Reduced emergent character of neural dynamics in patients with a disrupted connectome DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119926 - 119926

Published: Feb. 3, 2023

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification emergence for experimental data, neuroscientists have been unable empirically test this long-standing conjecture. Here we investigate fundamental question by leveraging recently proposed framework known as "Integrated Information Decomposition," which establishes principled information-theoretic approach operationalise quantify in dynamical systems - including human brain. By analysing functional MRI our results show that emergent hierarchical character dynamics is significantly diminished chronically unresponsive patients suffering severe injury. At level, demonstrate capacity positively correlated with extent organisation activity. Furthermore, combining computational approaches network control theory whole-brain biophysical modelling, reduced severely brain-injured can be mechanistically explained disruptions patients' structural connectome. Overall, suggest chronic unresponsiveness resulting injury may related impairment infrastructures required support emergence.

Language: Английский

It’s about time: Linking dynamical systems with human neuroimaging to understand the brain DOI Creative Commons
Yohan J. John, Kayle S. Sawyer, Karthik Srinivasan

et al.

Network Neuroscience, Journal Year: 2022, Volume and Issue: 6(4), P. 960 - 979

Published: Jan. 1, 2022

Abstract Most human neuroscience research to date has focused on statistical approaches that describe stationary patterns of localized neural activity or blood flow. While these are often interpreted in light dynamic, information-processing concepts, the static, local, and inferential nature approach makes it challenging directly link neuroimaging results plausible underlying mechanisms. Here, we argue dynamical systems theory provides crucial mechanistic framework for characterizing both brain’s time-varying quality its partial stability face perturbations, hence, this perspective can have a profound impact interpretation their relationship with behavior. After briefly reviewing some key terminology, identify three ways which analyses embrace perspective: by shifting from local more global perspective, focusing dynamics instead static snapshots activity, embracing modeling map using “forward” models. Through approach, envisage ample opportunities researchers enrich understanding dynamic mechanisms support wide array brain functions, health setting psychopathology.

Language: Английский

Citations

43
Multiple cortical visual streams in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(7), P. 3319 - 3349

Published: July 14, 2022

The effective connectivity between 55 visual cortical regions and 360 was measured in 171 HCP participants using the HCP-MMP atlas, complemented with functional diffusion tractography. A Ventrolateral Visual "What" Stream for object face recognition projects hierarchically to inferior temporal cortex, which orbitofrontal cortex reward value emotion, hippocampal memory system. Ventromedial "Where" scene representations connects parahippocampal gyrus hippocampus. An Inferior STS (superior sulcus) Semantic receives from Stream, parietal PGi, ventromedial-prefrontal system language systems. Dorsal via V2 V3A MT+ Complex (including MT MST), connect intraparietal LIP, VIP MIP) involved motion actions space. It performs coordinate transforms idiothetic update of representations. Superior inputs STV, auditory A5, is activated by expression, vocalization, important social behaviour,

Language: Английский

Citations

42
In vivo mapping of pharmacologically induced functional reorganization onto the human brain’s neurotransmitter landscape DOI Creative Commons
Andrea I. Luppi, Justine Y. Hansen, R. Adapa

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(24)

Published: June 14, 2023

To understand how pharmacological interventions can exert their powerful effects on brain function, we need to they engage the brain's rich neurotransmitter landscape. Here, bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating regional distribution of 19 receptors transporters obtained from positron emission tomography, changes in magnetic resonance imaging connectivity 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs' function multiple systems. The both anesthetics psychedelics are organized along hierarchical gradients structure function. Last, show that co-susceptibility recapitulates disorder-induced structural alterations. Collectively, these highlight statistical patterns drug-induced reorganization architecture.

Language: Английский

Citations

32
The non-specific matrix thalamus facilitates the cortical information processing modes relevant for conscious awareness DOI Creative Commons
Eli J. Műller, Brandon R. Munn, Michelle J. Redinbaugh

et al.

Cell Reports, Journal Year: 2023, Volume and Issue: 42(8), P. 112844 - 112844

Published: July 25, 2023

The neurobiological mechanisms of arousal and anesthesia remain poorly understood. Recent evidence highlights the key role interactions between cerebral cortex diffusely projecting matrix thalamic nuclei. Here, we interrogate these processes in a whole-brain corticothalamic neural mass model endowed with targeted thalamocortical nuclei inferred from empirical data. This captures features seen propofol anesthesia, including diminished network integration, lowered state diversity, impaired susceptibility to perturbation, decreased corticocortical coherence. Collectively, signatures reflect suppression information transfer across cortex. We recover conscious by selectively stimulating thalamus, recapitulating results macaque, as well wake-like processing states that modulation large-scale cortical attractor dynamics. Our highlight projections shaping many complex dynamics facilitate unique communication supporting awareness.

Language: Английский

Citations

32
Reduced emergent character of neural dynamics in patients with a disrupted connectome DOI Creative Commons
Andrea I. Luppi, Pedro A. M. Mediano, Fernando Rosas

et al.

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119926 - 119926

Published: Feb. 3, 2023

High-level brain functions are widely believed to emerge from the orchestrated activity of multiple neural systems. However, lacking a formal definition and practical quantification emergence for experimental data, neuroscientists have been unable empirically test this long-standing conjecture. Here we investigate fundamental question by leveraging recently proposed framework known as "Integrated Information Decomposition," which establishes principled information-theoretic approach operationalise quantify in dynamical systems - including human brain. By analysing functional MRI our results show that emergent hierarchical character dynamics is significantly diminished chronically unresponsive patients suffering severe injury. At level, demonstrate capacity positively correlated with extent organisation activity. Furthermore, combining computational approaches network control theory whole-brain biophysical modelling, reduced severely brain-injured can be mechanistically explained disruptions patients' structural connectome. Overall, suggest chronic unresponsiveness resulting injury may related impairment infrastructures required support emergence.

Language: Английский

Citations

25