Characterization of the neural circuitry of the auditory thalamic reticular nucleus and its potential role in salicylate-induced tinnitus DOI Creative Commons
Qian Dai,

Tong Qu,

Guo-Ming Shen

et al.

Frontiers in Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: April 2, 2024

Introduction Subjective tinnitus, the perception of sound without an external acoustic source, is often subsequent to noise-induced hearing loss or ototoxic medications. The condition believed result from neuroplastic alterations in auditory centers, characterized by heightened spontaneous neural activities and increased synchrony due imbalance between excitation inhibition. However, role thalamic reticular nucleus (TRN), a structure composed exclusively GABAergic neurons involved thalamocortical oscillations, pathogenesis tinnitus remains largely unexplored. Methods We induced mice using sodium salicylate assessed tinnitus-like behaviors Gap Pre-Pulse Inhibition Acoustic Startle (GPIAS) paradigm. utilized combined viral tracing techniques identify circuitry employed immunofluorescence confocal imaging determine cell types activated neurons. Results Salicylate-treated exhibited behaviors. Our clearly delineated inputs outputs auditory-specific TRN. discovered that chemogenetic activation TRN significantly reduced salicylate-evoked rise c-Fos expression cortex. Discussion This finding posits as potential modulatory target for treatment. Furthermore, mapped sensory suggest possibilities employing optogenetic stimulations manipulate activities. precise mapping TRN-mediated pathways offers promising avenue designing targeted interventions alleviate symptoms.

Language: Английский

Neural circuits mediating chronic stress: Implications for major depressive disorder DOI
Hongling Guo, Tahir Ali, Shupeng Li

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: 137, P. 111280 - 111280

Published: Feb. 3, 2025

Language: Английский

Citations

1
Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain DOI Creative Commons
Giada Mascio, Serena Notartomaso, Roxana Paula Ginerete

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: March 17, 2025

Abstract We moved from the hypothesis that perineuronal nets (PNNs), which are condensed structures of extracellular matrix surrounding GABAergic interneurons in forebrain, contribute to mechanisms maladaptive neuronal plasticity underlying chronic pain. Here, we found density PNNs labelled with lectin Wisteria Floribunda Agglutinin (WFA) increased contralateral somatosensory cortex (SSC), medial prefrontal (mPFC), reticular thalamic nucleus (RTN), and insular mice developing neuropathic pain response unilateral constriction injury sciatic nerve. These regions involved circuits perception, sufferance, embodiment, top-down control At least SSC mPFC, WFA + was associated an up-regulation proteoglycans, brevican neurocan, as shown by immunoblot analysis. Enzymatic degradation caused local infusion chondroitinase ABC or RTN enhanced both mechanical thermal thresholds mice. In contrast, siRNA-induced knock-down PNN-degrading enzyme, type-9 metalloproteinase (MMP-9), lowered sham-operated data, combined our previous findings obtained inflammatory pain, suggest formation/reduced is different types may drive nociceptive sensitization leading reduced thresholds.

Language: Английский

Citations

1
The behavioral relevance of a modular organization in the lateral habenula DOI Creative Commons
Léo Michel, Patricia E. Molina, Manuel Mameli

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(16), P. 2669 - 2685

Published: May 20, 2024

Behavioral strategies for survival rely on the updates brain continuously makes based surrounding environment. External stimuli—neutral, positive, and negative—relay core information to brain, where a complex anatomical network rapidly organizes actions, including approach or escape, regulates emotions. Human neuroimaging physiology in nonhuman primates, rodents, teleosts suggest pivotal role of lateral habenula translating external into behaviors. Here, we review literature describing how discrete habenular modules—reflecting molecular signatures, connectivity, functional components—are recruited by environmental stimuli cooperate prompt specific behavioral outcomes. We argue that integration these findings context valence processing reinforcing discouraging behaviors is necessary, offering compelling model guide future work.

Language: Английский

Citations

5
Altered habenular connectivity in chronic low back pain: An fMRI and machine learning study DOI Creative Commons
Cuiping Mao,

Yue Wu,

Hua Yang

et al.

Human Brain Mapping, Journal Year: 2023, Volume and Issue: 44(11), P. 4407 - 4421

Published: June 12, 2023

The habenula has been implicated in the pathogenesis of pain and analgesia, while evidence concerning its function chronic low back (cLBP) is sparse. This study aims to investigate resting-state functional connectivity (rsFC) effective 52 patients with cLBP healthy controls (HCs) assess feasibility distinguishing from HCs based on by machine learning methods. Our results indicated significantly enhanced rsFC habenula-left superior frontal cortex (SFC), habenula-right thalamus, habenula-bilateral insular pathways as well decreased habenula-pons pathway compared HCs. Dynamic causal modelling revealed right thalamus RsFC habenula-SFC was positively correlated intensities Hamilton Depression scores group. insula negatively duration Additionally, combination habenula-SFC, habenula-thalamus, could reliably distinguish an accuracy 75.9% support vector machine, which validated independent cohort (N = 68, 68.8%, p .001). Linear regression random forest also (accuracy 73.9 55.9%, respectively). Overall, these findings provide that may be associated abnormal habenula, highlight promise discrimination.

Language: Английский

Citations

12
Paraventricular thalamus‐insular cortex circuit mediates colorectal visceral pain induced by neonatal colonic inflammation in mice DOI Creative Commons

Fu‐Chao Zhang,

Ying‐Xue Wei,

Rui‐Xia Weng

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2023, Volume and Issue: 30(4)

Published: Nov. 23, 2023

Abstract Aims Irritable bowel syndrome (IBS) is a common functional gastrointestinal disorder, but its pathogenesis remains incompletely understood, particularly the involvements of central nervous system sensitization in colorectal visceral pain. Our study was to investigate whether paraventricular thalamus (PVT) projected insular cortex (IC) regulate pain neonatal colonic inflammation (NCI) mice and underlying mechanisms. Methods We applied optogenetic, chemogenetic, or pharmacological approaches manipulate glutamatergic PVT‐IC pathway. Fiber photometry used assess neuronal activity. Electromyography activities response distension (CRD) were measured evaluate Results NCI enhanced c‐Fos expression calcium activity upon CRD IC Glu , optogenetic manipulation them altered responses accordingly. Viral tracing indicated that PVT . Optogenetic changed responses. Furthermore, selective modulation projections influenced pain, which reversed by chemogenetic downstream Conclusions This identified novel neural circuit playing critical role mouse model IBS.

Language: Английский

Citations

11
Chronic Neuropathic Pain and Comorbid Depression Syndrome: From Neural Circuit Mechanisms to Treatment DOI
Yue Zhang,

Hui Ma,

Yafan Bai

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(13), P. 2432 - 2444

Published: June 25, 2024

Chronic neuropathic pain and comorbid depression syndrome (CDS) is a major worldwide health problem that affects the quality of life patients imposes tremendous socioeconomic burden. More than half with chronic also suffer from moderate or severe depression. Due to complex pathogenesis CDS, there are no effective therapeutic drugs available. The lack research on neural circuit mechanisms CDS limits development treatments. purpose this article provide an overview various circuits involved in CDS. Notably, activating some can alleviate and/or depression, while other exacerbate these conditions. Moreover, we discuss current emerging pharmacotherapies for such as ketamine. Understanding may clues novel drug treatments improved management.

Language: Английский

Citations

4
Disturbed hierarchy and mediation in reward-related circuits in depression DOI Creative Commons

Ruikun Yang,

Junxia Chen,

Suping Yue

et al.

NeuroImage Clinical, Journal Year: 2025, Volume and Issue: 45, P. 103739 - 103739

Published: Jan. 1, 2025

Language: Английский

Citations

0
The characteristics of brain function alterations in patients with chronic prostatitis/chronic pelvic pain syndrome across varying symptom severities evaluated by NIH-CPSI DOI Creative Commons
Shengyang Ge,

Yun‐Ting Xiang,

Xu‐Yun Hua

et al.

Frontiers in Neuroscience, Journal Year: 2025, Volume and Issue: 19

Published: Feb. 26, 2025

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a prevalent condition in urology characterized by chronic pain. The pathogenesis of CP/CPPS remains unclear. We enrolled 45 eligible patients and healthy volunteers. evaluated their resting-state fMRI data using comprehensive set parameters, such as Regional Homogeneity (ReHo) Degree Centrality (DC), to detect brain abnormalities identify potential correlates with the clinical manifestations CP/CPPS. further categorized into subgroups according scores NIH-CPSI elucidate changes associated differing symptom severities. Profound alterations function were observed These involved multiple regions identified DC analysis, including right anterior cingulate cortex (ACC), left inferior frontal opercular cortex, amygdala, middle bilateral insula. ReHo analysis revealed significant thalamus, triangular superior temporal pole, ACC, (cluster >20 voxels, GRF correction, p < 0.05). Analysis that varying severities localized perception modulation regions. Specifically, values ACC showed linear correlation severity symptoms measured (AUC = 0.9654, 0.0001). In CP/CPPS, we first discovered differences among degrees severity. might be biomarker for diagnosing assessing disease

Language: Английский

Citations

0
Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics DOI
Taida Huang, Xiaonan Guo, Xiaomin Huang

et al.

Journal of Zhejiang University SCIENCE B, Journal Year: 2024, Volume and Issue: unknown

Published: April 3, 2024

Language: Английский

Citations

3
Dorsal raphe dopaminergic neurons target CaMKII+ neurons in dorsal bed nucleus of the stria terminalis for mediating depression-related behaviors DOI Creative Commons
Wentao Wang, Dan Wang,

Di Zhao

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 2, 2024

Language: Английский

Citations

3