Benefits of physical exercise through multivariate analysis in sedentary adults and elderly: An analysis of physical fitness, health and anthropometrics

Experimental Gerontology, Journal Year: 2025, Volume and Issue: 200, P. 112669 - 112669

Published: Jan. 5, 2025

This study employed multivariate analysis to investigate the effects of a 14-week multicomponent training program on sedentary adults and older populations, focusing improvements in physical fitness, health markers, anthropometric measures. The data included 376 participants aged 30 84 years who had been inactive for at least 3 months. Results showed that 71 above lower systolic blood pressure, height, body mass, elbow flexion extension, sitting standing up from chair, agility, 6-Minute Walk Test (6MWT), handgrip strength values compared younger age groups (p < 0.05). Initially, 6MWT was inversely correlated with measures positively tests, but after intervention, it remained only agility. Interestingly, extension strongly other fitness pre-intervention, these relationships weakened afterward. Agility became key intermediary variable analysis. Despite improvements, variables like mass waist circumference continued have strong relationship outcomes. Significant gains were observed 0.05), indicating aerobic strength. Multivariate hip circumference, chair stand test, strength, agility significantly influenced performance. Using analysis, we able highlight importance incorporating regular exercise into daily life promote active healthy aging. Furthermore, emerged as most significant intermediate intervention. insight suggests may be crucial overall health.

Language: Английский

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Exercise training modifies the whole blood DNA methylation profile in middle-aged and older women

Journal of Applied Physiology, Journal Year: 2023, Volume and Issue: 134(3), P. 610 - 621

Published: Jan. 26, 2023

This is a longitudinal single-arm clinical trial aimed to investigate whether exercise training would modify the whole blood methylation profile in healthy women. A total of 45 subjects were engaged an protocol during 14-wk follow up, consisting aerobic cardiorespiratory and muscle strength exercises. Subjects evaluated at baseline (PRE), after 7 wk (POST 7), 14 14). Functional primary outcomes included anthropometric, pressure, biochemical measurements, physical tests, global health assessments. Blood samples collected each time point determine using DNA array technique screening up 850k different sites. Exercise decreased pressure triglyceride levels enhanced performance, including upper- lower-body maximum strength. Moreover, improved markers quality life. In analysis, changed more than 800 Across these differentially methylated sites, we found that sites promoter region hypermethylated training, suggesting this hypermethylation process may affect transcription process. When inputting pathway several metabolic pathways, AMPK signaling, TGF-β insulin signaling. study demonstrates promotes robust change provides new insights into key regulators exercise-induced benefits.NEW & NOTEWORTHY We have shown lowers levels, improves life middle-aged elderly Regarding epigenetic data, noticed are training. emphasize addition, shows members among genes older

Language: Английский

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Comparing Fourteen Weeks of Multicomponent Training Versus Combined Training in Physically Inactive Older Women: A Randomized Trial

International Journal of Environmental Research and Public Health, Journal Year: 2023, Volume and Issue: 20(3), P. 2699 - 2699

Published: Feb. 2, 2023

Combined (CT) and multicomponent training (MT) presents several benefits for aging individuals. However, the literature does not provide evidence on which of two physical models can better enhance improvements in capacity health parameters middle-aged older women.The aim this study was to compare effects MT CT capacity, cognitive, behavioral, psychosocial assessment, biochemical profile physically inactive women aged between 50 70 years.Participants were randomized into groups: (32 women, 64.2 ± 6.4 years) (39 61.4 4.3 years). Both sessions had a weekly volume 180 min, 14 weeks, with assessments at baseline after period.CT showed results when compared MT. In four evaluation blocks, we noticed differences effect size (L = large, M moderate, S small, T trivial) groups 26 variables total, highlighting group 11, 5, 2, 8) 8, 7, 4). Our findings group-time strength using maximum dynamic repetition test upper lower limbs agility. The improvement functional evaluated through elbow flexion extension (p 0.037), HDL 0.022).Fourteen weeks

Language: Английский

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Map of epigenetic age acceleration: a worldwide analysis

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102418 - 102418

Published: July 14, 2024

Language: Английский

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SLC25A19 is a novel prognostic biomarker related to immune invasion and ferroptosis in HCC

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 136, P. 112367 - 112367

Published: May 31, 2024

SLC25A19 is a mitochondrial thiamine pyrophosphate (TPP) carrier that mediates TPP entry into the mitochondria. has been recognized to play crucial role in many metabolic diseases, but its cancer not clearly reported. Based on clinical data from The Cancer Genome Atlas (TCGA), following parameters were analyzed among HCC patients: expression, enrichment analyses, immune infiltration, ferroptosis and prognosis analyses. In vitro, high expression was validated by qRT-PCR Immunohistochemistry. Subsequently, series of cell function experiments, including CCK8, EdU, clone formation, trans-well scratch assays, conducted illustrate effect growth metastasis cells. Meanwhile, indicators related also detected. SCL25A19 highly expressed predicts poor prognosis. Elevated patients markedly associated with T stage, pathological status (PS), tumor (TS), histologic grade (HG), AFP. Our results indicate generally good predictive diagnostic ability. gene analyses showed significantly correlated fatty acid metabolism, marker genes. vitro experiments have confirmed silencing can inhibit proliferation migration ability cells induce HCC. conclusion, these findings novel prognostic biomarker invasion HCC, it an excellent candidate for therapeutic target against

Language: Английский

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Delving Into the Interaction Between Exercise and Diabetes on Methylation of the FKBP5 Gene

Journal of Diabetes Research, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Objective: FKBP5 is a critical gene involved in regulating the hypothalamic-pituitary-adrenal (HPA) axis and stress response. Aberrant DNA methylation at cytosine-phosphate-guanine (CpG) sites, such as cg22363520 cg00862770, has been implicated mental health disorders metabolic diseases, including Type 2 diabetes. Exercise modulator of health. This study investigates interaction between exercise, diabetes, cg00862770 explores their implications for disease development. Materials Methods: levels were analyzed cohort stratified by diabetes exercise. Multiple linear regression models assessed main effects interactions exercise on methylation, with further analyses site-specific effects. Results: showed significant cg00862770. At cg22363520, significantly reduced nondiabetic participants (β = -0.00195, p 0.0157), while no effect was observed diabetic individuals. Conversely, decreased -0.00611, 0.0081), group. Diabetes itself associated increased both particularly individuals without regular Additionally, identified (p 0.0336) 0.0021), highlighting interplay status physical activity methylation. Conclusion: demonstrates that are influenced status. reduces nondiabetics diabetics, indicating its role modulating epigenetic regulation pathways. These findings underscore potential improving outcomes.

Language: Английский

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Map of epigenetic age acceleration: a worldwide meta-analysis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: March 17, 2024

Abstract This study is the first systematic meta-analysis of epigenetic age acceleration largest publicly available DNA methylation data for healthy samples (93 datasets, 23K samples), focusing on geographic and ethnic aspects different countries (25 countries) populations (31 ethnicities) around world. The most popular tools assessing were examined in detail, their quality metrics analyzed, ability to extrapolate from tissue types ranges training these models was explored. In cases, are not consistent with each other show signs acceleration, PhenoAge model tending systematically underestimate versions GrimAge overestimate prediction subjects. Although GEO open-access database, represented, datasets use criteria determining controls. Because this, it difficult fully isolate contribution “geography/environment”, “ethnicity” “healthiness” acceleration. However, DunedinPACE metric, which measures aging rate, adequately reflects standard living socioeconomic indicators countries, although can be applied only blood data. When comparing males faster than females considered.

Language: Английский

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Eight Weeks of Physical Training Decreases 2 Years of DNA Methylation Age of Sedentary Women

Research Quarterly for Exercise and Sport, Journal Year: 2023, Volume and Issue: 95(2), P. 405 - 415

Published: July 19, 2023

Purpose: The acceleration of epigenetic age is a predictor mortality and contributes to the increase in chronic diseases. Adherence healthy lifestyle strategy reduce age. present study aimed determine whether eight weeks combined (aerobic strength) training (CT) can influence women between 50 70 years old differences sites methylated regions. Methods: Eighteen (AARLow: lower residual, n = 10; AARHigh: higher 8) participated exercise program (60 minutes, 3× week) for weeks. DNA was extracted from whole blood using salting out technique. methylation performed array technique (Illumina's Infinium Methylation BeadChip 850k). We used Age Calculator platform calculate biological Two-way ANOVA followed by FISHER LSD posthoc Applied, adopting p < .05. Results: After CT, there were no changes AARLow group (PRE: -2.3 ± 3.2 POST: 3.6). However, AARHigh significantly decreased 3.6 2.6 2.2 2.7) (group effect, .01; time .31; vs. .005). Conclusion: CT benefits clock with most accelerated

Language: Английский

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The Heterogeneity of Post-Menopausal Disease Risk: Could the Basis for Why Only Subsets of Females Are Affected Be Due to a Reversible Epigenetic Modification System Associated with Puberty, Menstrual Cycles, Pregnancy and Lactation, and, Ultimately, Menopause?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(7), P. 3866 - 3866

Published: March 30, 2024

For much of human evolution, the average lifespan was <40 years, due in part to disease, infant mortality, predators, food insecurity, and, for females, complications childbirth. Thus, many females did not reach age menopause (45–50 years age) and it is mainly past several hundred that has been extended >75 primarily public health advances, medical interventions, antibiotics, nutrition. Therefore, underlying biological mechanisms responsible disease risk following must have evolved during complex processes leading Homo sapiens serve functions pre-menopausal state. Furthermore, as a primary function survival species effective reproduction, likely most advantages having such post-menopausal risks relate reproduction ability address environmental stresses. This opinion/perspective will be discussed context how could enhance with improved offspring, perhaps why are preserved. Not all exhibit this set diseases, those who do develop diseases conditions. The state operate unified complex, but independent variables, potential some overlap. there would heterogeneity if factors essential reproductive also concept sets reversible epigenetic changes associated puberty, pregnancy, lactation offered explain observations regarding distribution conditions their roles reproduction. While involvement an system dynamic “modification-demodification-remodification” paradigm contributing hypothesis at point, validation lead better understanding commonalities may future interventions control after menopause.

Language: Английский

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Serum Cobalt Concentration and DNA Methylation Signatures in Women with Obesity

Obesities, Journal Year: 2024, Volume and Issue: 4(2), P. 85 - 92

Published: April 27, 2024

Obesity, a multifactorial disorder, has been associated with alterations in metal metabolismand epigenetic modifications. This pilot case–control study aimed to investigate serum cobalt concentrations and DNA methylation patterns women obesity. Serum levels were measured using inductively coupled plasma mass spectrometry (ICP-MS), revealing significantly higher participants normal weight than Additionally, analysis identified differentially methylated positions (DMPs) exposure, DMPs between groups highlighted hypomethylation the top individuals Functional enrichment of these unveiled potential pathways implicated apoptosis, cancer, metabolic signaling, warranting further investigation into mechanistic links. provides preliminary insights interplay methylation, implications for obesity management.

Language: Английский

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