Perfluorooctane sulfonate causes pyroptosis and lipid metabolism disorders through ROS-mediated NLRP3 inflammasome activation in grass carp hepatocyte

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 267, P. 106839 - 106839

Published: Jan. 15, 2024

Language: Английский

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Co-exposure of arsenic and polystyrene-nanoplastics induced kidney injury by disrupting mitochondrial homeostasis and mtROS-mediated ferritinophagy and ferroptosis

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 201, P. 105904 - 105904

Published: April 10, 2024

Language: Английский

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The impact of nanomaterials on autophagy across health and disease conditions

Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)

Published: April 17, 2024

Abstract Autophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as defense response becomes particularly evident upon exposure nanomaterials (NMs), especially environmental nanoparticles (NPs) nanoplastics (nPs). This has positioned modulation at the forefront nanotechnology-based therapeutic interventions. While NMs can exploit enhance outcomes, they also trigger it pro-survival against NP-induced toxicity. Conversely, heightened may lead regulated cell death (RCD), in particular autophagic death, NP exposure. Thus, relationship between exhibits dual nature with Recognizing decoding these intricate patterns are essential for pioneering next-generation autophagy-regulating NMs. review delves into present-day potential autophagy-modulating NMs, shedding light on their status clinical trials, intervention applications discusses potency application early indicator NM Graphical

Language: Английский

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Microplastics induced endoplasmic reticulum stress to format an inflammation and cell death in hepatocytes of carp (Cyprinus carpio)

Aquatic Toxicology, Journal Year: 2024, Volume and Issue: 269, P. 106870 - 106870

Published: Feb. 19, 2024

Language: Английский

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The size-dependence and reversibility of polystyrene nanoplastics-induced lipid accumulation in mice: Possible roles of lysosomes

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108532 - 108532

Published: Feb. 24, 2024

Nanoplastics (NPs) continue to accumulate in global aquatic and terrestrial systems, posing a potential threat human health through the food chain and/or other pathways. Both vivo vitro studies have confirmed that liver is one of main organs targeted for accumulation NPs living organisms. However, whether exposure induces size-dependent disorders lipid metabolism remains controversial, reversibility NPs-induced hepatotoxicity largely unknown. In this study, effects long-term environmentally relevant doses polystyrene nanoplastics (PS-NPs) on were investigated terms autophagy lysosomal mechanisms. The findings indicated hepatic was more pronounced mice exposed 100 nm PS-NPs compared 500 PS-NPs. This effect effectively alleviated after 50 days self-recovery exposure. Mechanistically, although activated autophagosome formation ERK (mitogen-activated protein kinase 1)/mTOR (mechanistic target rapamycin kinase) signaling pathway, inhibition Rab7 (RAB7, member RAS oncogene family), CTSB (cathepsin B), CTSD D) expression impaired function, thereby blocking autophagic flux contributing accumulation. After termination exposure, exocytosis responsible clearance accumulated lysosomes. Furthermore, function alleviated. might be reason alleviation PS-NPs-induced recovery. Collectively, we demonstrate first time lysosomes play dual role persistence induced by environmental NPs, which provide novel evidence prevention intervention injury associated with

Language: Английский

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Co-exposure to polystyrene nanoplastics and F-53B induces vascular endothelial cell pyroptosis through the NF-κB/NLRP3 pathway

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 486, P. 137114 - 137114

Published: Jan. 5, 2025

Language: Английский

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CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 6, 2025

Cadmium (Cd) and polystyrene microplastics (PS-MPs), two ubiquitous environmental contaminants, produce unique synergistic toxicity when co-existing. Key unanswered questions include specific effects on liver function potential mechanisms. In this study, C57BL/6 mice AML12 cells were used to establish in vivo vitro models elucidate the of combined exposure PS-MPs Cd their The results showed that caused significantly more damage than alone. As observed by transmission electron microscopy (TEM), number autophagosomes was increased co-treated group. addition, autophagic flux assayed RFP-GFP-LC3, a reporter system expressing dual fluorescent proteins, which an overwhelming enhancement co-exposure compared To further investigate involvement carnitine palmitoyltransferase1(CPT1) injury induced PS-MPs, we co-exposed Baicalin, activator CPT1, with Cd, activation CPT1 alleviated impairment fluxes changes lipid accumulation associated protein levels. conclusion, concurrent resulted blockage hepatic pathway aggravated toxic liver. Activation could alleviate Cd-induced autophagy thus reducing injury.

Language: Английский

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Inducers of Autophagy and Cell Death: Focus on Copper Metabolism

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117725 - 117725

Published: Jan. 1, 2025

Language: Английский

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Exposure to polystyrene nanoplastics induces an anxiolytic-like effect, changes in antipredator defensive response, and DNA damage in Swiss mice

Journal of Hazardous Materials, Journal Year: 2022, Volume and Issue: 442, P. 130004 - 130004

Published: Sept. 16, 2022

Language: Английский

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Whole transcriptome sequencing analysis revealed key RNA profiles and toxicity in mice after chronic exposure to microplastics

Chemosphere, Journal Year: 2022, Volume and Issue: 304, P. 135321 - 135321

Published: June 16, 2022

Language: Английский

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