A systematic review for non-targeted analysis of per- and polyfluoroalkyl substances (PFAS)

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178240 - 178240

Published: Jan. 1, 2025

This review follows the PRISMA guidelines to provide a systematic of 115 peer reviewed articles that used non-targeted analysis (NTA) methods detect per- and polyfluoroalkylated substances (PFAS). literature highlights significant positive impact NTA in understanding PFAS environment. Within geographical bias exists, with most studies (∼60 %) conducted United States China. Future other regions (such as South America Africa) are needed gain more global understanding. More research is required marine environments atmosphere, current focus mainly on freshwater, groundwater, soil, sediments. The majority measuring environment, rather than commercial products (with exception AFFF). Non-lethal blood sampling has been successful for humans wildlife, but additional biomonitoring exposed cohorts understand health risks biotransformation pathways. mostly use liquid chromatography negative ionisation, which biases towards detection specific PFAS. Despite improvements data reporting quality assurance control (QA/QC) procedures, factors such false rates often overlooked, many workflows remain highly subjective. Perfluoroalkyl carboxylic acids (PFCAs) perfluoroalkyl sulfonic (PFSAs) detected classes, identified over 80 % studies, common routine monitoring. However, our >1000 from total 382 different 300 classes found fewer 5 studies. variety present limitations relying solely targeted methods. monitoring programs regulations would benefit considering comprehensive information

Language: Английский

---

Unveiling per- and polyfluoroalkyl substances contamination in e-cigarette refill liquids: A comprehensive analytical assessment

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 960, P. 178297 - 178297

Published: Jan. 1, 2025

Language: Английский

---

A critical review of perfluoroalkyl and polyfluoroalkyl substances (PFAS) landfill disposal in the United States

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 905, P. 167185 - 167185

Published: Sept. 19, 2023

Language: Английский

---

Unveiling per- and polyfluoroalkyl substance contamination in Chinese paper products and assessing their exposure risk

Environment International, Journal Year: 2024, Volume and Issue: 185, P. 108540 - 108540

Published: Feb. 28, 2024

The contamination characteristics, migration patterns and health risks of per- polyfluoroalkyl substances (PFAS) were investigated in 66 Chinese paper products by using target non-target screening methods. Among 57 PFASs, 5 6 PFASs found the hygiene (

Language: Английский

---

Analysis of per- and polyfluoroalkyl substances (PFAS) in raw materials intended for the production of paper-based food contact materials – evaluating LC-MS/MS versus total fluorine and extractable organic fluorine

Food Additives & Contaminants Part A, Journal Year: 2024, Volume and Issue: 41(5), P. 525 - 536

Published: March 26, 2024

Per- and polyfluoroalkyl substances (PFAS) analysis has become crucial due to their presence in the environment, persistence potential health risks. These compounds are commonly used food contact materials (FCM) as a coating provide water grease-repellent properties. One of pathways for PFAS enter human body is either through direct consumption contaminated or indirectly migration from FCM into food. The purpose this study was investigate where initial contamination paper occurs. We analysed material consisting fresh fibre secondary materials, intended produce packaging PFAS. samples were extracted 23 different using targeted approach with LC tandem mass spectrometry (LC-MS/MS). This analytical technique detects specific, easily ionisable high sensitivity. However, one drawback that it allows identification less than 1% known today. For reason, we combustion ion chromatography (CIC) determine content extractable organic fluorine (EOF) compare total content. LC-MS/MS measured an average sum concentration 0.17 ng g−1 sample. Our research shows primary happens during recycling process since all which belonged material. most frequently detected analytes PFOA PFOS, 90% 62% samples, respectively, followed by PFBS (in 29% samples). CIC showed via amount 2.7 × 10−4% content, whereas EOF under LOD samples. result highlights complexity accurate determination compounds, displaying what kind information chosen methods provide.

Language: Английский

---

Use of Tox21 screening data to profile PFAS bioactivities on nuclear receptors, cellular stress pathways, and cytochrome p450 enzymes

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134642 - 134642

Published: May 17, 2024

Per- and poly-fluoroalkyl substances (PFAS) are synthetic chemicals widely used in commercial products. PFAS a global concern due to their persistence the environment extensive associations with adverse health outcomes. While legacy have been extensively studied, many non-legacy lack sufficient toxicity information. In this study, we first analyzed bioactivity of using Tox21 screening data surveying more than 75 assay endpoints (e.g., nuclear receptors, stress response, metabolism) understand investigate potential new targets PFAS. From analysis, confirmed several known targets/pathways identified novel To confirm effect on these targets/pathways, conducted cell- enzyme-based assays follow-up studies. We found inhibited cytochromes P450s (CYPs), especially CYP2C9 IC

Language: Английский

---

Per- and polyfluoroalkyl substances (PFAS) measured in seafood from a cross-section of retail stores in the United States

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 459, P. 132062 - 132062

Published: July 13, 2023

Language: Английский

---

Identification and quantification of per- and polyfluorinated alkyl substances (PFAS) migrating from food contact materials (FCM)

Chemosphere, Journal Year: 2024, Volume and Issue: 360, P. 142360 - 142360

Published: May 16, 2024

Per- and polyfluorinated alkyl substances (PFAS) can be added to food contact materials (FCM) increase their water and/or grease repellent properties. Some well-known PFAS are perfluoroalkyl carboxylic acids (PFCA), sulfonic (PFSA), telomer alcohols (FTOH). Due the strength of carbon-fluorine bond, chemically very stable highly resistant biological degradation, posing a risk human health environment. To examine presence in paper-based FCM, various samples were collected, including popcorn bags, muffin cups, pizza boxes with high total organic fluorine (TOF) content from Danish Spanish markets. The FCM composition was characterised by FTIR. Quantification some such as PFCA, PFSA, FTOH performed simulants using LC-MS/MS, addition non-targeted screening approach LC-Orbitrap-HRMS. Among analysed samples, highest concentrations found cup made cellulose (PFCA ∼ 1.41 μg kg

Language: Английский

---

Polyfluoroalkyl phosphate esters (PAPs) as PFAS substitutes and precursors: An overview

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 464, P. 133018 - 133018

Published: Nov. 16, 2023

Language: Английский

---

Non-targeted analysis of per- and polyfluorinated substances in consumer food packaging

Chemosphere, Journal Year: 2024, Volume and Issue: 360, P. 142436 - 142436

Published: May 24, 2024

Language: Английский

---