Combined toxicity of micro/nanoplastics loaded with environmental pollutants to organisms and cells: Role, effects, and mechanism

Environment International, Journal Year: 2022, Volume and Issue: 171, P. 107711 - 107711

Published: Dec. 21, 2022

Micro/nanoplastics (MPs/NPs) are ubiquitous in the environment and living organisms have been exposed to these substances for a long time. When MPs/NPs enter different organisms, they transport various pollutants, including heavy metals, persistent organic drugs, bacteria, viruses, from environment. On this basis, paper summarizes combined toxicity induced by accumulating contaminants entering through systematic review of 162 articles. Moreover, factors influencing toxic interactions critically discussed, thus highlighting dominant role relative concentrations effects. Furthermore, first time, we describe threats posed with other pollutants human health, as well their cytotoxic behavior mechanism. We found that "Trojan horse" effect nanoplastics can increase bioaccessibility environmental increasing carcinogenic risk humans. Simultaneously, complex cells observed be constantly dissociated due lysosomes. However, current research on intracellular release MP/NP-loaded is relatively poor, which hinders accurate vivo assessment pollutants. Based findings our critical review, recommend analyzing effects clarifying dose relationship each component pollutant cells, challenging yet crucial exploring mechanism pollution. In future, contribute establishing system modeling complete load-translocation toxicological MP/NP-based composite

Language: Английский

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Are Microplastics Toxic? A Review from Eco-Toxicity to Effects on the Gut Microbiota

Metabolites, Journal Year: 2023, Volume and Issue: 13(6), P. 739 - 739

Published: June 9, 2023

Emerging studies have presented an initial picture of the toxic effects exposure to environmental micro- and nanoplastics. They indicated that nanoplastics may induce toxicity by leading oxidative stress, energy metabolism disorders, gene damage, so forth in organisms, marine invertebrates vertebrates, laboratory mouse models. In recent years, been discovered human fecal samples, placentas, lung tissue, even blood; thus, pose alarming ever-increasing threat global public health. However, current research on health possible adverse outcomes humans has only tip iceberg. More robust clinical data basic experiments are still warranted elucidate specific relationships mechanisms. this paper, we review nanoplastic from perspectives eco-toxicity, impact gut microbiota its metabolites. addition, evaluate toxicological role potential implications respect We also summarize regarding preventive strategies. Overall, provides insights underlying mechanisms, opening up scientific avenues for future in-depth studies.

Language: Английский

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The effects of Micro/Nano-plastics exposure on plants and their toxic mechanisms: A review from multi-omics perspectives

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 465, P. 133279 - 133279

Published: Dec. 19, 2023

Language: Английский

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Nanoplastic-protein corona interactions and their biological effects: A review of recent advances and trends

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 166, P. 117206 - 117206

Published: July 24, 2023

Language: Английский

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Unveiling the mechanism of micro-and-nano plastic phytotoxicity on terrestrial plants: A comprehensive review of omics approaches

Environment International, Journal Year: 2025, Volume and Issue: 195, P. 109257 - 109257

Published: Jan. 1, 2025

Micro-and-nano plastics (MNPs) are pervasive in terrestrial ecosystems and represent an increasing threat to plant health; however, the mechanisms underlying their phytotoxicity remain inadequately understood. MNPs can infiltrate plants through roots or leaves, causing a range of toxic effects, including inhibiting water nutrient uptake, reducing seed germination rates, impeding photosynthesis, resulting oxidative damage within system. The effects complex influenced by various factors size, shape, functional groups, concentration. Recent advancements omics technologies such as proteomics, metabolomics, transcriptomics, microbiomics, coupled with emerging like 4D omics, phenomics, spatial single-cell offer unprecedented insight into physiological, molecular, cellular responses exposure. This literature review synthesizes current findings regarding MNPs-induced phytotoxicity, emphasizing alterations gene expression, protein synthesis, metabolic pathways, physiological disruptions revealed analyses. We summarize how interact structures, disrupt processes, induce stress, ultimately affecting growth productivity. Furthermore, we have identified critical knowledge gaps proposed future research directions, highlighting necessity for integrative studies elucidate pathways toxicity plants. In conclusion, this underscores potential approaches MNPs-phytotoxicity develop strategies mitigating environmental impact on health.

Language: Английский

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Genotoxic and neurotoxic potential of intracellular nanoplastics: A review

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(11), P. 1657 - 1678

Published: March 17, 2024

Abstract Plastic waste comprises polymers of different chemicals that disintegrate into nanoplastic particles (NPLs) 1–100‐nm size, thereby littering the environment and posing a threat to wildlife human health. Research on NPL contamination has up now focused ecotoxicology effects pollution rather than health risks. This review aimed speculate about possible properties carcinogenic neurotoxic as pollutants. Given their low‐dimensional size high surface ratio, NPLs can easily penetrate biological membranes cause functional structural damage in cells. Once inside cell, interrupt autophagy flux cellular debris, alter proteostasis, provoke mitochondrial dysfunctions, induce endoplasmic reticulum stress. Harmful metabolic processes induced by include oxidative stress (OS), ROS generation, pro‐inflammatory reactions. Depending cell cycle status, may direct DNA damage, tumorigenesis, lately carcinogenesis tissues with self‐renewal capabilities like epithelia. In cells able live longest neurons, could trigger neurodegeneration promoting toxic proteinaceous aggregates, OS, chronic inflammation. genotoxicity neurotoxicity are discussed based gathered evidence, when available, within context intracellular uptake these newcomer nanoparticles. summary, this explains how risk evaluation for benefit from accurately monitoring toxicokinetics toxicodynamics at resolution level.

Language: Английский

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Polystyrene nanoplastics synergistically exacerbate diclofenac toxicity in embryonic development and the health of adult zebrafish

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2024, Volume and Issue: 281, P. 109926 - 109926

Published: April 17, 2024

Language: Английский

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Spectroscopic investigations on the interaction between nano plastic and catalase on molecular level

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 863, P. 160903 - 160903

Published: Dec. 13, 2022

Language: Английский

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The combined effects of polystyrene nanoplastics with nickel on oxidative stress and related toxic effects to earthworms from individual and cellular perspectives

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 912, P. 168819 - 168819

Published: Dec. 1, 2023

Language: Английский

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Toxicological Response of Zebrafish Exposed to Cocktails of Polymeric Materials and Valproic Acid

Sustainability, Journal Year: 2024, Volume and Issue: 16(5), P. 2057 - 2057

Published: March 1, 2024

Microplastic pollution represents an emerging problem of great interest in the public domain last decade; addition, it overlaps with another delicate problem—pollution pharmaceutical products that can have negative effects on environment and people, even small amounts. The main purpose this study was to assess biochemical behavioral exposure adult zebrafish (Danio rerio) polyethylene (PE), polypropylene (PP) valproic acid (VPA), respectively their mixtures—possible situations natural aquatic environments. In terms responses, sociability appears be more impaired PP group after 5 days exposure. mechanisms affected are those swimming performance than sociability. Even more, VPA increases presence arm conspecifics but decreases mobility locomotion, indicating a possible anxiety mechanism. mixtures decrease aggressiveness, especially case PE+VPA group, where reaches super low level compared control, which could endanger species nature. Regarding anxiogenic effect, PE act differently: if has opposite side is shows bolder agitated behavior. All four variants showed changes indicative toxicity from first dose.

Language: Английский

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