Childhood neglect, the neglected trauma. A systematic review and meta-analysis of its prevalence in psychiatric disorders. DOI Creative Commons
Rosana Carvalho Silva, Francesco Oliva, Sergio Barlati

et al.

Psychiatry Research, Journal Year: 2024, Volume and Issue: 335, P. 115881 - 115881

Published: March 28, 2024

Traumatic events increase risk of mental illnesses, but childhood neglect prevalence in psychiatric disorders is understudied. This systematic review and meta-analysis assessed prevalence, including emotional (EN) physical (PN), among adults with disorders. We conducted a search 122 studies assessing different Prevalence was 46.6% (95%CI[34.5;59.0]) for unspecified (Ne), 42.7% (95%CI[38.4;47.0]) EN, 34.4% (95%CI[30.2;38.8]) PN. Although moderating effect the diagnostic category not confirmed, some clinical diagnoses had significantly lower rates than others. Patients bipolar major depressive disorder showed both EN PN, whereas were found mixed eating PN only. Neglect assessment significant moderator Ne Higher age slightly increased prevalence. Heterogeneity levels within between categories remained high. first examining diverse types considering diagnoses. Our results explore its subtypes disorders, contributing to better understand nuanced interplay specific conditions, guiding effective interventions affected individuals.

Language: Английский

Recognizing the importance of childhood maltreatment as a critical factor in psychiatric diagnoses, treatment, research, prevention, and education DOI Creative Commons
Martin H. Teicher, Jeoffry B. Gordon, Charles B. Nemeroff

et al.

Molecular Psychiatry, Journal Year: 2021, Volume and Issue: 27(3), P. 1331 - 1338

Published: Nov. 4, 2021

Childhood maltreatment is the most important preventable risk factor for psychiatric disorders. Maltreated individuals typically develop disorders at an earlier age, have a more pernicious course, comorbidities, greater symptom severity, and respond less favorably to treatments than non-maltreated with same primary DSM-5 diagnosis. Furthermore, maltreated alterations in stress-susceptible brain regions, hypothalamic-pituitary-adrenal response, inflammatory marker levels not discernible their counterparts. Hence, diagnoses appear be clinically neurobiologically distinct. The failure embody this distinction has interfered our ability discover novel treatments, recommend currently available likely efficacious, been largely unrecognized confound that thwarted identify biological basis major Incorporating into DSM will help transform sign symptom-based classification system etiologically informed nosology. We discuss several diagnostic alternatives inclusion of Developmental Trauma Disorder diagnosis severely dysregulated individuals, all ages, numerous who experienced interpersonal victimization disruptions attachment, such as emotional or neglect. For affected we suggest using conventional categories, depression, but essential modifier indicating history childhood maltreatment, early life stress, delineate ecophenotypic variant. Implementing strategy should improve effectively diagnose treat accelerate discovery.

Language: Английский

Citations

209
Intergenerational effects of childhood maltreatment: A systematic review of the parenting practices of adult survivors of childhood abuse, neglect, and violence DOI
Carolyn A. Greene, Lauren D Haisley, Cara Wallace

et al.

Clinical Psychology Review, Journal Year: 2020, Volume and Issue: 80, P. 101891 - 101891

Published: July 23, 2020

Language: Английский

Citations

204
The effects of early life adversity on children’s mental health and cognitive functioning DOI Creative Commons
Mark Wade, Liam Wright, Katherine E. Finegold

et al.

Translational Psychiatry, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 10, 2022

Emerging evidence suggests that partially distinct mechanisms may underlie the association between different dimensions of early life adversity (ELA) and psychopathology in children adolescents. While there is minimal types ELA are associated with specific outcomes, unique cognitive socioemotional consequences increase transdiagnostic risk mental health problems across internalizing externalizing spectra. The current review provides an overview recent findings examining (e.g., language, executive function), attention bias, emotion regulation), correlates along threat/harshness, deprivation, unpredictability. We underscore similarities differences connecting to particular identify gaps future directions help clarify inconsistencies literature. This focuses on childhood adolescence, periods exquisite neurobiological change sensitivity environment. utility dimensional models better understanding mechanistic pathways towards expression discussed, supporting value such developmental sequelae ELA. Integration existing focused psychiatric classification biobehavioral advance our etiology, phenomenology, treatment difficulties youth.

Language: Английский

Citations

85
Type and dose-response effect of adverse childhood experiences in predicting depression: A systematic review and meta-analysis DOI
Minghui Tan, Ping Mao

Child Abuse & Neglect, Journal Year: 2023, Volume and Issue: 139, P. 106091 - 106091

Published: Feb. 12, 2023

Language: Английский

Citations

57
Burden of Mental Disorders and Suicide Attributable to Childhood Maltreatment DOI
Lucinda Grummitt, Jessie R. Baldwin,

Johanna Lafoa’i

et al.

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(8), P. 782 - 782

Published: May 8, 2024

The proportion of mental disorders and burden causally attributable to childhood maltreatment is unknown.

Language: Английский

Citations

25
The State of Our Understanding of the Pathophysiology and Optimal Treatment of Depression: Glass Half Full or Half Empty? DOI
Charles B. Nemeroff

American Journal of Psychiatry, Journal Year: 2020, Volume and Issue: 177(8), P. 671 - 685

Published: Aug. 1, 2020

Major depressive disorder is a remarkably common and often severe psychiatric associated with high levels of morbidity mortality. Patients major depression are prone to several comorbid conditions, including posttraumatic stress disorder, anxiety disorders, obsessive-compulsive substance use medical cardiovascular disease, diabetes, stroke, cancer, which, coupled the risk suicide, result in shortened life expectancy. The goal this review provide an overview our current understanding depression, from pathophysiology treatment. In spite decades research, relatively little known about its pathogenesis, other than that largely defined by combination ill-defined genetic environmental factors. Although we know female sex, history childhood maltreatment, family as well more recent stressors factors, precisely how these influences interact vulnerability remains obscure. years, considerable advances have been made beginning understand substrates underlie disease vulnerability, interaction genes, early-life adversity, epigenome influencing gene expression now being intensively studied. role inflammation immune system dysfunction pathogenesis also investigated. Brain imaging studies provided firmer circuitry involved providing potential new therapeutic targets. Despite broad armamentarium for antidepressants, evidence-based psychotherapies, nonpharmacological somatic treatments, host augmentation strategies, sizable percentage patients remain nonresponsive or poorly responsive available treatments. Investigational agents novel mechanisms action under active study. Personalized medicine psychiatry provides hope escape standard trial-and-error approach treatment, moving refined method augurs era clinicians alike.

Language: Английский

Citations

128
Childhood maltreatment and adult mental disorders – the prevalence of different types of maltreatment and associations with age of onset and severity of symptoms DOI

Nele Struck,

Axel Krug, Dilara Yüksel

et al.

Psychiatry Research, Journal Year: 2020, Volume and Issue: 293, P. 113398 - 113398

Published: Aug. 30, 2020

Language: Английский

Citations

92
Neurostructural traces of early life adversities: A meta-analysis exploring age- and adversity-specific effects DOI Creative Commons

Tania M. Pollok,

Anna Kaiser,

Eline J. Kraaijenvanger

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104589 - 104589

Published: Feb. 18, 2022

Language: Английский

Citations

47
The prevalences, changes, and related factors of child maltreatment during the COVID-19 pandemic: A systematic review DOI Open Access
Ning Huang, Fan Yang, Xiaohan Liu

et al.

Child Abuse & Neglect, Journal Year: 2022, Volume and Issue: 135, P. 105992 - 105992

Published: Dec. 16, 2022

Language: Английский

Citations

40
Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis DOI Creative Commons
Natalia E. Fares‐Otero, Michele De Prisco, Vincenzo Oliva

et al.

Acta Psychiatrica Scandinavica, Journal Year: 2023, Volume and Issue: 148(2), P. 142 - 164

Published: April 27, 2023

Abstract Objective Childhood maltreatment has been linked to impairments in social functioning and cognition adults with affective disorders. However, conclusions have limited by inconsistent findings across different subtypes domains. We conducted a systematic review meta‐analysis quantify associations between childhood (overall ‐ physical, emotional and/or sexual abuse, physical neglect) domains of disorders (bipolar disorder or major depressive disorder). also examined effect moderators mediators these associations. Methods A search was performed on 12.12.2022 which identified 29 studies included qualitative synthesis ( n = 3022 individuals disorders), 27 2957) were pooled meta‐analyses. Across studies, five examined, four two had sufficient data for (PROSPERO CRD42022288976). Results Social functioning: associated lower global r −0.11 −0.20), poorer interpersonal relations −0.18 −0.33), aggressive behaviour 0.20–0.29) but unrelated vocational functioning. Emotional abuse neglect showed the largest magnitudes effect. cognition: there no meta‐analytic evidence Exploratory moderation analyses did not identify any consistent moderators. Narrative attachment style as possible moderator, sensory patterns, anxiety, symptoms outcomes. Overall, available limited, particularly relation cognition. Conclusions Adults are at risk difficulties after exposure, an observed multiple subtypes, domains, diagnoses. Addressing problems may benefit maltreated both bipolar disorder.

Language: Английский

Citations

33