Occurrence and toxicity mechanisms of perfluorobutanoic acid (PFBA) and perfluorobutane sulfonic acid (PFBS) in fish

Chemosphere, Journal Year: 2023, Volume and Issue: 349, P. 140815 - 140815

Published: Nov. 29, 2023

Language: Английский

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Per- and polyfluoroalkyl substances and human health outcomes: An umbrella review of systematic reviews with meta-analyses of observational studies

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 472, P. 134556 - 134556

Published: May 8, 2024

Language: Английский

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GenX analogs exposure induced greater hepatotoxicity than GenX mainly via activation of PPARα pathway while caused hepatomegaly in the absence of PPARα in female mice

Environmental Pollution, Journal Year: 2024, Volume and Issue: 344, P. 123314 - 123314

Published: Jan. 11, 2024

Language: Английский

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Proteomic and cardiac dysregulation by representative perfluoroalkyl acids of different chemical speciation during early embryogenesis of zebrafish

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 926, P. 172000 - 172000

Published: March 27, 2024

Language: Английский

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Effects of long-chained perfluoroalkyl acids (PFAAs) on the uptake and bioaccumulation of short-chained PFAAs in two free-floating macrophytes: Eichhornia crassipes and Ceratophyllum demersum

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 474, P. 134778 - 134778

Published: May 31, 2024

Language: Английский

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Neurotoxicity and intestinal microbiota dysbiosis induced by per- and polyfluoroalkyl substances in crucian carp (Carassius auratus)

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 478, P. 135611 - 135611

Published: Aug. 23, 2024

Language: Английский

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Distinctively Different Effects of Perfluorobutanoic Acid and Perfluorononanoic Acid on Zebrafish Sex Differentiation and Androgen Receptor Activity

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Language: Английский

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The blockage of the electron transport chains caused by PFOA isomers induced metabolic damage of Arabidopsis leaves

Environmental Chemistry and Ecotoxicology, Journal Year: 2025, Volume and Issue: 7, P. 516 - 526

Published: Jan. 1, 2025

Language: Английский

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6:2 fluorotelomer sulfonate as a safer alternative to PFOS: Comparative cytotoxicity and oxidative stress mechanisms in pancreatic β-cells (INS-1 model)

Toxicology in Vitro, Journal Year: 2025, Volume and Issue: unknown, P. 106034 - 106034

Published: Feb. 1, 2025

Language: Английский

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Effects of Chemical Speciation on Chronic Thyroid Toxicity of Representative Perfluoroalkyl Acids

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 7, 2025

Acute exposure studies have reported that chemical speciation significantly affects the developmental toxicity of perfluoroalkyl acids (PFAAs). However, mechanisms underlying chronic PFAAs as a function remain unknown. With an aim to gain more insights into PFAA structure-toxicity relationship, this study exposed adult zebrafish and salts perfluorooctanoate (PFOA), perfluorobutanoate (PFBA), perfluorobutanesulfonate (PFBS) at environmentally realistic concentrations for 5 months. In F0 generation, induced hypothyroidism symptoms potently than their salt counterparts. After parental exposure, speciation-dependent transfer behavior was noted, with greater burden in offspring. Similarly, were associated higher risks transgenerational defects thyroid dysfunction during offspring embryogenesis. bound receptor beta (TRβ) strongly salts. An antagonistic interaction PFOA PFBS TR activity observed vitro via reduction TRβ accessibility target genes. CUT&Tag sequencing revealed disturbances due on genomic profile TRβ, indicating interfere multiple thyroidal nervous processes. conclusion, current findings provided evidence regarding critical effects toxicity, highlighting need perform discriminative risk assessment management.

Language: Английский

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