Seminars in Cell and Developmental Biology,
Journal Year:
2025,
Volume and Issue:
171, P. 103613 - 103613
Published: May 1, 2025
The
complex
interplay
between
the
immune
and
cardiovascular
systems
during
development,
homeostasis
regeneration
represents
a
rapidly
evolving
field
in
cardiac
biology.
Single
cell
technologies,
spatial
mapping
computational
analysis
have
revolutionised
our
understanding
of
diversity
functional
specialisation
cells
within
heart.
From
earliest
stages
cardiogenesis,
where
primitive
macrophages
guide
heart
tube
formation,
to
choreography
inflammation
its
resolution
regeneration,
emerge
as
central
orchestrators
fate.
Translating
these
fundamental
insights
into
clinical
applications
major
challenge
opportunity
for
field.
In
this
Review,
we
decode
immunological
blueprint
development
transform
disease
treatment
unlock
regenerative
capacity
human
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Abstract
Macrophages
are
immune
cells
belonging
to
the
mononuclear
phagocyte
system.
They
play
crucial
roles
in
defense,
surveillance,
and
homeostasis.
This
review
systematically
discusses
types
of
hematopoietic
progenitors
that
give
rise
macrophages,
including
primitive
progenitors,
erythro-myeloid
stem
cells.
These
have
distinct
genetic
backgrounds
developmental
processes.
Accordingly,
macrophages
exhibit
complex
diverse
functions
body,
phagocytosis
clearance
cellular
debris,
antigen
presentation,
response,
regulation
inflammation
cytokine
production,
tissue
remodeling
repair,
multi-level
regulatory
signaling
pathways/crosstalk
involved
homeostasis
physiology.
Besides,
tumor-associated
a
key
component
TME,
exhibiting
both
anti-tumor
pro-tumor
properties.
Furthermore,
functional
status
is
closely
linked
development
various
diseases,
cancer,
autoimmune
disorders,
cardiovascular
disease,
neurodegenerative
metabolic
conditions,
trauma.
Targeting
has
emerged
as
promising
therapeutic
strategy
these
contexts.
Clinical
trials
macrophage-based
targeted
drugs,
immunotherapies,
nanoparticle-based
therapy
were
comprehensively
summarized.
Potential
challenges
future
directions
targeting
also
been
discussed.
Overall,
our
highlights
significance
this
versatile
cell
human
health
which
expected
inform
research
clinical
practice.
Nature,
Journal Year:
2024,
Volume and Issue:
635(8039), P. 679 - 689
Published: Oct. 16, 2024
Human
prenatal
skin
is
populated
by
innate
immune
cells,
including
macrophages,
but
whether
they
act
solely
in
immunity
or
have
additional
functions
morphogenesis
unclear.
Here
we
assembled
a
comprehensive
multi-omics
reference
atlas
of
human
(7-17
post-conception
weeks),
combining
single-cell
and
spatial
transcriptomics
data,
to
characterize
the
microanatomical
tissue
niches
skin.
This
revealed
that
crosstalk
between
non-immune
cells
underpins
formation
hair
follicles,
implicated
scarless
wound
healing
crucial
for
angiogenesis.
We
systematically
compared
hair-bearing
organoid
(SkO)
model
derived
from
embryonic
stem
induced
pluripotent
adult
Trends in Endocrinology and Metabolism,
Journal Year:
2024,
Volume and Issue:
35(11), P. 981 - 995
Published: May 4, 2024
Lipid-associated
macrophages
(LAMs)
are
phagocytic
cells
with
lipid-handling
capacity
identified
in
various
metabolic
derangements.
During
disease
development,
they
locate
to
atherosclerotic
plaques,
adipose
tissue
(AT)
of
individuals
obesity,
liver
lesions
steatosis
and
steatohepatitis,
the
intestinal
lamina
propria.
LAMs
can
also
emerge
metabolically
demanding
microenvironment
certain
tumors.
In
this
review,
we
discuss
major
questions
regarding
LAM
recruitment,
differentiation,
self-renewal,
and,
ultimately,
their
acute
chronic
functional
impact
on
development
diseases.
Further
studies
need
clarify
whether
under
which
circumstances
drive
progression
or
resolution
how
phenotype
be
modulated
ameliorate
disorders.
Journal of Advanced Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Cancer
immunotherapy
has
emerged
as
a
groundbreaking
approach
in
cancer
treatment,
primarily
realized
through
the
manipulation
of
immune
cells,
notably
T
cell
adoption
and
checkpoint
blockade.
Nevertheless,
cells
encounters
formidable
hurdles.
Macrophages,
serving
pivotal
link
between
innate
adaptive
immunity,
play
crucial
roles
phagocytosis,
cytokine
secretion,
antigen
presentation.
Consequently,
macrophage-targeted
therapies
have
garnered
significant
attention.
We
aim
to
provide
most
cutting-edge
insights
future
perspectives
for
therapies,
fostering
development
novel
effective
treatments.
To
date,
forefront
strategies
macrophage
targeting
encompass:
altering
their
plasticity,
harnessing
CAR-macrophages,
phagocytosis
checkpoints.
Macrophages
are
characterized
by
remarkable
diversity
offering
unique
therapeutic
target.
In
this
context,
we
critically
analyze
innovative
aimed
at
transforming
macrophages
from
M2
(tumor-promoting)
M1
(tumor-suppressing)
phenotype.
Furthermore,
delve
into
design
principles,
developmental
progress,
advantages
CAR-macrophages.
Additionally,
illuminate
challenges
encountered
checkpoints
on
propose
potential
overcome
these
obstacles.
Journal of Cellular and Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
28(13)
Published: July 1, 2024
Abstract
Triple‐negative
breast
cancer
(TNBC)
is
often
considered
one
of
the
most
aggressive
subtypes
cancer,
characterized
by
a
high
recurrence
rate
and
low
overall
survival
(OS).
It
notorious
for
posing
challenges
related
to
drug
resistance.
While
there
has
been
progress
in
TNBC
research,
mechanisms
underlying
chemotherapy
resistance
remain
largely
elusive.
We
collect
single‐cell
RNA
sequencing
(scRNA‐seq)
data
from
five
patients
susceptible
resistant
cases.
Comprehensive
analyses
involving
copy
number
variation
(CNV),
pseudotime
trajectory,
cell–cell
interactions,
pseudospace
analysis,
as
well
transcription
factor
functional
enrichment
are
conducted
specifically
on
macrophages
malignant
cells.
Furthermore,
we
performed
validation
experiments
clinical
samples
using
multiplex
immunofluorescence.
identified
subset
SPP1
+
that
secrete
signals
interacting
with
CD44
cell
surfaces,
potentially
activating
PDE3B
pathway
within
cells
via
integrin
pathway,
leading
The
abnormally
enhanced
signal
between
may
serve
promoting
patients.
Therefore,
could
therapeutic
target
reduce
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2024,
Volume and Issue:
14
Published: Oct. 9, 2024
Macrophages
play
a
pivotal
role
in
the
innate
immune
response.
While
their
most
characteristic
function
is
phagocytosis,
it
important
not
to
solely
characterize
macrophages
by
this
activity.
Their
crucial
roles
body
development,
homeostasis,
repair,
and
responses
against
pathogens
necessitate
broader
understanding.
exhibit
remarkable
plasticity,
allowing
them
modify
functional
characteristics
response
tissue
microenvironment
(tissue
type,
presence
of
or
inflammation,
specific
signals
from
neighboring
cells)
swiftly.
there
no
single
defined
"macrophage"
entity,
diverse
array
macrophage
types
because
ontogeny
involves
differentiation
progenitor
cells
into
tissue-resident
macrophages,
as
well
recruitment
circulating
monocytes
tissue-specific
cues.
In
addition,
continuously
sense
respond
environmental
cues
conditions,
adjusting
metabolic
states
accordingly.
Consequently,
paramount
importance
comprehend
heterogeneous
origins
functions
employed
Annual Review of Genomics and Human Genetics,
Journal Year:
2024,
Volume and Issue:
25(1), P. 353 - 367
Published: Feb. 16, 2024
RNA
sequencing
(RNA-seq)
enables
the
accurate
measurement
of
multiple
transcriptomic
phenotypes
for
modeling
impacts
disease
variants.
Advances
in
technologies,
experimental
protocols,
and
analysis
strategies
are
rapidly
expanding
application
RNA-seq
to
identify
biomarkers,
tissue-
cell-type-specific
impacts,
spatial
localization
disease-associated
mechanisms.
Ongoing
international
efforts
construct
biobank-scale
repositories
with
matched
genomic
data
across
diverse
population
groups
further
increasing
utility
approaches
by
providing
large-scale
normative
reference
resources.
The
availability
these
resources,
combined
improved
computational
pipelines,
has
enabled
detection
aberrant
underlying
rare
diseases.
Further
expansion
both
somatic
developmental
tissues,
is
expected
soon
provide
unprecedented
insights
resolve
origin,
mechanism
action,
causal
gene
contributions,
suggesting
continued
high
diagnosis.
