bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 5, 2024
Abstract
To
elucidate
the
aging-associated
cellular
population
dynamics
throughout
body,
here
we
present
PanSci,
a
single-cell
transcriptome
atlas
profiling
over
20
million
cells
from
623
mouse
tissue
samples,
encompassing
range
of
organs
across
different
life
stages,
sexes,
and
genotypes.
This
comprehensive
dataset
allowed
us
to
identify
more
than
3,000
unique
states
catalog
200
distinct
cell
populations
experiencing
significant
depletion
or
expansion.
Our
panoramic
analysis
uncovered
temporally
structured,
organ-
lineage-specific
shifts
during
lifespan
progression.
Moreover,
investigated
alterations
in
immune
populations,
revealing
both
widespread
organ-specific
changes.
We
further
explored
regulatory
roles
system
on
aging
pinpointed
specific
age-related
expansions
that
are
lymphocyte-dependent.
The
breadth
depth
our
‘cell-omics’
methodology
not
only
enhance
comprehension
but
also
lay
groundwork
for
exploring
complex
networks
among
varied
types
context
diseases.
One
Sentence
Summary
lifespan,
unveils
temporal
architecture
dynamics,
shifts,
lymphocyte’s
role
organismal
aging.
npj Women s Health,
Journal Year:
2025,
Volume and Issue:
3(1)
Published: Feb. 25, 2025
Osteoarthritis
(OA)
is
a
chronic
joint
disease
characterized
by
cartilage
degradation,
inflammation,
and
pain.
While
multiple
factors
contribute
to
OA
development,
age
sex
are
primary
risk
factors,
particularly
affecting
postmenopausal
women.
The
dramatic
increase
in
after
menopause
suggests
estrogen
deficiency
accelerates
progression.
This
review
explores
the
molecular
mechanisms
connecting
aging
focusing
on
key
genes
pathways
identified
through
RNA
sequencing.
Aging,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 16, 2024
Aging
|
doi:10.18632/aging.206135.
Yu-Xuan
Lyu,
Qiang
Fu,
Dominika
Wilczok,
Kejun
Ying,
Aaron
King,
Adam
Antebi,
Aleksandar
Vojta,
Alexandra
Stolzing,
Alexey
Moskalev,
Anastasia
Georgievskaya,
Andrea
B.
Maier,
Olsen,
Anja
Groth,
Anna
Katharina
Simon,
Anne
Brunet,
Aisyah
Jamil,
Anton
Kulaga,
Asif
Bhatti,
Benjamin
Yaden,
Bente
Klarlund
Pedersen,
Björn
Schumacher,
Boris
Djordjevic,
Brian
Kennedy,
Chieh
Chen,
Christine
Yuan
Huang,
Christoph
U.
Correll,
Coleen
T.
Murphy,
Collin
Y.
Ewald,
Danica
Dario
Riccardo
Valenzano,
Dariusz
Sołdacki,
David
Erritzoe,
Meyer,
A.
Sinclair,
Eduardo
Nunes
Chini,
Emma
C.
Teeling,
Eric
Morgen,
Verdin,
Erik
Vernet,
Estefano
Pinilla,
Evandro
F.
Fang,
Evelyne
Bischof,
Evi
M.
Mercken,
Fabian
Finger,
Folkert
Kuipers,
Frank
W.
Pun,
Gabor
Gyülveszi,
Gabriele
Civiletto,
Garri
Zmudze,
Gil
Blander,
Harold
Pincus,
Joshua
McClure,
James
L.
Kirkland,
Peyer,
Jamie
N.
Justice,
Jan
Vijg,
Jennifer
R.
Gruhn,
Jerry
McLaughlin,
Joan
Mannick,
João
Passos,
Joseph
Baur,
Joe
Betts-LaCroix,
John
Sedivy,
Speakman,
Jordan
Shlain,
Julia
von
Maltzahn,
Katrin
I.
Andreasson,
Kelsey
Moody,
Konstantinos
Palikaras,
Kristen
Fortney,
Laura
J.
Niedernhofer,
Lene
Juel
Rasmussen,
Liesbeth
Veenhoff,
Lisa
Melton,
Luigi
Ferrucci,
Marco
Quarta,
Maria
Koval,
Marinova,
Mark
Hamalainen,
Maximilian
Unfried,
Michael
S.
Ringel,
Milos
Filipovic,
Mourad
Topors,
Natalia
Mitin,
Nawal
Roy,
Nika
Pintar,
Nir
Barzilai,
Paolo
Binetti,
Parminder
Singh,
Paul
Kohlhaas,
D.
Robbins,
Rubin,
Peter
O.
Fedichev,
Petrina
Kamya,
Pura
Muñoz-Canoves,
Rafael
de
Cabo,
Richard
G.
Faragher,
Rob
Konrad,
Roberto
Ripa,
Robin
Mansukhani,
Sabrina
Büttner,
Sara
Wickström,
Sebastian
Brunemeier,
Sergey
Jakimov,
Shan
Luo,
Sharon
Rosenzweig-Lipson,
Shih-Yin
Tsai,
Stefanie
Dimmeler,
Thomas
Rando,
Tim
Peterson,
Tina
Woods,
Tony
Wyss-Coray,
Toren
Finkel,
Tzipora
Strauss,
Vadim
Gladyshev,
Valter
Longo,
Varun
Dwaraka,
Vera
Gorbunova,
Victoria
Acosta-Rodríguez,
Vincenzo
Sorrentino,
Vittorio
Sebastiano,
Wenbin
Li,
Yousin
Suh,
Alex
Zhavoronkov,
Morten
Scheibye-Knudsen,
Daniela
Bakula
The Journal of Biochemistry,
Journal Year:
2024,
Volume and Issue:
175(5), P. 525 - 537
Published: Feb. 15, 2024
Abstract
Cellular
senescence
occurs
in
response
to
endogenous
or
exogenous
stresses
and
is
characterized
by
stable
cell
cycle
arrest,
alterations
nuclear
morphology
secretion
of
proinflammatory
factors,
referred
as
the
senescence-associated
secretory
phenotype
(SASP).
An
increase
senescent
cells
associated
with
development
several
types
cancer
aging-related
diseases.
Therefore,
senolytic
agents
that
selectively
remove
may
offer
opportunities
for
developing
new
therapeutic
strategies
against
such
cancers
This
review
outlines
inducers
general
characteristics
cells.
We
also
discuss
involvement
certain
Finally,
we
describe
a
series
their
utilization
strategies.
Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
To
elucidate
aging-associated
cellular
population
dynamics,
we
present
PanSci
,
a
single-cell
transcriptome
atlas
profiling
over
20
million
cells
from
623
mouse
tissues
across
different
life
stages,
sexes,
and
genotypes.
This
comprehensive
dataset
reveals
more
than
3,000
unique
states
200
cell
populations.
Our
panoramic
analysis
uncovered
organ-,
lineage-,
sex-specific
shifts
of
dynamics
during
lifespan
progression.
Moreover,
identify
both
systematic
organ-specific
alterations
in
immune
populations
associated
with
aging.
We
further
explored
the
regulatory
roles
system
on
aging
pinpointed
specific
age-related
expansions
that
are
lymphocyte
dependent.
“cell-omics”
strategy
enhances
comprehension
lays
groundwork
for
exploring
complex
networks
diseases.
Abstract
Osteoarthritis
(OA),
known
as
one
of
the
most
common
types
aseptic
inflammation
musculoskeletal
system,
is
characterized
by
chronic
pain
and
whole-joint
lesions.
With
cellular
molecular
changes
including
senescence,
inflammatory
alterations,
subsequent
cartilage
defects,
OA
eventually
leads
to
a
series
adverse
outcomes
such
disability.
CRISPR-Cas-related
technology
has
been
proposed
explored
gene
therapy,
offering
potential
gene-editing
tools
that
are
in
spotlight.
Considering
genetic
multigene
regulatory
mechanisms
OA,
we
systematically
review
current
studies
on
CRISPR-Cas
for
improving
terms
inflammation,
damage
summarize
various
strategies
delivering
CRISPR
products,
hoping
provide
new
perspective
treatment
taking
advantage
technology.
