Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors DOI Creative Commons

Conor J. McClune,

Chun‐Ting Liu, Chloe Wick

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use the clinic. A prominent example is anti-cancer paclitaxel (Taxol

Language: Английский

Multiplexed perturbation of yew reveals cryptic proteins that enable a total biosynthesis of baccatin III and Taxol precursors DOI Creative Commons

Conor J. McClune,

Chun‐Ting Liu, Chloe Wick

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Plants make complex and potent therapeutic molecules, but difficulties in sourcing from natural producers or chemical synthesis can challenge their use the clinic. A prominent example is anti-cancer paclitaxel (Taxol

Language: Английский

Citations

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