Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Jan. 18, 2024
Abstract
The
central
autonomic
network
(CAN)
plays
a
crucial
role
in
modulating
the
nervous
system.
Heart
rate
variability
(HRV)
is
valuable
marker
for
assessing
CAN
function
disorders
of
consciousness
(DOC)
patients.
We
used
HRV
analysis
early
prognosis
58
DOC
patients
enrolled
within
ten
days
hospitalization.
They
underwent
five-minute
electrocardiogram
during
baseline
and
acoustic/visual
stimulation.
coma
recovery
scale-revised
(CRS-R)
was
to
define
patient’s
level
categorize
good/bad
outcome
at
three
months.
high-frequency
Power
Spectrum
Density
standard
deviation
normal-to-normal
peaks
baseline,
sample
entropy
stimulation,
time
from
injury
features
were
support
vector
machine
(SVM)
prediction.
SVM
predicted
patients’
with
an
accuracy
96%
training
test
100%
validation
test,
underscoring
its
potential
provide
clinical
information
about
prognosis.
Neuroscience & Biobehavioral Reviews,
Journal Year:
2022,
Volume and Issue:
139, P. 104736 - 104736
Published: June 11, 2022
Executive
control
is
a
complex
high-level
cognitive
function
that
relies
on
distributed
brain
circuitry.
We
propose
the
anterior
insular
cortex
plays
an
under-appreciated
role
in
executive
processes,
acting
as
gatekeeper
to
other
regions
and
networks
by
virtue
of
primacy
action
effective
connectivity.
The
flexible
functional
profile
subdivision
renders
it
key
hub
within
broader
midcingulo-insular
'salience
network',
allowing
orchestrate
drive
activity
major
including
medial
frontoparietal
'default
mode
network'
lateral
'central
network'.
microanatomy
large-scale
connectivity
positions
play
critical
triaging
integrating
internal
external
multisensory
stimuli
service
initiating
higher-order
functions.
Multiple
lines
evidence
scaffold
novel
hypothesis
that,
for
integration
lever
network
switching,
insula
serves
control.
Nature Communications,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: Jan. 5, 2023
Abstract
Consciousness
is
a
multidimensional
phenomenon,
but
key
dimensions
such
as
awareness
and
wakefulness
have
been
described
conceptually
rather
than
neurobiologically.
We
hypothesize
that
of
consciousness
are
encoded
in
multiple
neurofunctional
the
brain.
analyze
cortical
gradients,
which
continua
brain’s
overarching
functional
geometry,
to
characterize
these
dimensions.
demonstrate
disruptions
human
–
due
pharmacological,
neuropathological,
or
psychiatric
causes
associated
with
degradation
one
more
major
gradients
depending
on
state.
Network-specific
reconfigurations
within
gradient
space
behavioral
unresponsiveness
various
etiologies,
spatial
correlate
temporal
disruption
structured
transitions
dynamic
brain
states.
In
this
work,
we
therefore
provide
unifying
framework
for
both
health
disease.
Trends in Neurosciences,
Journal Year:
2022,
Volume and Issue:
45(10), P. 722 - 732
Published: Aug. 19, 2022
The
role
of
the
prefrontal
cortex
(PFC)
in
mechanism
consciousness
is
a
matter
active
debate.
Most
theoretical
and
empirical
investigations
have
focused
on
whether
PFC
critical
for
content
(i.e.,
qualitative
aspects
conscious
experience).
However,
there
emerging
evidence
that,
addition
to
its
well-established
roles
cognition,
key
regulator
level
global
state
arousal).
In
this
opinion
article
we
review
recent
data
supporting
hypothesis
that
medial
node
arousal-promoting
networks.
Science,
Journal Year:
2025,
Volume and Issue:
388(6742)
Published: April 4, 2025
Human
high-order
thalamic
nuclei
activity
is
known
to
closely
correlate
with
conscious
states.
However,
it
not
clear
how
those
and
thalamocortical
interactions
directly
contribute
the
transient
process
of
human
perception.
We
simultaneously
recorded
stereoelectroencephalography
data
from
prefrontal
cortex
(PFC),
while
patients
implanted
electrodes
performed
a
visual
consciousness
task.
Compared
ventral
PFC,
intralaminar
medial
presented
earlier
stronger
consciousness-related
activity.
Transient
thalamofrontal
neural
synchrony
cross-frequency
coupling
were
both
driven
by
θ
phase
during
The
thus
play
gate
role
drive
PFC
emergence
