Cognitive Neurodynamics, Journal Year: 2021, Volume and Issue: 16(1), P. 17 - 41
Published: June 14, 2021
Language: Английский
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: Aug. 29, 2022
The mechanisms controlling dynamical patterns in spontaneous brain activity are poorly understood. Here, we provide evidence that cortical dynamics the ultra-slow frequency range (<0.01-0.1 Hz) requires intact cortical-subcortical communication. Using functional magnetic resonance imaging (fMRI) at rest, identify Dynamic Functional States (DFSs), transient but recurrent clusters of and subcortical regions synchronizing frequencies. We observe shifts temporally coincident with clusters, flexibly either limbic (hippocampus/amygdala), or nuclei (thalamus/basal ganglia). Focal lesions induced by stroke, especially those damaging white matter connections between basal ganglia/thalamus cortex, provoke anomalies fraction times, dwell transitions DFSs, causing a bias toward abnormal network integration. Dynamical observed 2 weeks after stroke recover time contribute to explaining neurological impairment long-term outcome.
Language: Английский
Citations
45
Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)
Published: June 27, 2022
Abstract The critical brain hypothesis states that biological neuronal networks, because of their structural and functional architecture, work near phase transitions for optimal response to internal external inputs. Criticality thus provides function behavioral capabilities. We test this by examining the influence injury (strokes) on criticality neural dynamics estimated at level single participants using directly measured individual connectomes whole-brain models. Lesions engender a sub-critical state recovers over time in parallel with behavior. improvement is associated re-modeling specific white-matter connections. show personalized dynamical models poised track dynamics, alteration post-stroke, behavior participants.
Language: Английский
Citations
43
Trends in Neurosciences, Journal Year: 2024, Volume and Issue: 47(4), P. 303 - 318
Published: Feb. 23, 2024
Stroke is a leading cause of adult disability. Understanding stroke damage and recovery requires deciphering changes in complex brain networks across different spatiotemporal scales. While recent developments readout technologies progress network modeling have revolutionized current understanding the effects on at macroscale, reorganization smaller scale remains incompletely understood. In this review, we use conceptual framework graph theory to define from nano- macroscales. Highlighting stroke-related connectivity studies multiple scales, argue that multiscale connectomics-based approaches may provide new routes better evaluate structural functional remapping after during recovery.
Language: Английский
Citations
10
Human Brain Mapping, Journal Year: 2025, Volume and Issue: 46(2)
Published: Jan. 27, 2025
Over a third of minor stroke patients experience post-stroke cognitive impairment (PSCI), but no validated tools exist to identify at-risk early. This study investigated whether disconnection features derived from infarcts and white matter hyperintensities (WMH) could serve as markers for short- long-term decline in first-ever ischemic patients. First-ever (NIHSS ≤ 7) were prospectively followed at 72-h, 6 months, 36 months with tests brain MRI. Infarct WMH volumes semi-automatically assessed on DWI FLAIR sequences. Bayesian tract-based models estimated remote pathological effects WMH. Associations between outcomes analyzed using canonical correlation analyses, adjusted age, education, multiple comparisons. Among 105 (31% female, mean age 63 ± 12 years), infarct volume averaged 10.28 17.10 cm3 predominantly involved the middle cerebral artery territory (83%). burden was higher frontal periventricular matter. Infarct-based did not significantly relate PCSI. However, WMH-derived factor, involving commissural tracts, right superior longitudinal fasciculus, associated PSCI (OR = 9.96, p value 0.02) 12.27, 0.006), particularly executive/attention, language, visuospatial domains. unrelated volume, outperformed demographic clinical predictors PSCI. WMH-induced may be stroke. Routine MR-derived rehabilitation trials.
Language: Английский
Citations
1
NeuroImage, Journal Year: 2020, Volume and Issue: 210, P. 116589 - 116589
Published: Jan. 30, 2020
Focal brain lesions disrupt resting-state functional connectivity, but the underlying structural mechanisms are unclear. Here, we examined direct and indirect effects of disconnections on connectivity in a large sample sub-acute stroke patients with heterogeneous lesions. We estimated impact each patient's lesion connectome by embedding diffusion MRI streamline tractography atlas constructed using data from healthy individuals. defined as loss connections between two regions, increases shortest path length regions that lack connections. then tested hypothesis disruptions would be more severe for disconnected than spared On average, nearly 20% all region pairs were to either directly or indirectly our sample, extensive associated primarily damage deep white matter locations. Importantly, both showed connections, respectively, although tended most sustained disconnections. Together, these results emphasize widespread impacts focal show reflected connectome. Further, they indicate addition disconnections, lesion-induced lengths structurally connected provide information about remote caused
Language: Английский
Citations
64
NeuroImage, Journal Year: 2021, Volume and Issue: 245, P. 118642 - 118642
Published: Oct. 12, 2021
Motor recovery following ischemic stroke is contingent on the ability of surviving brain networks to compensate for damaged tissue. In rodent models, sensory and motor cortical representations have been shown remap onto intact tissue around lesion site, but remapping more distal sites (e.g. in contralesional hemisphere) has also observed. Resting state functional connectivity (FC) analysis employed study compensatory network adaptations humans, mechanisms time course are not well understood. Here, we examine longitudinal FC 23 first-episode pontine patients utilize a graph matching approach identify patterns reorganization during recovery. We quantified between several intervals ranging from 1 week 6 months stroke, demonstrated that areas undergo most frequently cerebellar/subcortical networks. Brain regions with structural connectome disruption due had over time. Finally, show correlated extent early late subacute phases, furthermore, individuals greater baseline impairment demonstrate extensive (from one two weeks post-stroke) this correlates better at months. Taken together, these results suggest our can quantify recovery-relevant, whole-brain after stroke.
Language: Английский
Citations
49
Journal of Stroke, Journal Year: 2021, Volume and Issue: 23(3), P. 297 - 311
Published: Sept. 30, 2021
The neurological symptoms of stroke have traditionally provided the foundation for functional mapping brain. However, there are many unresolved aspects in our understanding cerebral activity, especially regarding high-level cognitive functions. This review provides a comprehensive look at pathophysiology post-stroke impairment light recent findings from advanced imaging techniques. Combining network neuroscience and clinical neurology, research focuses on how changes brain networks correlate with prognosis. More specifically, we first discuss general consequences lesions due to damage canonical resting-state large-scale or composition entire We also emerging methods, such as lesion-network gradient analysis, used study aforementioned events caused by lesions. Lastly, examine other patient vulnerabilities, superimposed amyloid pathology blood-brain barrier leakage, which potentially lead different outcomes compositions even presence similar knowledge will allow better provide theoretical basis development new treatments, neuromodulation.
Language: Английский
Citations
44
Biological Psychiatry, Journal Year: 2022, Volume and Issue: 92(12), P. 973 - 983
Published: May 18, 2022
Language: Английский
Citations
35
Brain Structure and Function, Journal Year: 2022, Volume and Issue: 227(9), P. 3173 - 3187
Published: July 26, 2022
Language: Английский
Citations
30
Brain Structure and Function, Journal Year: 2022, Volume and Issue: 227(9), P. 3129 - 3144
Published: Sept. 1, 2022
Language: Английский
Citations
29