Environmental Research,
Journal Year:
2023,
Volume and Issue:
243, P. 117776 - 117776
Published: Dec. 2, 2023
Exposure
to
metals
is
associated
with
increased
risk
of
type
2
diabetes
(T2D).
Potential
mechanisms
for
metals-T2D
associations
involve
biological
processes
including
oxidative
stress
and
disruption
insulin-regulated
glucose
uptake.
In
this
study,
we
assessed
whether
between
metal
exposure
metabolite
profiles
relate
pathways
linked
T2D.
We
used
data
from
29
adults
rural
Colorado
residents
enrolled
in
the
San
Luis
Valley
Diabetes
Study.
Urinary
concentrations
arsenic,
cadmium,
cobalt,
lead,
manganese,
tungsten
were
measured.
Metabolic
effects
evaluated
using
untargeted
metabolic
profiling,
which
included
61,851
signals
detected
serum.
cross-sectional
metabolites
present
at
least
50%
samples.
Primary
analyses
adjusted
urinary
heavy
creatinine.
Metabolite
outcomes
each
pathway
enrichment
investigate
potential
underlying
relationship
Participants
had
a
mean
age
58.5
years
(standard
deviation
=
9.2),
48.3%
female,
identified
as
Hispanic/Latino,
13.8%
current
smokers,
65.5%
Of
metabolites,
455
one
metal,
42
22
10
313
66
two
tungsten.
The
features
25
linoleate
metabolism,
butanoate
arginine
proline
metabolism.
Several
these
have
been
previously
T2D,
our
results
similar
when
only
participants
Our
support
hypothesis
that
may
be
related
amino
acid,
co-enzyme,
sugar
fatty
acid
Insight
into
could
influence
interventions
prevent
adverse
health
due
exposure.
Toxicology Reports,
Journal Year:
2023,
Volume and Issue:
10, P. 554 - 570
Published: Jan. 1, 2023
Increased
exposure
to
environmental
heavy
metals
and
metalloids
their
associated
toxicities
has
become
a
major
threat
human
health.
Hence,
the
association
of
these
with
chronic,
age-related
metabolic
disorders
gained
much
interest.
The
underlying
molecular
mechanisms
that
mediate
effects
are
often
complex
incompletely
understood.
In
this
review,
we
summarize
currently
known
disease-associated
signaling
pathways
altered
following
different
exposure,
alongside
brief
summary
impacts.
main
focus
study
is
explore
how
affected
chronic
multifactorial
diseases
including
diabetes,
cardiovascular
diseases,
cancer,
neurodegeneration,
inflammation,
allergic
responses
upon
arsenic
(As),
cadmium
(Cd),
chromium
(Cr),
iron
(Fe),
mercury
(Hg),
nickel
(Ni),
vanadium
(V).
Although
there
considerable
overlap
among
metalloids-affected
cellular
pathways,
affect
distinct
as
well.
common
may
be
explored
further
find
targets
for
treatment
pathologic
conditions.
BMC Public Health,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: April 29, 2024
Exposure
to
heavy
metals
alone
or
in
combination
can
promote
systemic
inflammation.
The
aim
of
this
study
was
investigate
potential
associations
between
multiple
plasma
and
markers
immune
Frontiers in Endocrinology,
Journal Year:
2022,
Volume and Issue:
13
Published: Aug. 15, 2022
Background
Pre-diabetes
precedes
Diabetes
Mellitus
(DM)
disease
and
is
a
critical
period
for
hyperglycemia
treatment,
especially
menopausal
women,
considering
all
metabolic
alterations
due
to
hormonal
changes.
Recently,
the
literature
has
demonstrated
role
of
physical
exercise
in
epigenetic
reprogramming
modulate
gene
expression
patterns
conditions,
such
as
hyperglycemia,
prevent
DM
development.
In
present
study,
we
hypothesized
that
training
could
modify
women
with
poor
glycemic
control.
Methods
48
post-menopause
aged
60.3
±
4.5
years
were
divided
according
their
fasting
blood
glucose
levels
into
two
groups:
Prediabetes
Group,
PG
(n=24),
Normal
Glucose
NGG
(n=24).
All
participants
performed
14
weeks
three
times
week.
The
Infinium
Methylation
EPIC
BeadChip
measured
participants’
Different
Methylated
Regions
(DMRs).
Results
Before
intervention,
group
had
12
DMRs
compared
NGG.
After
five
remained
different.
Interestingly,
when
comparing
before
after
training,
118
found.
enrichment
analysis
revealed
genes
related
different
biological
functions
energy
metabolism,
cell
differentiation,
tumor
suppression.
Conclusion
Physical
relevant
alternative
treating
preventing
