Cardiomyocyte regeneration after infarction: changes, opportunities and challenges DOI
Ce Cao, Lili Yang, Jianshu Song

et al.

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Language: Английский

Resurrection of endogenous retroviruses during aging reinforces senescence DOI Creative Commons
Xiaoqian Liu, Zunpeng Liu, Zeming Wu

et al.

Cell, Journal Year: 2023, Volume and Issue: 186(2), P. 287 - 304.e26

Published: Jan. 1, 2023

Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened contribute to the aging process is largely unknown. In human senescent cells, we found that HERVK (HML-2), most recently integrated ERVs, are unlocked transcribe genes produce retrovirus-like particles (RVLPs). These RVLPs constitute a transmissible message elicit senescence phenotypes young which be blocked by neutralizing antibodies. The activation of ERVs was also observed organs aged primates mice well tissues serum from elderly. Their repression alleviates cellular tissue degeneration and, some extent, organismal aging. findings indicate resurrection hallmark driving force

Language: Английский

Citations

211
Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

197
Stress, epigenetics, and aging: Unraveling the intricate crosstalk DOI Creative Commons
Zeming Wu, Jing Qu, Weiqi Zhang

et al.

Molecular Cell, Journal Year: 2023, Volume and Issue: 84(1), P. 34 - 54

Published: Nov. 13, 2023

Language: Английский

Citations

54
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body DOI Creative Commons
Shuhui Sun, Shuai Ma, Yusheng Cai

et al.

The Innovation, Journal Year: 2023, Volume and Issue: 4(1), P. 100380 - 100380

Published: Jan. 1, 2023

•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized phenotypic molecular adaptations a 12-month 14 tissues/organs at single-cell resolution. Overall, although more effectively animals, individuals terms inflammaging suppression tissue rejuvenation, structural improvement central system systemic vasculature being most prominent. In vascular endothelial cells, found that readjusting rhythmic machinery core BMAL1 delayed senescence facilitated recovery damage, recapitulating beneficial effects exercise. Our study underscores effect reconstituting youthful network provides foundation for further investigating interplay between aging, immune challenges organism.

Language: Английский

Citations

46
Depletion of SAM leading to loss of heterochromatin drives muscle stem cell ageing DOI
Jengmin Kang,

Daniel I. Benjamin,

Soochi Kim

et al.

Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 153 - 168

Published: Jan. 19, 2024

Language: Английский

Citations

23
The pathobiology of neurovascular aging DOI
Monica M. Santisteban, Costantino Iadecola

Neuron, Journal Year: 2025, Volume and Issue: 113(1), P. 49 - 70

Published: Jan. 1, 2025

Language: Английский

Citations

3
Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation DOI Creative Commons

Yaobin Jing,

Xiaoyu Jiang, Qianzhao Ji

et al.

Cell stem cell, Journal Year: 2023, Volume and Issue: 30(11), P. 1452 - 1471.e10

Published: Oct. 12, 2023

Language: Английский

Citations

25
Decoding aging-dependent regenerative decline across tissues at single-cell resolution DOI Creative Commons
Yusheng Cai,

Muzhao Xiong,

Zijuan Xin

et al.

Cell stem cell, Journal Year: 2023, Volume and Issue: 30(12), P. 1674 - 1691.e8

Published: Oct. 27, 2023

Language: Английский

Citations

17
Advanced Nano Delivery System for Stem Cell Therapy for Alzheimer's Disease DOI
Yilong Pan,

Long Li,

Ning Cao

et al.

Biomaterials, Journal Year: 2024, Volume and Issue: 314, P. 122852 - 122852

Published: Sept. 30, 2024

Language: Английский

Citations

8
Transcriptional repression across mitosis: mechanisms and functions DOI Creative Commons
Alejandra Contreras‐Ramos, Carlos Perea-Resa

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: 52(1), P. 455 - 464

Published: Feb. 19, 2024

Transcription represents a central aspect of gene expression with RNA polymerase machineries (RNA Pol) driving the synthesis from DNA template molecules. In eukaryotes, total three Pol enzymes generate plethora species and II is one transcribing all protein-coding genes. A high number cis- trans-acting factors orchestrates II-mediated transcription by influencing chromatin recruitment, activation, elongation, and/or termination steps. The levels accessibility, defining open-euchromatin versus close-heterochromatin, delimits activity as well encounter other acting on such replication or repair machineries. stage cell cycle highly influences mitosis representing major challenge. fact, there massive inhibition during mitotic entry coupled dissociation most components transcriptional machinery. Mitosis, consequence, compromises memory perpetuation cellular identity. Once ends, immediately recover to define fate safeguard proper progression daughter cells through cycle. this review, we evaluate our current understanding repression associated special focus molecular mechanisms involved, potential function behind general repression, transmission machinery into cells. We finally discuss contribution that errors in inheritance across might play stem aging.

Language: Английский

Citations

6