The Microbiota–Gut–Brain Axis and Alzheimer’s Disease: Neuroinflammation Is to Blame?

Nutrients, Journal Year: 2020, Volume and Issue: 13(1), P. 37 - 37

Published: Dec. 24, 2020

For years, it has been reported that Alzheimer’s disease (AD) is the most common cause of dementia. Various external and internal factors may contribute to early onset AD. This review highlights a contribution disturbances in microbiota–gut–brain (MGB) axis development Alteration gut microbiota composition determined by increase permeability barrier immune cell activation, leading impairment blood–brain function promotes neuroinflammation, neuronal loss, neural injury, ultimately Numerous studies have shown plays crucial role brain changes behavior individuals formation bacterial amyloids. Lipopolysaccharides amyloids synthesized can trigger cells residing activate response neuroinflammation. Growing experimental clinical data indicate prominent dysbiosis microbiota–host interactions Modulation with antibiotics or probiotic supplementation create new preventive therapeutic options Accumulating evidences affirm research on MGB involvement AD necessary for treatment targets therapies

Language: Английский

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Association between diet and sleep quality: A systematic review

Sleep Medicine Reviews, Journal Year: 2021, Volume and Issue: 57, P. 101430 - 101430

Published: Jan. 18, 2021

Language: Английский

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Phenolic Acids and Prevention of Cognitive Decline: Polyphenols with a Neuroprotective Role in Cognitive Disorders and Alzheimer’s Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(4), P. 819 - 819

Published: Feb. 15, 2022

Cognitive impairment, also known as cognitive decline, can occur gradually or suddenly and be temporary more permanent. It represents an increasingly important public health problem depend on normal aging linked to different neurodegenerative disorders, including Alzheimer’s disease (AD). is now well-established that lifestyle factors dietary patterns play role in healthy well the prevention of decline later life. Among natural compounds, polyphenols phenolic acids have been recently focus major attention, with their supplementation being associated better status decline. Despite therapeutic potential, human studies investigating relation between intake outcomes are rather scarce. In this review, we provide preclinical evidence such rosmarinic acid, ellagic cinnamic aldehyde exert neuroprotective pro-cognitive activities through molecular mechanisms modulation pro-oxidant antioxidant machinery inflammatory status. Future numerous vivo needed strengthen promising results obtained at level. excellent pharmacokinetic properties acids, which able accumulated brain pharmacologically relevant levels, future should identify among metabolites produced a consequence acids’ consumption may responsible for potential effects subgroup polyphenols.

Language: Английский

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Importance of EPA and DHA Blood Levels in Brain Structure and Function

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1074 - 1074

Published: March 25, 2021

Brain structure and function depend on a constant sufficient supply with eicosapentaenoic acid (EPA) docosahexaenoic (DHA) by blood. Blood levels of EPA DHA reflect dietary intake other variables are preferably assessed as percentage in erythrocytes well-documented standardized analytical method (HS-Omega-3 Index®). Every human being has an Omega-3 Index between 2 20%, optimum 8–11%. Compared to optimal Index, lower was associated increased risk for total mortality ischemic stroke, reduced brain volume, impaired cognition, accelerated progression dementia, psychiatric diseases, compromises complex functions, issues epidemiologic studies. Most intervention trials, their meta-analyses considered drugs good bioavailability, design tending produce meaningful results populations characterized low baseline blood (e.g., major depression), but otherwise responsible many neutral substantial confusion. When trial were evaluated using measured, effects larger than comparing placebo groups, paralleled findings. This indicates future design, suggests targeted use DHA, based the Index.

Language: Английский

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Nutrition and mental health: A review of current knowledge about the impact of diet on mental health

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Aug. 22, 2022

Applied psychopharmacotherapy and psychotherapy do not always bring the expected results in treatment of mental disorders. As a result, other interventions are receiving increasing attention. In recent years, there has been surge research on effects nutrition status, which may be an important aspect prevention many disorders and, at same time, lead to reduction proportion people with This review aims answer whether what extent lifestyle related affect health is scientific evidence supporting link between diet health. A was conducted based available literature by typing phrases using methodological tool PubMed database. The search yielded 3,473 records, from 356 sources directly topic study were selected, then those highest value selected according bibliometric impact factors. context current changes, urbanization, globalization, including food industry, changes people's lifestyles eating habits, correlations these phenomena their state become important. Knowledge creates potential opportunities implement new effective dietary, pharmacological, therapeutic, above all preventive interventions. therapeutic seen rational diet, physical activity, use psychobiotics, consumption antioxidants. Research also shows that nutritional have psychoprotective potential.

Language: Английский

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The Role of Gut Microbiota in Anxiety, Depression, and Other Mental Disorders as Well as the Protective Effects of Dietary Components

Nutrients, Journal Year: 2023, Volume and Issue: 15(14), P. 3258 - 3258

Published: July 23, 2023

The number of individuals experiencing mental disorders (e.g., anxiety and depression) has significantly risen in recent years. Therefore, it is essential to seek prevention treatment strategies for disorders. Several gut microbiota, especially Firmicutes Bacteroidetes, are demonstrated affect health through microbiota-gut-brain axis, the microbiota dysbiosis can be related disorders, such as anxiety, depression, other On hand, dietary components, including probiotics Lactobacillus Bifidobacterium), prebiotics fiber alpha-lactalbumin), synbiotics, postbiotics short-chain fatty acids), dairy products, spices Zanthoxylum bungeanum, curcumin, capsaicin), fruits, vegetables, medicinal herbs, so on, could exert protective effects against by enhancing beneficial while suppressing harmful ones. In this paper, disorder-associated summarized. addition, components on targeting discussed. This paper helpful develop some natural products into pharmaceuticals functional foods prevent treat

Language: Английский

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The Burden of Carbohydrates in Health and Disease

Nutrients, Journal Year: 2022, Volume and Issue: 14(18), P. 3809 - 3809

Published: Sept. 15, 2022

Foods high in carbohydrates are an important part of a healthy diet, since they provide the body with glucose to support bodily functions and physical activity. However, abusive consumption refined, simple, low-quality has direct implication on mental pathophysiology. Then, carbohydrate is postulated as crucial factor development main Western diseases 21st century. We conducted this narrative critical review using MedLine (Pubmed), Cochrane (Wiley), Embase, CinAhl databases MeSH-compliant keywords: evolution, development, phylogenetic, GUT, microbiota, stress, metabolic health, behaviors, disease, cardiovascular anxiety, depression, cancer, chronic kidney failure, allergies, asthma order analyze impact health. Evidence suggests that carbohydrates, especially fiber, beneficial for well-being growth gut microorganisms consequently host symbiotic relationship, producing microbial alterations negative effect health different organic systems. In addition, evidence simple refined mood categories, including alertness tiredness, reinforcing vicious circle. Regarding sugar intake can affect prognosis uncontrolled puts individuals at risk developing syndrome subsequently disease.

Language: Английский

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The Role of Diet as a Modulator of the Inflammatory Process in the Neurological Diseases

Nutrients, Journal Year: 2023, Volume and Issue: 15(6), P. 1436 - 1436

Published: March 16, 2023

Neurological diseases are recognized as major causes of disability and mortality worldwide. Due to the dynamic progress such Alzheimer’s disease (AD), Parkinson’s Disease (PD), Schizophrenia, Depression, Multiple Sclerosis (MD), scientists mobilized look for new more effective methods interventions. A growing body evidence suggests that inflammatory processes an imbalance in composition function gut microbiome, which play a critical role pathogenesis various neurological dietary interventions, Mediterranean diet DASH diet, or ketogenic can have beneficial effects on their course. The aim this review was take closer at its ingredients modulating inflammation associated with development and/or progression central nervous system diseases. Presented data shows consuming abundant fruits, vegetables, nuts, herbs, spices, legumes sources anti-inflammatory elements omega-3 fatty acids, polyphenols, vitamins, essential minerals, probiotics while avoiding foods promote inflammation, create positive brain environment is reduced risk Personalized nutritional interventions may constitute non-invasive strategy combating disorders.

Language: Английский

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Underrated aspects of a true Mediterranean diet: understanding traditional features for worldwide application of a “Planeterranean” diet

Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: March 21, 2024

Abstract Over the last decades, Mediterranean diet gained enormous scientific, social, and commercial attention due to proven positive effects on health undeniable taste that facilitated a widespread popularity. Researchers have investigated role of Mediterranean-type dietary patterns human all around world, reporting consistent findings concerning its benefits. However, what does truly define diet? The myriad scores synthesizes nutritional content diet, but variety aspects are generally unexplored when studying adherence this pattern. Among factors, main characteristics such as consumption fruit vegetables, olive oil, cereals should be accompanied by other underrated features, following: (i) specific reference whole-grain consumption; (ii) considering legumes, nuts, seeds, herbs spices often untested exploring diet; (iii) eggs dairy products common foods consumed in region (irrespectively modern demonization fat intake). Another feature includes (red) wine consumption, more general alcohol intake unmeasured, lacking specificity drinking occasion intensity (i.e., during meals). aspects, cooking methods rather simple yet extremely varied. Several related quality food was first investigated: locally produced, minimally processed, preserved with natural fermentation), strongly connected territory limited controlled impact environment. Dietary habits also associated lifestyle behaviors, sleeping patterns, social cultural values, favoring commensality frugality. In conclusion, it is reductive consider just pattern groups decontextualized from geographical background culture. While methodologies study demonstrated useful up date, holistic approach considered future studies aforementioned features values potentially applied globally through concept “Planeterranean” diet.

Language: Английский

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Advances in Understanding the Interplay between Dietary Practices, Body Composition, and Sports Performance in Athletes

Nutrients, Journal Year: 2024, Volume and Issue: 16(4), P. 571 - 571

Published: Feb. 19, 2024

The dietary practices of athletes play a crucial role in shaping their body composition, influencing sports performance, training adaptations, and overall health. However, despite the widely acknowledged significance intake athletic success, there exists gap our understanding intricate relationships between nutrition, performance. Furthermore, emerging evidence suggests that many fail to adopt optimal nutritional practices, which can impede potential achievements. In response, this Special Issue seeks gather research papers delve into athletes’ impacts on composition Additionally, studies focusing interventions aimed at optimizing habits are encouraged. This paper outlines key aspects points will be developed ensuing articles Issue.

Language: Английский

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