Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 17, 2025
Perfluorinated
compounds
(PFAS)
are
well
recognized
toxic
pollutants
for
humans,
but
if
their
effect
is
equally
harmful
healthy
and
fragile
people
unknown.
Addressing
this
question
represents
a
need
ensuring
global
health
wellbeing
to
all
individuals
in
world
facing
the
progressive
increase
of
aging
related
diseases.
This
study
aimed
evaluate
impact
perfluorooctane
sulfonate
(PFOS),
perfluorooctanoic
acid
(PFOA)
perfluorohexanoic
(PFHxA)
exposure
on
development
skeletal
phenotype
using
osteogenesis
imperfecta
(OI)
zebrafish
model
Chihuahua
(Chi/+),
carrying
dominant
glycine
substitution
α1
chain
collagen
I
wild-type
(WT)
littermates.
To
purpose
Chi/+
WT
expressing
green
fluorescent
protein
under
early
osteoblast
marker
osterix
were
exposed
from
1
6
days
post
fertilization
0.36,
1.5
3.0
mg/L
PFOS,
0.005
0.5
PFOA
0.01,
0.48
16.0
PFHxA,
investigated.
Morphometric
measurements,
confocal
microscopy
evaluation
operculum
area
delimited
by
preosteoblasts
mineral
deposition
analysis
following
alizarin
red
staining
employed.
PFOS
highest
concentration
PFHxA
significantly
impaired
standard
length
both
genotypes.
Osteoblast
differentiation
was
compromised
only
Chi/+.
Limited
reduced
mineralization
also
observed.
No
detected
after
exposure.
Apoptosis
activated
PFOA,
specifically
mutant
osteoblasts.
Interestingly,
an
altered
lipid
distribution
fish
revealed
pollutants.
In
conclusion,
our
data
demonstrate
that
PFAS
impair
mainly
compromising
cell
whereas
alter
hepatic
genotypes
with
more
severe
preosteoblast
survival.
These
results
represent
first
warning
sign
negative
presence
genetically
determined
fragility.
Environment International,
Journal Year:
2023,
Volume and Issue:
172, P. 107795 - 107795
Published: Feb. 1, 2023
Perfluoroalkyl
acids
(PFAAs)
are
contaminants
of
global
concern,
and
the
inadvertent
consumption
PFAA-contaminated
crops
may
pose
a
threat
to
public
health.
Therefore,
systematically
studying
their
source
tracing,
bioaccumulation
prediction
risk
assessments
in
is
an
urgent
priority.
This
study
investigated
apportionment
transport
PFAAs
novel
fluorinated
alternatives
(collectively
as
per-
polyfluoroalkyl
substances,
PFASs)
from
factories
agricultural
fields
fluorochemical
industrial
region
China.
Furthermore,
specificities
these
chemicals
different
vegetables
were
explored,
followed
by
comprehensive
assessment
dinner
plates
which
considered
precursor
degradation.
A
positive
matrix
factorization
model
revealed
that
approximately
70
%
PFASs
soils
derived
manufacturing
metal
processing.
Alarming
levels
∑PFASs
ranged
8.28–84.3
ng/g
163–7176
vegetables.
PFAS
with
short
carbon
chain
or
carboxylic
acid
group
well
branched
isomers
exhibited
higher
environmental
potentials
factors
(BAFs)
across
range
The
BAFs
perfluorooctanoic
(PFOA)
decreased
perfluoromethyl
moved
further
functional
group.
Hexafluoropropylene
oxide
dimer
(GenX)
showed
relatively
low
BAFs,
probably
related
its
ether
bond
high
affinity
soil.
Vegetables
fewer
Casparian
strips
(e.g.,
carrot
radish),
more
protein,
possessed
larger
PFASs.
equation
integrating
critical
parameters
PFASs,
soils,
was
built
corroborated
good
contamination
prediction.
After
total
oxidizable
precursors
(TOP)
assay,
incremental
perfluoroalkyl
(PFCAs)
massively
found
(325–5940
ng/g)
edible
vegetable
parts.
Besides,
degradation
volatilization
loss
firstly
confirmed
during
cooking.
based
on
TOP
assay
developed
assist
protection
consumers.
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
57(40), P. 14904 - 14916
Published: Sept. 29, 2023
Current
toxicological
data
of
perfluoroalkyl
acids
(PFAAs)
are
disparate
under
similar
exposure
scenarios.
To
find
the
cause
conflicting
data,
this
study
examined
influence
chemical
speciation
on
toxicity
representative
PFAAs,
including
perfluorooctanoic
acid
(PFOA),
perfluorobutane
carboxylic
(PFBA),
and
perfluorobutanesulfonic
(PFBS).
Zebrafish
embryos
were
acutely
exposed
to
PFAA,
PFAA
salt,
a
pH-negative
control,
after
which
developmental
impairment
mechanisms
explored.
The
results
showed
that
PFAAs
generally
more
toxic
than
corresponding
pH
indicating
embryonic
was
mainly
caused
by
pollutants
themselves.
In
contrast
high
salts
only
exhibited
mild
hazards
zebrafish
embryos.
Fingerprinting
changes
along
thyroidal
axis
demonstrated
distinct
modes
endocrine
disruption
for
salts.
Furthermore,
biolayer
interferometry
monitoring
found
PFOA
PFBS
bound
strongly
with
albumin
proteins
did
their
Accordingly,
accumulated
significantly
higher
concentrations
salt
counterparts.
present
findings
highlight
importance
forms
outcome
toxicity,
calling
discriminative
risk
assessment
management
Environmental Science & Technology,
Journal Year:
2023,
Volume and Issue:
58(2), P. 1287 - 1298
Published: Dec. 19, 2023
Despite
the
known
direct
toxicity
of
various
antibiotics
to
aquatic
organisms,
potential
chronic
impact
through
intergenerational
transmission
on
reproduction
remains
elusive.
Here,
we
exposed
zebrafish
a
mixture
15
commonly
consumed
at
environmentally
relevant
concentrations
(1
and
100
μg
L–1)
with
cross-mating
design.
A
high
accumulation
was
detected
in
ovary
(up
904.58
ng
g–1)
testis
1704.49
F0
fish.
The
from
generation
subsequent
(F1
offspring)
confirmed
rate
(ki)
ranging
0.11
2.32.
maternal
transfer
significantly
higher,
relative
paternal
transfer,
due
greater
role
ovarian
enrichment
oviposition
compared
enrichment.
There
were
similar
impairments
reproductive
developmental
indexes
F1
eggs
found
following
both
female
male
parental
exposure.
Almost
all
eliminated
F2
comparison
eggs.
However,
there
still
toxic
responses
observed
fish,
suggesting
that
antibiotic
concentration
levels
not
only
criterion
for
evaluating
effects
each
generation.
These
findings
unveil
mechanism
fish
models
underscore
their
lasting
environments.
