Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(21)
Published: Feb. 7, 2024
Single-atom
nanozymes
(SAzymes)
showcase
not
only
uniformly
dispersed
active
sites
but
also
meticulously
engineered
coordination
structures.
These
intricate
architectures
bestow
upon
them
an
exceptional
catalytic
prowess,
thereby
captivating
numerous
minds
and
heralding
a
new
era
of
possibilities
in
the
biomedical
landscape.
Tuning
microstructure
SAzymes
on
atomic
scale
is
key
factor
designing
targeted
with
desirable
functions.
This
review
first
discusses
summarizes
three
strategies
for
their
impact
reactivity
biocatalysis.
The
effects
choices
carrier,
different
synthesis
methods,
modulation
first/second
shell,
type
number
metal
centers
enzyme-like
activity
are
unraveled.
Next,
attempt
made
to
summarize
biological
applications
tumor
therapy,
biosensing,
antimicrobial,
anti-inflammatory,
other
from
mechanisms.
Finally,
how
designed
regulated
further
realization
diverse
reviewed
prospected.
It
envisaged
that
comprehensive
presented
within
this
exegesis
will
furnish
novel
perspectives
profound
revelations
regarding
SAzymes.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(20), P. 12639 - 12671
Published: May 8, 2024
Since
the
discovery
of
ferromagnetic
nanoparticles
Fe3O4
that
exhibit
enzyme-like
activity
in
2007,
research
on
nanoenzymes
has
made
significant
progress.
With
in-depth
study
various
and
rapid
development
related
nanotechnology,
have
emerged
as
a
promising
alternative
to
natural
enzymes.
Within
nanozymes,
there
is
category
metal-based
single-atom
nanozymes
been
rapidly
developed
due
low
cast,
convenient
preparation,
long
storage,
less
immunogenicity,
especially
higher
efficiency.
More
importantly,
possess
capacity
scavenge
reactive
oxygen
species
through
mechanisms,
which
beneficial
tissue
repair
process.
Herein,
this
paper
systemically
highlights
types
metal
their
catalytic
recent
applications
repair.
The
existing
challenges
are
identified
prospects
future
composed
metallic
nanomaterials
proposed.
We
hope
review
will
illuminate
potential
repair,
encouraging
sequential
clinical
translation.
ACS Sensors,
Journal Year:
2024,
Volume and Issue:
9(8), P. 3840 - 3847
Published: July 31, 2024
Single-atom
nanozymes
(SANs)
have
become
a
breakthrough
in
atomically
precise
catalysis,
which
relies
on
the
catalytic
active
site
formed
by
single-atom
itself.
From
this
angle,
SANs
and
their
advantages
compared
to
natural
enzymes
as
well
spaces
for
application
are
emphasized.
The
outstanding
control
over
activities;
is
with
bulk
materials
enzymes.
structure
of
has
very
promising
potential
next
generation
biosensing
biomedical
devices
environmental
remediation.
Although
capabilities
high,
difficulties
still
arise.
specificity,
scalability,
biosafety,
catalysis
mechanisms
raise
additional
issues
that
require
further
research.
We
build
up
vision
perspectives
better
implementation
SANs,
designed
diagnostic
purposes,
improving
industrial
technologies,
creating
new
sustainable
technologies
food
processing
industry.
AI
machine
learning
systems
may
clarify
structure–performance
relationship
improved
material
process
selectivity.
future
promising,
addressing
these
challenges
leveraging
advancements
artificial
intelligence
science,
powerful
tools
future.
Small,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 16, 2025
Nanozyme-based
colorimetric
sensors
are
promising
approaches
for
environmental
monitoring,
food
safety,
and
medical
diagnostics.
However,
developing
novel
nanozymes
that
exhibit
high
catalytic
activity,
good
dispersion
in
aqueous
solution,
sensitivity,
selectivity,
stability
is
challenging.
In
this
study,
the
first
time,
single-atom
iridium-doped
carbon
dot
(SA
Ir-CDs)
synthesized
via
a
simple
situ
pyrolysis
process.
Doping
dots
with
iridium
form
of
single
atoms
to
achieve
maximum
atomic
utilization
not
only
enhances
peroxidase
(POD)-like
activity
178.81
U
mg-1
but
also
improves
dispersibility
solutions
over
30
days.
Hence,
SA
Ir-CD
platform
developed
mercury
ions
(Hg2+)
detection
exhibited
linear
relationship
from
0.01
10
µm
limit
4.4
nm.
Notably,
changes
color
can
be
observed
through
naked
eye
smartphone,
enabling
convenient
field
onsite
monitoring
without
need
sophisticated
analytical
equipment.
an
approach
fabricating
metal-based
POD-like
developed,
new
effective
easy-to-use
sensor
Hg2+
constructed.
ACS Materials Au,
Journal Year:
2025,
Volume and Issue:
5(2), P. 377 - 384
Published: Jan. 31, 2025
Single-atom
nanozymes
(SANs)
are
a
class
of
with
metal
centers
that
mimic
the
structure
metalloenzymes.
Herein,
we
report
synthesis
Zn–N–C
SAN,
which
mimics
action
natural
carbonic
anhydrase
enzyme.
The
two-step
annealing
technique
led
to
content
more
than
18
wt
%.
Since
act
as
active
sites,
this
high
loading
resulted
in
superior
catalytic
activity.
Zn-SAN
showed
CO2
uptake
2.3
mmol/g
and
final
conversion
bicarbonate
91%.
was
converted
via
biomimetic
process
by
allowing
its
adsorption
catalyst,
followed
addition
catalyst
HEPES
buffer
(pH
=
8)
start
into
HCO3–.
Afterward,
CaCl2
added
form
white
CaCO3
precipitate,
then
filtered,
dried,
weighed.
Active
carbon
MCM-41
were
used
controls
under
same
reaction
conditions.
According
findings,
sequestration
capacity
42
mg
CaCO3/mg
Zn-SAN.
Some
amino
acids
(AAs)
binding
affinity
for
Zn
able
suppress
enzymatic
activity
blocking
centers.
This
strategy
detection
His,
Cys,
Glu,
Asp
limits
0.011,
0.031,
0.029,
0.062
μM,
respectively,
hence
utilized
quantifying
these
AAs
commercial
dietary
supplements.
