Gut Microbiome–Brain Alliance: A Landscape View into Mental and Gastrointestinal Health and Disorders DOI Creative Commons
Janet M. Sasso, Ramy M. Ammar,

Rumiana Tenchov

et al.

ACS Chemical Neuroscience, Journal Year: 2023, Volume and Issue: 14(10), P. 1717 - 1763

Published: May 8, 2023

Gut microbiota includes a vast collection of microorganisms residing within the gastrointestinal tract. It is broadly recognized that gut and brain are in constant bidirectional communication, which its metabolic production major component, form so-called microbiome–brain axis. Disturbances homeostasis caused by imbalance their functional composition activities, known as dysbiosis, cause dysregulation these pathways trigger changes blood–brain barrier permeability, thereby causing pathological malfunctions, including neurological disorders. In turn, can affect structure function through autonomic nervous system regulating motility, intestinal transit secretion, permeability. Here, we examine data from CAS Content Collection, largest published scientific information, analyze publication landscape recent research. We review advances knowledge related to human microbiome, complexity functionality, communication with central system, effect axis on mental health. discuss correlations between various diseases, specifically also explore metabolites regard impact associated diseases. Finally, assess clinical applications gut-microbiota-related substances development pipelines. hope this serve useful resource understanding current emerging field an effort further solving remaining challenges fulfilling potential.

Language: Английский

The Controversial Role of Human Gut Lachnospiraceae DOI Creative Commons
Mirco Vacca, Giuseppe Celano, Francesco Maria Calabrese

et al.

Microorganisms, Journal Year: 2020, Volume and Issue: 8(4), P. 573 - 573

Published: April 15, 2020

The complex polymicrobial composition of human gut microbiota plays a key role in health and disease. Lachnospiraceae belong to the core microbiota, colonizing intestinal lumen from birth increasing, terms species richness their relative abundances during host's life. Although, members are among main producers short-chain fatty acids, different taxa also associated with intra- extraintestinal diseases. Their impact on host physiology is often inconsistent across studies. Here, we discuss changes according With aim harnessing promote health, analyze how nutrients diet can influence growth metabolites can, turn, physiology.

Language: Английский

Citations

1188
The Microbiota-Gut-Brain Axis: From Motility to Mood DOI Creative Commons
Kara Gross Margolis, John F. Cryan, Emeran A. Mayer

et al.

Gastroenterology, Journal Year: 2021, Volume and Issue: 160(5), P. 1486 - 1501

Published: Jan. 22, 2021

Language: Английский

Citations

646
Enlightening the taxonomy darkness of human gut microbiomes with a cultured biobank DOI Creative Commons
Chang Liu, Meng-Xuan Du,

Rexiding Abuduaini

et al.

Microbiome, Journal Year: 2021, Volume and Issue: 9(1)

Published: May 21, 2021

Abstract Background In gut microbiome studies, the cultured microbial resource plays essential roles, such as helping to unravel functions and host-microbe interactions. Although several major studies have been performed elucidate human microbiota, up 70% of Unified Human Gastrointestinal Genome species not date. Large-scale isolation identification well availability public are imperative for further characterizing functions. Results this study, we constructed a Gut Microbial Biobank (hGMB; homepage: hgmb.nmdc.cn ) through cultivation 10,558 isolates from 31 sample mixtures 239 fresh fecal samples healthy Chinese volunteers, deposited 1170 strains representing 400 different in culture collections International Depository Authority long-term preservation access worldwide. Following rules Code Nomenclature Prokaryotes, 102 new were characterized denominated, while 28 genera 3 families proposed. hGMB represented over 80% common dominant global 16S rRNA gene amplicon data ( n = 11,647) 24 “most-wanted” “medium priority” taxa proposed by Microbiome Project. We total sequenced 115 genomes novel 13 previously known species. Further silico analysis revealed that newly 22 uncultured (UHGG) contributed representatives potentially “dark taxa” had discovered UHGG. The nonredundant catalogs generated covered 50% functionally genes (KEGG orthologs) largest approximately 10% “most wanted” unknown proteins FUnkFams database. Conclusions A publicly accessible (hGMB) was established contained represents expands resources genomic repository adding species, genera, families, microbes.

Language: Английский

Citations

527
Sex Differences in Gut Microbiota DOI Creative Commons
Yong Sung Kim, Tatsuya Unno, Byung‐Yong Kim

et al.

The World Journal of Men s Health, Journal Year: 2019, Volume and Issue: 38(1), P. 48 - 48

Published: March 27, 2019

Humans carry numerous symbiotic microorganisms in their body, most of which are present the gut. Although recent technological advances have produced extensive research data on gut microbiota, there various confounding factors (e.g., diet, race, medications) to consider. Sex is one important variables affecting but association has not yet been sufficiently investigated. results inconsistent, several animal and human studies shown sex differences microbiota. Herein, we review these discuss sex-dependent as well possible mechanisms involved.

Language: Английский

Citations

464
The Gut–Brain Axis DOI Open Access
Emeran A. Mayer, Karina Nance,

Shelley Chen

et al.

Annual Review of Medicine, Journal Year: 2021, Volume and Issue: 73(1), P. 439 - 453

Published: Oct. 20, 2021

Preclinical evidence has firmly established bidirectional interactions among the brain, gut, and gut microbiome. Candidate signaling molecules at least three communication channels have been identified. Communication within this system is nonlinear, with multiple feedback loops, likely involves between different channels. Alterations in gut-brain-microbiome identified rodent models of several digestive, psychiatric, neurological disorders. While alterations gut-brain clearly irritable bowel syndrome, a causative role microbiome syndrome remains to be determined. In absence specific microbial targets for more effective therapies, current approaches are limited dietary interventions centrally targeted pharmacological behavioral approaches. A comprehensive understanding influences well-designed randomized controlled trials needed translate these exciting preclinical findings into therapies.

Language: Английский

Citations

448
Probiotics Regulate Gut Microbiota: An Effective Method to Improve Immunity DOI Creative Commons
Wang Xinzhou, Peng Zhang, Xin Zhang

et al.

Molecules, Journal Year: 2021, Volume and Issue: 26(19), P. 6076 - 6076

Published: Oct. 8, 2021

Probiotics are beneficial active microorganisms that colonize the human intestines and change composition of flora in particular parts host. Recently, use probiotics to regulate intestinal improve host immunity has received widespread attention. Recent evidence shown play significant roles gut microbiota composition, which can inhibit colonization pathogenic bacteria intestine, help build a healthy mucosa protective layer, enhance immune system. Based on close relationship between immunity, it become an extremely effective way by regulating microbiome with probiotics. In this review, we discussed influence probiotics, microbiota, life quality. We further emphasized regulation microflora through thereby enhancing improving people’s lives.

Language: Английский

Citations

313
Maturation of the gut microbiome during the first year of life contributes to the protective farm effect on childhood asthma DOI
Martin Depner, Diana H. Taft, Pirkka V. Kirjavainen

et al.

Nature Medicine, Journal Year: 2020, Volume and Issue: 26(11), P. 1766 - 1775

Published: Nov. 1, 2020

Language: Английский

Citations

285
The Commensal Microbiota and Viral Infection: A Comprehensive Review DOI Creative Commons
Na Li, Wentao Ma,

Ming Pang

et al.

Frontiers in Immunology, Journal Year: 2019, Volume and Issue: 10

Published: July 4, 2019

The human body is inhabited by a diverse microbial community that collectively coined as commensal microbiota. Recent research has greatly advanced our understanding of how the microbiota affects host health. Among various kinds pathogenic infections host, viral constitute one most serious public health problems worldwide. During infection process, viruses may have substantial and intimate interactions with A plethora evidence suggests regulates in turn regulated invading through mechanisms, thereby having stimulatory or suppressive roles infections. Furthermore, integrity can be disturbed viruses, causing dysbiosis further influencing virus infectivity. In present article, we discuss current insights into regulation We also draw attention to disruption homeostasis several viruses.

Language: Английский

Citations

246
Inflammatory bowel disease is associated with higher dementia risk: a nationwide longitudinal study DOI
Bing Zhang, Hohui E. Wang, Ya‐Mei Bai

et al.

Gut, Journal Year: 2020, Volume and Issue: 70(1), P. 85 - 91

Published: June 23, 2020

Increasing evidence supports reciprocal communication between the enteric and central nervous system in disease, termed 'gut-brain axis'. Recent findings suggest a connection IBD development of Parkinson's disease. The role dementia, another insidious neurodegenerative disorder, has not been explored.

Language: Английский

Citations

238
Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms DOI Creative Commons
Justyna Godos, Walter Currenti, Donato Angelino

et al.

Antioxidants, Journal Year: 2020, Volume and Issue: 9(4), P. 346 - 346

Published: April 23, 2020

Over the last decades, there has been a substantial increase in prevalence of mental health disorders, including an increased depression, anxiety, cognitive, and sleep disorders. Diet its bioactive components have recognized among modifiable risk factors, possibly influencing their pathogenesis. This review aimed to summarize molecular mechanisms underlying putative beneficial effects toward brain different dietary such as micro- macronutrient intake habits, feeding time circadian rhythm. The role hormonal homeostasis context glucose metabolism adiponectin regulation impact on systemic neuro-inflammation also considered deepened. In addition, effect individual molecules exerting antioxidant activities acting anti-inflammatory agents, omega-3 fatty acids polyphenols, for central nervous system via modulation adult neurogenesis, synaptic neuronal plasticity, microglia activation summarized. An overview gut–brain axis inflammation oxidative stress provided. Finally, association with

Language: Английский

Citations

209