The emerging role of microplastics in systemic toxicity: Involvement of reactive oxygen species (ROS)

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 895, P. 165076 - 165076

Published: June 28, 2023

Language: Английский

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Health risk of human exposure to microplastics: a review

Environmental Chemistry Letters, Journal Year: 2024, Volume and Issue: 22(3), P. 1155 - 1183

Published: March 25, 2024

Language: Английский

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Co-exposure to environmentally relevant concentrations of cadmium and polystyrene nanoplastics induced oxidative stress, ferroptosis and excessive mitophagy in mice kidney

Environmental Pollution, Journal Year: 2023, Volume and Issue: 333, P. 121947 - 121947

Published: June 1, 2023

Language: Английский

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Microplastic-mediated new mechanism of liver damage: From the perspective of the gut-liver axis

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 919, P. 170962 - 170962

Published: Feb. 13, 2024

Language: Английский

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The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108736 - 108736

Published: May 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Language: Английский

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Polystyrene nanoparticle exposure supports ROS-NLRP3 axis-dependent DNA-NET to promote liver inflammation

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 439, P. 129502 - 129502

Published: July 3, 2022

Language: Английский

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Nanoplastics Toxicity Specific to Liver in Inducing Metabolic Dysfunction—A Comprehensive Review

Genes, Journal Year: 2023, Volume and Issue: 14(3), P. 590 - 590

Published: Feb. 26, 2023

Plastic pollution in the world is widespread and growing. The environment swamped with nanoplastics (<100 nm), health consequences of these less visible pollutants are unknown. Furthermore, there evidence that microplastics can release by digestive disintegration, implying macroplastic exposure cause direct indirect disease via nanoplastics. existence impact numerous tissues from invertebrates to larger vertebrates consume significant amounts plastics were investigated, histopathological techniques utilized determine physiological reactions inflammation plastics. Nanoplastics enters an organism through respiratory gastro-intestinal tract where they accumulate into liver blood circulation absorption, or epidermal infiltration. It stated macroplastics damage directly at site exposure, whereas influence liver, causing subsequent other organs. Multi-organ dysfunction brought on changes, readily enter gut-liver axis disturb gut microflora. By exploring literature summarizing research has been published date, this review article reveals deleterious effect mechanisms pathophysiological functions hepatic system.

Language: Английский

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Journey of micronanoplastics with blood components

RSC Advances, Journal Year: 2023, Volume and Issue: 13(45), P. 31435 - 31459

Published: Jan. 1, 2023

Micronanoplastics (MNPs) interact with blood components, resulting in anemia, cardiovascular diseases, etc. Research gaps include toxic impacts of real-world MNPs, monomers, co-pollutants complex, and so on, emphasizing the need for more research.

Language: Английский

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Combinational exposure to hydroxyatrazine increases neurotoxicity of polystyrene nanoparticles on Caenorhabditis elegans

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 880, P. 163283 - 163283

Published: April 4, 2023

Language: Английский

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Combined Effects of Polystyrene Nanosphere and Homosolate Exposures on Estrogenic End Points in MCF-7 Cells and Zebrafish

Environmental Health Perspectives, Journal Year: 2024, Volume and Issue: 132(2)

Published: Feb. 1, 2024

Micro- and nanoplastics (MNPs) homosalate (HMS) are ubiquitous emerging environmental contaminants detected in human samples. Despite the well-established endocrine-disrupting effects (EDEs) of HMS, interaction between MNPs HMS its impact on HMS-induced EDEs remain unclear.

Language: Английский

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