Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Feb. 16, 2024
The
nervous
and
immune
systems
are
the
primary
sensory
interfaces
of
body,
allowing
it
to
recognize,
process,
respond
various
stimuli
from
both
external
internal
environment.
These
work
in
concert
through
mechanisms
neuro-immune
crosstalk
detect
threats,
provide
defense
against
pathogens,
maintain
or
restore
homeostasis,
but
can
also
contribute
development
diseases.
Among
peripheral
neurons
(PSNs),
nociceptive
PSNs
particular
interest.
They
possess
a
remarkable
capability
noxious
periphery
transmit
this
information
brain,
resulting
perception
pain
activation
adaptive
responses.
Pain
is
an
early
symptom
cancer,
often
leading
its
diagnosis,
major
source
distress
for
patients
as
disease
progresses.
In
review,
we
aim
overview
within
tumors
that
likely
induce
cancer
pain,
exploring
range
factors
etiological
elements
cellular
molecular
mediators.
addition
transmitting
central
system,
capable,
when
activated,
produce
release
neuropeptides
(e.g.,
CGRP
SP)
their
terminals.
have
been
shown
modulate
immunity
cases
inflammation,
infection,
cancer.
PSNs,
found
solid
tumors,
play
significant
role
tumor
microenvironment,
potentially
influencing
growth
anti-tumor
discuss
current
state
knowledge
about
degree
innervation
tumors.
We
seek
understand
whether
how
may
influence
associated
different
mouse
models
Finally,
extent
which
able
functions
innervate
it.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(2), P. 717 - 717
Published: Jan. 5, 2024
Y-box
binding
protein
1
(YBX1),
a
member
of
the
Cold
Shock
Domain
family,
is
overexpressed
in
various
human
cancers
and
recognized
as
an
oncogenic
gene
associated
with
poor
prognosis.
YBX1’s
functional
diversity
arises
from
its
capacity
to
interact
broad
range
DNA
RNA
molecules,
implicating
involvement
diverse
cellular
processes.
Independent
investigations
have
unveiled
specific
facets
contribution
cancer
development.
This
comprehensive
review
elucidates
multifaceted
role
across
hallmarks,
both
cell
itself
tumor
microenvironment.
Based
on
this,
we
proposed
YBX1
potential
target
for
treatment.
Notably,
ongoing
clinical
trials
addressing
breast
lung
showcased
promise
therapy.
The
ramp
up
vitro
research
targeting
compounds
also
underscores
growing
appeal.
Moreover,
emerging
neural
input
where
high
level
was
strongly
nerve
neurodegenerative
diseases.
summarized
up-to-date
advanced
pancreatic
cancer.
British Journal of Cancer,
Journal Year:
2024,
Volume and Issue:
130(9), P. 1415 - 1419
Published: Feb. 29, 2024
Abstract
Background
Multi-faceted
evidence
from
a
range
of
cancers
suggests
strongly
that
de
novo
expression
voltage-gated
sodium
channels
(VGSCs)
plays
significant
role
in
driving
cancer
cell
invasiveness.
Under
hypoxic
conditions,
common
to
growing
tumours,
VGSCs
develop
persistent
current
(I
NaP
)
which
can
be
blocked
selectively
by
ranolazine.
Methods
Several
different
carcinomas
were
examined.
We
used
data
experimental
approaches
relating
cellular
invasiveness
and
metastasis.
These
supplemented
survival
mined
patients.
Results
In
vitro,
ranolazine
inhibited
cells
especially
under
hypoxia.
vivo,
suppressed
the
metastatic
abilities
breast
prostate
melanoma.
supported
major
retrospective
epidemiological
study
on
breast,
colon
This
showed
risk
dying
was
reduced
ca.60%
among
those
taking
ranolazine,
even
if
this
started
4
years
after
diagnosis.
Ranolazine
also
shown
reduce
adverse
effects
chemotherapy
heart
brain.
Furthermore,
its
anti-cancer
effectiveness
could
boosted
co-administration
with
other
drugs.
Conclusions
Ranolazine,
alone
or
combination
appropriate
therapies,
reformulated
as
safe
anti-metastatic
drug
offering
many
potential
advantages
over
systemic
treatment
modalities.
BMC Cancer,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: Jan. 15, 2024
Glioblastoma
is
the
most
common
and
aggressive
malignant
primary
brain
tumor
in
adults.
cells
synthesize
secrete
large
quantities
of
excitatory
neurotransmitter
glutamate,
driving
epilepsy,
neuronal
death,
growth
invasion.
Moreover,
networks
interconnect
with
glioblastoma
cell
through
glutamatergic
neuroglial
synapses,
activation
which
induces
oncogenic
calcium
oscillations
that
are
propagated
via
gap
junctions
between
cells.
The
objective
this
study
to
explore
efficacy
brain-penetrating
anti-glutamatergic
drugs
standard
chemoradiotherapy
patients
glioblastoma.
Cell Research,
Journal Year:
2024,
Volume and Issue:
34(5), P. 345 - 354
Published: March 11, 2024
Abstract
Neural
signals
can
significantly
influence
cancer
prognosis.
However,
how
cells
may
proactively
modulate
the
nervous
system
to
benefit
their
own
survival
is
incompletely
understood.
In
this
study,
we
report
an
overlapping
pattern
of
brain
responses,
including
that
in
paraventricular
nucleus
hypothalamus,
multiple
mouse
models
peripheral
cancers.
A
multi-omic
screening
then
identifies
leukemia
inhibitory
factor
(LIF)
and
galectin-3
(Gal3)
as
key
cytokines
released
by
these
cell
types
trigger
activation.
Importantly,
increased
plasma
levels
two
are
observed
patients
with
different
We
further
demonstrate
pharmacologic
or
genetic
blockage
cell-derived
LIF
Gal3
signaling
abolishes
responses
strongly
inhibits
tumor
growth.
addition,
ablation
sympathetic
actions
similarly
restore
antitumor
immunity.
These
results
have
elucidated
a
novel,
shared
mechanism
hijacking
promote
progression.
Cell,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
Glioblastomas
are
invasive
brain
tumors
with
high
therapeutic
resistance.
Neuron-to-glioma
synapses
have
been
shown
to
promote
glioblastoma
progression.
However,
a
characterization
of
tumor-connected
neurons
has
hampered
by
lack
technologies.
Here,
we
adapted
retrograde
tracing
using
rabies
viruses
investigate
and
manipulate
neuron-tumor
networks.
Glioblastoma
rapidly
integrated
into
neural
circuits
across
the
brain,
engaging
in
widespread
functional
communication,
cholinergic
driving
invasion.
We
uncovered
patient-specific
tumor-cell-state-dependent
differences
synaptogenic
gene
expression
associated
connectivity
subsequent
invasiveness.
Importantly,
radiotherapy
enhanced
increased
neuronal
activity.
In
turn,
simultaneous
activity
inhibition
showed
effects,
indicative
role
for
neuron-to-glioma
contributing
Lastly,
rabies-mediated
genetic
ablation
halted
progression,
offering
viral
strategy
tackle
glioblastoma.
Together,
this
study
provides
framework
comprehensively
characterize
networks
target
