BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 17, 2024
Language: Английский
Biologics, Journal Year: 2024, Volume and Issue: Volume 18, P. 229 - 255
Published: Sept. 1, 2024
Natural products have proven to be promising anti-cancer agents due their diverse chemical structures and bioactivity.This review examines central role in cancer treatment, focusing on mechanisms of action therapeutic benefits.Medicinal plants contain bioactive compounds, such as flavonoids, alkaloids, terpenoids polyphenols, which exhibit various anticancer properties.These compounds induce apoptosis, inhibit cell proliferation cycle progression, interfere with microtubule formation, act topoisomerase targets, angiogenesis, modulate key signaling pathways, improve the tumor microenvironment, reverse drug resistance activate immune cells.Herbal drugs offer advantages, particularly selective toxicity against cells, reducing adverse side effects associated conventional chemotherapy.Recent studies clinical trials highlight benefits herbal medicines alleviating effects, improving tolerance chemotherapy occurrence synergistic treatments.For example, medicine SH003 was found safe potentially effective treatment solid cancers, while Fucoidan showed anti-inflammatory properties that are beneficial for patients advanced cancer.The current research landscape is extensive.Numerous investigating efficacy, safety cancers lung, prostate, breast hepatocellular carcinoma.Promising developments include polypharmacological approach, combination therapies, immunomodulation improvement quality life.However, there still challenges development use natural drugs, need further into action, possible interactions optimal dosage.Standardizing extracts, bioavailability delivery, overcoming regulatory acceptance hurdles critical issues addressed.Nonetheless, warrant investigation development.Multidisciplinary collaboration essential advance therapy integrate these mainstream treatment.
Language: Английский
Citations
16
Biomedicines, Journal Year: 2024, Volume and Issue: 12(2), P. 418 - 418
Published: Feb. 11, 2024
Epithelial-mesenchymal transition (EMT) is a crucial and fundamental mechanism in many cellular processes, beginning with embryogenesis via tissue remodulation wound healing, plays vital role tumorigenesis metastasis formation. EMT complex process that involves transcription factors genes enable the tumor cell to leave primary location, invade basement membrane, send other tissues. Moreover, it may help avoid immune system establish radioresistance chemoresistance. It also change normal microenvironment, thus promoting key for survival, such as hypoxia-induced factor-1 (HIF-1) neoangiogenesis. In this review, we will focus mainly on of benign prostate disease especially establishment malignant tumors, their invasiveness, aggressive behavior. We discuss relevant study methods evaluation possible clinical implications. introduce trials conducted according CONSORT 2010 try harness properties form circulating cells predict patterns cancer. This review provide most up-to-date information keen understanding microenvironmental processes developing novel treatment lines by modifying or blocking pathways.
Language: Английский
Citations
11
Heca Journal of Applied Sciences, Journal Year: 2025, Volume and Issue: 3(1), P. 30 - 55
Published: March 19, 2025
Prostate cancer remains a major contributor to cancer-related deaths in men, with its incidence rising significantly age. Conventional treatment modalities, including surgery, radiation therapy, hormonal and chemotherapy, often face limitations such as resistance, disease recurrence, considerable side effects. These challenges have sparked growing interest novel approaches like immunotherapy, which leverages the immune system combat cancer. Among these, vaccine-based immunotherapy has emerged promising strategy, aiming generate precise responses against tumor-specific antigens. Advances immunology, molecular targeting, vaccine development demonstrated encouraging results terms of safety immunogenicity. Nevertheless, obstacles tumor heterogeneity, escape mechanisms, limited efficacy advanced stages continue hinder progress. The aim this review is examine current landscape prostate development, focus on advancements target identification, optimization technologies, evaluation combination therapy strategies. Findings from clinical trials shed light both opportunities therapies. Synergistic involving checkpoint inhibitors, radiotherapy, androgen deprivation shown potential amplify mitigate resistance mechanisms. Additionally, emerging technologies bioinformatics artificial intelligence are revolutionizing by enabling discovery patient-specific neoantigens creation tailored formulations. Despite these breakthroughs, achieving consistent therapeutic outcomes challenging, particularly metastatic castration-resistant cases. Future directions field include developing personalized vaccines, adopting adaptive trial designs, employing innovative endpoints streamline translation into practice. In summary, while significantly, addressing critical barriers heterogeneity evasion embracing essential for optimizing vaccines improving outcomes.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 5, 2024
The occurrence of ovarian cancer (OC) is a major factor in women’s mortality rates. Despite progress medical treatments, like new drugs targeting homologous recombination deficiency, survival rates for OC patients are still not ideal. tumor microenvironment (TME) includes cells, fibroblasts linked to (CAFs), immune-inflammatory and the substances these cells secrete, along with non-cellular components extracellular matrix (ECM). First, TME mainly plays role inhibiting growth protecting normal cell survival. As tumors progress, gradually becomes place promote progression. Immune have attracted much attention as targets immunotherapy. checkpoint inhibitor (ICI) therapy has potential regulate TME, suppressing factors that facilitate advancement, reactivating immune managing growth, extending advanced cancer. This review presents an outline current studies on distinct cellular elements within detailing their main functions possible signaling pathways. Additionally, we examine immunotherapy rechallenge OC, specific emphasis biological reasons behind resistance ICIs.
Language: Английский
Citations
3
Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(8)
Published: Nov. 9, 2024
Hepatocellular carcinoma (HCC) continues to pose a global health concern, necessitating the exploration of innovative therapeutic approaches. In recent decade, targeting tumor stroma consisting extracellular matrix (ECM), immune cells, vascular system, hypoxia, and also suppressive mechanisms in HCC has attracted interest repressing growth metastasis. Phytochemicals have attained considerable attention because their manifold biological effects high capacity for anticancer activities. These chemical agents shown capability modulate different cells secretions within malignancies. years, development nanoformulations further enhanced potential phytochemicals by improving solubility, bioavailability, targeted delivery tissues. This review aims provide an encyclopedic overview as promising strategies HCC. The initially highlights broad array exhibiting potent properties, including flavonoids, alkaloids, terpenoids, phenolic compounds, among others. Then, modification these will be reviewed. Finally, we latest experiments that examined modulation using adjuvant nanoformulations.
Language: Английский
Citations
3
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105938 - 105938
Published: July 4, 2024
Language: Английский
Citations
2
Veterinary World, Journal Year: 2024, Volume and Issue: unknown, P. 1655 - 1660
Published: July 1, 2024
Background and Aim: Aeromonas hydrophila infections in fish result significant financial losses within aquaculture. Previous research indicates black soldier fly (BSF) prepupae provide immunomodulatory benefits through their fatty acids, chitin, proteins. The study evaluated the impact of hexane extract from (HEBP) on interleukin (IL)-4 IL-10 cytokine expression zebrafish, both infected uninfected with A. hydrophila. Materials Methods: Adult zebrafish (aged 4–5 months) was assigned to a negative control group (fed commercial feed), positive (commercial feed + infection at 107 colony-forming unit/mL), three treatment groups (T1, T2, T3) that received HEBP doses 1000; 2000 4000 mg/kg for 30 days, respectively. introduced day 31 immersion. Analysis IL-4 head kidney trunk region (body without tail) quantitative polymerase chain reaction conducted 33. Results: modulated immune response concentration 1000 feed, as evidenced by an increase not bacteria. However, these cytokines were decreased groups. Conclusion: A identified optimal modulation. This discovery marks advancement development benefit natural extract-based immunomodulator model, which is potentially immunotherapeutic against bacterial aquaculture industry. Keywords: hydrophilia, larvae, extract, modulation, zebrafish.
Language: Английский
Citations
0
Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 295 - 315
Published: Oct. 24, 2024
Prostate cancer is one of the most common malignancies in men. The tumour microenvironment (TME) has a critical role initiation, progression, and metastasis prostate cancer. TME contains various cell types, including cancer-associated fibroblasts (CAFs), endothelial cells, immune cells such as macrophages, lymphocytes B T, natural killer (NK) other proteins extracellular matrix (ECM) components. interactions communications between these within are crucial for growth response solid tumours, to different anticancer modalities. In this review article, we exemplify mechanisms by which influences progression. roles cytokines, chemokines, factors modulating will be discussed. impact ECM components on invasion also We explain how can affect therapy. highlight importance understanding develop novel therapeutic approaches
Language: Английский
Citations
0
European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177149 - 177149
Published: Nov. 1, 2024
Language: Английский
Citations
0
International Reviews of Immunology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 24
Published: Nov. 29, 2024
Despite advancements in breast cancer treatment, therapeutic resistance, and tumor recurrence continue to pose formidable challenges. Therefore, a deep knowledge of the intricate interplay between immune system is necessary. In pursuit combating cancer, awakening antitumor immunity has been proposed as compelling avenue. Tumor stroma cancers contains multiple stromal cells that impact resistance therapy also expansion malignant cells. Activating or repressing these cells, well their secretions can be for exhausting mechanisms growth. NK T lymphocytes are prominent components triggered by adjuvants eradicating However, like endothelial fibroblast some suppressive consisting premature myeloid subsets macrophages CD4+ lymphocytes, dampen favor growth resistance. This review article aims research prospect harnessing power drugs, adjuvants, nanoparticles reactions against By investigating immunomodulatory properties pharmacological agents synergistic effects this seeks uncover through which triggered. Moreover, current delineates challenges opportunities translational journey from bench bedside.
Language: Английский
Citations
0