A Theory and Model of Scene Representations With Hippocampal Spatial View Cells DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2025, Volume and Issue: 35(3)

Published: April 28, 2025

ABSTRACT A theory and network model are presented of how scene representations built by forming spatial view cells in the ventromedial visual cortical pathway to hippocampus primates including humans. Layer 1, corresponding V1–V4, connects 2 retrosplenial area uses competitive learning form feature combination neurons for part being fixated, a fixation patch. In 3, parahippocampal hippocampus, patches stitched together whole representations. This is performed with continuous attractor made from overlapping Gaussian receptive fields as head rotates scene. addition, gain modulation gaze direction maps correct representation when saccades made. Each neuron 3 thus cell that responds location viewed based on features The novel conceptual advances this shows may be primates, humans, scenes anchor world (to allocentric, world‐based, space); contributes this. offers revolutionary approach understanding navigation episodic memory

Language: Английский

Emotion, motivation, decision-making, the orbitofrontal cortex, anterior cingulate cortex, and the amygdala DOI Creative Commons
Edmund T. Rolls

Brain Structure and Function, Journal Year: 2023, Volume and Issue: 228(5), P. 1201 - 1257

Published: May 13, 2023

The orbitofrontal cortex and amygdala are involved in emotion motivation, but the relationship between these functions performed by brain structures is not clear. To address this, a unified theory of motivation described which motivational states instrumental goal-directed actions to obtain rewards or avoid punishers, emotional that elicited when reward punisher received. This greatly simplifies our understanding for same set genes associated systems can define primary unlearned punishers such as sweet taste pain. Recent evidence on connectivity human indicates value experienced with outputs cortical regions including those language, key region depression changes motivation. has weak effective back humans, implicated brainstem-mediated responses stimuli freezing autonomic activity, rather than declarative emotion. anterior cingulate learning rewards, ventromedial prefrontal providing goals navigation reward-related effects memory consolidation mediated partly via cholinergic system.

Language: Английский

Citations

126
The hippocampus, ventromedial prefrontal cortex, and episodic and semantic memory DOI
Edmund T. Rolls

Progress in Neurobiology, Journal Year: 2022, Volume and Issue: 217, P. 102334 - 102334

Published: July 21, 2022

Language: Английский

Citations

88
Hippocampal storage and recall of neocortical “What”–“Where” representations DOI Creative Commons
Edmund T. Rolls, Chenfei Zhang, Jianfeng Feng

et al.

Hippocampus, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Abstract A key question for understanding the function of hippocampus in memory is how information recalled from to neocortex. This was investigated a neuronal network model hippocampal system which “What” and “Where” firing rate vectors were applied separate neocortical modules, then activated entorhinal cortex dentate gyrus, CA3, CA1, cortex, backprojections showed that whole could be trained recall neocortex as retrieval cue neocortex, principle up towards theoretical capacity determined largely by number synapses onto any one neuron divided sparseness representation. The synaptic weights imported into an integrate‐and‐fire simulation same architecture, time presenting module approximately 100 ms. sufficiently fast backprojection still active neurons during storage episodic memory, this needed operate correctly These simulations also long loop neocortex–hippocampus–neocortex operates continuously may contribute complete neocortex; but positive feedback makes dynamical inherently liable pathological increase activity. Important factors contributed stability included increased inhibition CA3 CA1 keep rates low; temporal adaptation synapses, are proposed make important contribution stabilizing runaway excitation cortical circuits brain.

Language: Английский

Citations

32
The human posterior cingulate, retrosplenial, and medial parietal cortex effective connectome, and implications for memory and navigation DOI
Edmund T. Rolls, Sylvia Wirth, Gustavo Deco

et al.

Human Brain Mapping, Journal Year: 2022, Volume and Issue: 44(2), P. 629 - 655

Published: Sept. 30, 2022

The human posterior cingulate, retrosplenial, and medial parietal cortex are involved in memory navigation. functional anatomy underlying these cognitive functions was investigated by measuring the effective connectivity of Posterior Cingulate Division (PCD) regions Human Connectome Project-MMP1 atlas 171 HCP participants, complemented with diffusion tractography. First, postero-ventral parts PCD (31pd, 31pv, 7m, d23ab, v23ab) have temporal pole, inferior visual cortex, superior sulcus implicated auditory semantic processing, reward-related vmPFC pregenual anterior cingulate hippocampal system. This implicates it episodic memory, providing routes for "what," reward schema-related information to access hippocampus. Second, antero-dorsal (especially 31a 23d, PCV, also RSC) early cortical areas including those that represent spatial scenes, "where" component dorsal-transitional-visual (DVT) ProStriate where retrosplenial scene area is located from parahippocampal area, a ventromedial route reach These connectivities provide important reward, scene-related midcingulate provides dorsal supracallosal part premotor regions.

Language: Английский

Citations

60
Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans DOI Creative Commons
Edmund T. Rolls

Hippocampus, Journal Year: 2022, Volume and Issue: 33(5), P. 533 - 572

Published: Sept. 7, 2022

Abstract Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the location being looked at. The representation is allocentric, that responses are locations “out there” world, relatively invariant with respect retinal position, eye head direction, place where individual located. underlying connectivity humans from ventromedial visual cortical regions scene area, leading theory cells formed by combinations of overlapping feature inputs self‐organized based on their closeness space. Thus, although represent “where” for episodic memory navigation, they ventral stream what area. A second driver parietal inputs, which it proposed provide idiothetic update cells, used recall navigation when details obscured. Inferior temporal object “what” orbitofrontal cortex reward connect human hippocampal system, macaques can be associated hippocampus cell representations implement memory. also a basis series viewed landmarks, providing goals then implemented involved visuomotor actions presence foveate vision highly developed lobe processing including key understanding primate hippocampus, roles this system navigation.

Language: Английский

Citations

57
The human posterior parietal cortex: effective connectome, and its relation to function DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(6), P. 3142 - 3170

Published: July 14, 2022

Abstract The effective connectivity between 21 regions in the human posterior parietal cortex, and 360 cortical was measured 171 Human Connectome Project (HCP) participants using HCP atlas, complemented with functional diffusion tractography. Intraparietal areas LIP, VIP, MIP, AIP have from early visual regions, to visuomotor such as frontal eye fields, consistent functions saccades tracking. Five superior area 7 receive similar intraparietal areas, but also somatosensory inputs connect premotor including 6, performing actions reach for, grasp, manipulate objects. In anterior inferior PFop, PFt, PFcm are mainly somatosensory, PF addition receives visuo-motor object information, is implicated multimodal shape body image representations. PFm PGs combine visuo-motor, object, reward input hippocampal system. PGi provides a route motion-related temporal sulcus involved social interactions. PGp has coordinate transforms may be idiothetic update of scene

Language: Английский

Citations

52
Multiple cortical visual streams in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(7), P. 3319 - 3349

Published: July 14, 2022

The effective connectivity between 55 visual cortical regions and 360 was measured in 171 HCP participants using the HCP-MMP atlas, complemented with functional diffusion tractography. A Ventrolateral Visual "What" Stream for object face recognition projects hierarchically to inferior temporal cortex, which orbitofrontal cortex reward value emotion, hippocampal memory system. Ventromedial "Where" scene representations connects parahippocampal gyrus hippocampus. An Inferior STS (superior sulcus) Semantic receives from Stream, parietal PGi, ventromedial-prefrontal system language systems. Dorsal via V2 V3A MT+ Complex (including MT MST), connect intraparietal LIP, VIP MIP) involved motion actions space. It performs coordinate transforms idiothetic update of representations. Superior inputs STV, auditory A5, is activated by expression, vocalization, important social behaviour,

Language: Английский

Citations

43
Prefrontal and somatosensory-motor cortex effective connectivity in humans DOI
Edmund T. Rolls, Gustavo Deco, Chu‐Chung Huang

et al.

Cerebral Cortex, Journal Year: 2022, Volume and Issue: 33(8), P. 4939 - 4963

Published: Oct. 13, 2022

Abstract Effective connectivity, functional and tractography were measured between 57 cortical frontal somatosensory regions the 360 in Human Connectome Project (HCP) multimodal parcellation atlas for 171 HCP participants. A ventral stream connects from 3b 3a via 1 2 then opercular to insula, which inferior parietal PF regions. This is implicated “what”-related processing of objects body combining with visual inputs PF. dorsal “action” area 5 7. Inferior prefrontal have connectivity temporal cortex orbitofrontal cortex, are working memory “what” streams, provide language systems, including 44, 45, 47l, TPOJ1, superior area. The dorsolateral that include 46 7 actions planning. regions, 8Ad 8Av, PGs PGi, auditory top-down attention.

Language: Английский

Citations

39
Two what, two where, visual cortical streams in humans DOI Creative Commons
Edmund T. Rolls

Neuroscience & Biobehavioral Reviews, Journal Year: 2024, Volume and Issue: 160, P. 105650 - 105650

Published: April 3, 2024

ROLLS, E. T. Two What, Where, Visual Cortical Streams in Humans. NEUROSCI BIOBEHAV REV 2024. Recent cortical connectivity investigations lead to new concepts about 'What' and 'Where' visual streams humans, how they connect other systems. A ventrolateral stream leads the inferior temporal cortex for object face identity, provides information hippocampal episodic memory system, anterior lobe semantic orbitofrontal emotion system. superior sulcus (STS) utilising from parietal responds moving objects faces, expression, connects social behaviour. ventromedial builds feature combinations scenes, inputs via parahippocampal scene area system that are also useful landmark-based navigation. The dorsal pathway actions space, but coordinate transforms provide self-motion update of locations scenes dark or when view is obscured.

Language: Английский

Citations

15
A theory of hippocampal function: New developments DOI Creative Commons
Edmund T. Rolls, Alessandro Treves

Progress in Neurobiology, Journal Year: 2024, Volume and Issue: 238, P. 102636 - 102636

Published: June 2, 2024

We develop further here the only quantitative theory of storage information in hippocampal episodic memory system and its recall back to neocortex. The is upgraded account for a revolution understanding spatial representations primate, including human, hippocampus, that go beyond place where individual located, location being viewed scene. This fundamental much primate navigation: functions supported humans by pathways build 'where' view feature combinations ventromedial visual cortical stream, separate from those 'what' object face inferior temporal cortex, reward orbitofrontal cortex. Key new computational developments include capacity CA3 attractor network storing whole charts space; how correlations inherent self-organizing continuous impact capacity; can combine discrete representations; roles rewards reach hippocampus later consolidation into long-term part via cholinergic cortex; ways analysing neocortical using Potts networks.

Language: Английский

Citations

12