Effects of thiacloprid exposure on microbiota–gut–liver axis: Multiomics mechanistic analysis in Japanese quails

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130082 - 130082

Published: Sept. 30, 2022

Language: Английский

---

Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways

Phytomedicine, Journal Year: 2023, Volume and Issue: 116, P. 154899 - 154899

Published: May 23, 2023

Language: Английский

---

Overview of deltamethrin residues and toxic effects in the global environment

Environmental Geochemistry and Health, Journal Year: 2024, Volume and Issue: 46(8)

Published: July 2, 2024

Language: Английский

---

Deltamethrin induces apoptosis in cerebrum neurons of quail via promoting endoplasmic reticulum stress and mitochondrial dysfunction

Environmental Toxicology, Journal Year: 2022, Volume and Issue: 37(8), P. 2033 - 2043

Published: April 21, 2022

Deltamethrin (DLM) is a widely used and highly effective insecticide. DLM exposure harmful to animal human. Quail, as bird model, has been in the field of toxicology. However, there little information available literature about quail cerebrum damage caused by DLM. Here, we investigated effect on neurons. Four groups healthy quails were assigned (10 each group), respectively given 0, 15, 30, 45 mg/kg gavage for 12 weeks. Through measurements cerebrum, it was found that induced obvious histological changes, oxidative stress, neurons apoptosis. To further explore possible molecular mechanisms, performed real-time quantitative PCR detect expression endoplasmic reticulum (ER) stress-related mRNA such glucose regulated protein 78 kD, activating transcription factor 6, inositol requiring enzyme, kinase RNA (PKR)-like ER kinase. In addition, detected ATP content evaluate functional status mitochondria. The study showed significantly increased decreased tissues. These results suggest chronic induces apoptosis via promoting stress mitochondrial dysfunction. Furthermore, our provide novel explanation DLM-induced avian

Language: Английский

---

Chronic exposure to deltamethrin disrupts intestinal health and intestinal microbiota in juvenile crucian carp

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 241, P. 113732 - 113732

Published: June 6, 2022

The indiscriminate use of deltamethrin in agriculture and aquaculture can lead to residues increased many regions, which poses negative impacts on intestinal health aquatic organisms. Although the potential toxicity have recently attracted attention, comprehensive studies injuries after chronic exposure remain poorly understood. Herein, a 28-day test, crucian carp expose different concentrations (0, 0.3, 0.6 μg/L) were used as research object. We found that morphology changes goblet cells tissue, extent tissue injury along with increasing dose deltamethrin. Additionally, genes expression antioxidant activity (Cu/Zn superoxide dismutase (Cu-Zn SOD), glutathione peroxidase 1 (GPX1), catalase (CAT)), inflammatory response (tumor necrosis factor alpha (TNFα), interferon gamma (IFNγ), interleukin beta (IL-1β)), tight junctions (Claudin 12 (CLDN12), junction protein (ZO-1)) dramatically increased. Meanwhile, apoptosis autophagy process triggered through caspase-9 cascade related 5 (ATG5)- (ATG12) conjugate. Besides, amount Proteobacteria Verrucomicrobiota, while decreased Fusobacteriota abundance, resulting microbiota function disorders. In summary, our results highlight cause serious physiological flora disturbances.

Language: Английский

---

Contribution of Immune Responses to the Cardiotoxicity and Hepatotoxicity of Deltamethrin in Early Life Stage Zebrafish (Danio rerio)

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(22), P. 9515 - 9524

Published: April 30, 2024

Deltamethrin (DM) is a widely used insecticide that has demonstrated developmental toxicity in the early life stages of fish. To better characterize underlying mechanisms, embryos from Tg(cmlc2:RFP), Tg(apo14:GFP), and Tg(mpx:GFP) transgenic strains zebrafish were exposed to nominal DM concentrations 0.1, 1, 10, 25, 50 μg/L until 120 h post-fertilization (hpf). Heart size increased 56.7%, liver was reduced by 17.1% 22.7 24.2 DM, respectively. RNA sequencing bioinformatic analyses predicted key biological processes affected exposure related inflammatory responses. Expression IL-1 protein 69.0% 24.4 treatment, aggregation neutrophils cardiac hepatic histologic sections also observed. Coexposure resatorvid, an anti-inflammatory agent, mitigated responses induced restored biomass. Our data indicated complex proinflammatory mechanism DM-induced cardiotoxicity hepatotoxicity which may be important for events adverse outcomes associated risks

Language: Английский

---

Coenzyme Q10, Biochanin A and Phloretin Attenuate Cr(VI)-Induced Oxidative Stress and DNA Damage by Stimulating Nrf2/HO-1 Pathway in the Experimental Model

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(5), P. 2427 - 2441

Published: Aug. 12, 2022

Language: Английский

---

Rhein Exhibits Anti-Inflammatory Effects in Chronic Atrophic Gastritis via Nrf2 and MAPK Signaling

The Turkish Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: unknown

Published: Feb. 13, 2023

Chronic atrophic gastritis is a premalignant lesion with high risk of developing into gastric cancer. Rhein key active ingredient several traditional Chinese medicines multiple pharmacological effects. Nevertheless, the role rhein in chronic unclear.Helicobacter pylori infection was used to establish mouse model. Murine mucosa treated saline or experiments. Hematoxylin and eosin staining Alcian blue-periodic acid-Schiff were utilized for histopathological observation murine mucosa. The levels proinflammatory factors detected by enzyme-linked immunosorbent assay, oxidative stress-associated markers commercially available assay kits. Western blotting measuring nuclear factor, erythroid 2-like bZIP transcription factor 2, mitogen-activated protein kinase signaling-related proteins.Rhein mitigated mucosal injury suppressed inflammation stress H. pylori-infected models. inactivated activated 2 signaling mice gastritis.Rhein exhibits anti-inflammatory antioxidant effects via signaling.

Language: Английский

---

Sulforaphane, an NRF2 agonist, alleviates ferroptosis in acute liver failure by regulating HDAC6 activity

Journal of Integrative Medicine, Journal Year: 2023, Volume and Issue: 21(5), P. 464 - 473

Published: Aug. 9, 2023

Language: Английский

---

Occurrence, sources, and risk assessment of pyrethroid insecticides in surface water and tap water from Taihu Lake, China

Journal of Environmental Management, Journal Year: 2022, Volume and Issue: 325, P. 116565 - 116565

Published: Oct. 22, 2022

Language: Английский

---