA.2 sublineage had higher infectivity more immune escape than early wild-type (WT) strain, VOCs, BA.1. Recently, global surveillance suggest a transmissibility BA.4/BA.5 BA.1.1 becoming strain countries globally.

Language: Английский

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