Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107526 - 107526
Published: Nov. 1, 2024
Language: Английский
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(7), P. 3103 - 3120
Published: June 18, 2024
With one of the highest mortality rates all malignancies, 5-year survival rate for esophageal cancer is under 20%. Depending on stage and extent disease, current standard care treatment paradigm includes chemotherapy or chemoradiotherapy followed by surgical esophagogastrectomy, with consideration adjuvant immunotherapy residual disease. This regimen has high morbidity, due to anatomic changes inherent in surgery, acuity complications, off-target effects systemic immunotherapy. We begin a review treatments, then discuss new emerging targets therapies advanced drug delivery systems. Recent ongoing preclinical early clinical studies are evaluating traditional tumor (e.g., human epidermal growth factor receptor 2), as well promising such Yes-associated protein 1 mammalian target rapamycin develop treatments this Due function location esophagus, opportunities also exist pair these strategy increase targeting, bioavailability, intratumor concentrations, two most common platforms being stents nanoparticles. Finally, results antibody conjugates chimeric antigenic T cells show promise upcoming therapies. discusses innovations therapeutics context their successes failures, goal identifying those solutions that demonstrate shift treating deadly
Language: Английский
Citations
4
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Spinal cord injury (SCI) represents a significant clinical challenge. Following SCI, the implementation of protective measures for neurons is critically important. Current applications hormone pulse therapy exhibit variable efficacy and considerable side effects, highlighting an urgent need therapeutic strategies. This study investigates pathological conditions ischemia hypoxia in SCI region, complemented by early transcriptome sequencing postinjury. Our findings suggest that targeting ferroptosis pivotal neuroprotection following SCI. Aiming at cascade effect mitochondrial damage leading to reactive oxygen species (ROS) production, along with extensive ROS-mediated lysosomal during signaling, we developed liposome-based system regulating iron metabolism─DTLS@CAT. innovative liposome designed specifically target neuronal mitochondria, effectively eliminate mitoROS, modulate complex interactions among metabolism, lysosomes, ROS facilitate recovery from
Language: Английский
Citations
0
Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1095 - 1095
Published: Feb. 27, 2025
Cancer remains a significant global public health challenge, with hepatocellular carcinoma (HCC) ranking among the top five malignancies in terms of mortality. Faberidilactone A, sesquiterpenoid dimer isolated from Inula japonica, exhibits potent cytotoxicity against various human tumor cell lines and demonstrates remarkable antitumor potential. In vitro studies using HepG2 cells revealed that faberidilactone A induces apoptosis ferroptosis, causes cycle arrest, enhances production intracellular reactive oxygen species (ROS), disrupts mitochondrial function. Mechanistic investigations via Western blot analysis indicated impedes proliferation by modulating signal transducer activator transcription 3 (STAT3) signaling pathway inhibits metastasis affecting focal adhesion kinase (FAK) pathway. vivo experiments zebrafish model demonstrated effectively suppresses dissemination anti-angiogenic properties. When concentration reached 10 µM, inhibition rates proliferation, migration, intersegmental vessels (ISVs) length were 76.9%, 72.6%, 46.2%, respectively. These findings underscore therapeutic potential as promising agent for HCC treatment.
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 8, 2024
Ferroptosis, distinct from apoptosis, necrosis, and autophagy, is a unique type of cell death driven by iron-dependent phospholipid peroxidation. Since ferroptosis was defined in 2012, it has received widespread attention researchers worldwide. From biochemical perspective, the regulation strongly associated with cellular metabolism, primarily including iron lipid redox metabolism. The distinctive regulatory mechanism holds great potential for overcoming drug resistance-a major challenge treating cancer. considerable role nanobiotechnology disease treatment been widely reported, but further more systematic discussion on how enhances therapeutic efficacy ferroptosis-associated diseases still needs to be improved. Moreover, while exciting cancer relatively well summarized, its applications other diseases, such as neurodegenerative cardiovascular cerebrovascular kidney disease, remain underreported. Consequently, necessary fill these gaps complete ferroptosis. In this review, we provide an extensive introduction background elaborate network. Subsequently, discuss various advantages combining enhance reduce side effects diseases. Finally, analyze feasibility improving clinical outcomes based needs, current limitations future directions ferroptosis, which will not only significant guidance also accelerate their translations.
Language: Английский
Citations
3
Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: unknown, P. 137479 - 137479
Published: March 1, 2025
Language: Английский
Citations
0
Chinese Journal of Natural Medicines, Journal Year: 2024, Volume and Issue: 22(12), P. 1177 - 1192
Published: Dec. 1, 2024
Language: Английский
Citations
2
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 9659 - 9688
Published: Sept. 1, 2024
Reactive oxygen species (ROS) encompass a diverse group of chemically reactive molecules or ions distinguished by their substantial oxidative potential. Empirical studies have shown that the targeted administration high toxic concentrations ROS can effectively induce tumor cell death in various types. Numerous bioactive ingredients derived from traditional Chinese medicine (TCM), recognized for ROS-inducing properties, demonstrated significant anti-tumor activity. Nonetheless, clinical application has been hindered challenges such as low solubility, limited bioavailability, and poor selectivity. Multifunctional nanoformulations possess potential to overcome these enhance anticancer efficacy active compounds. Through extensive searches academic databases thorough review screening relevant literature, this study aims systematically summarize generalize multiple TCM generation, along with multifunctional nanoformulations, perspectives. The objective is provide new insights references fundamental cancer research treatments. Furthermore, we acknowledge although numerous potentials, potentially offering novel strategies therapy, underlying mechanisms require further comprehensive investigation.
Language: Английский
Citations
1
PubMed, Journal Year: 2024, Volume and Issue: 44(7), P. 1389 - 1396
Published: July 20, 2024
To explore the role of ferroptosis-related genes in regulating ferroptosis esophageal squamous cell carcinoma (ESCC).
Language: Английский
Citations
0
Environmental Pollution, Journal Year: 2024, Volume and Issue: 363, P. 125271 - 125271
Published: Nov. 7, 2024
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107526 - 107526
Published: Nov. 1, 2024
Language: Английский
Citations
0