Immune regulation by fermented milk products: the role of the proteolytic system of lactic acid bacteria in the release of immunomodulatory peptides

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(28), P. 10498 - 10516

Published: June 21, 2023

Food allergies have emerged as a pressing health concern in recent years, largely due to food resources and environmental changes. Dairy products fermented by lactic acid bacteria play an essential role mitigating allergic diseases. Lactic been found possess distinctive proteolytic system comprising cell envelope protease (CEP), transporter system, intracellular peptidase. Studying the impact of different Lactobacillus systems on destruction milk allergen epitopes their potential alleviate allergy symptoms releasing peptides containing immune regulatory properties is valuable auspicious research approach. This paper summarizes species bacteria, especially correlation between CEPs from allergens. Furthermore, mechanism immunomodulatory peptide release was also concluded. Finally, further will provide additional clinical evidence for possible treatment and/or prevention diseases with specific milk/dairy future.

Language: Английский

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Functional proteins in breast milk and their correlation with the development of the infant gut microbiota: a study of mother-infant pairs

Frontiers in Microbiology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 13, 2023

Proteins in breast milk play an important role the growth and development of infants. This study aims to explore correlation between functional proteins infant gut microbiota. Twenty-three mothers their infants were enrolled samples fecal collected. Breast protein content was determined by UPLC-MS/MS, 16S rRNA sequencing employed analyze microbiota infant. The results indicated that secretory immunoglobulin A (sIgA) positively correlated with abundance Veillonella parvula. κ-casein Clostridium butyricum. osteopontin (OPN) lactalbumin contents Parabacteroides distasonis at 42 days. Functional pathway analysis showed OPN significantly amino acid, pyruvate, propionic linoleic alpha-linolenic acid metabolic pathways early life. this suggest specific can influence certain microbes infants, playing immune development.

Language: Английский

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Anti-Inflammatory and Anti-Allergic Properties of Colostrum from Mothers of Full-Term and Preterm Babies: The Importance of Maternal Lactation in the First Days

Nutrients, Journal Year: 2023, Volume and Issue: 15(19), P. 4249 - 4249

Published: Oct. 2, 2023

Our narrative review focuses on colostrum components, particularly those that influence the neonatal immune system of newborns. Colostrum is secreted in small volumes by alveolar cells breast during first two to five days after birth. poor fat and carbohydrates, with larger protein bioactive compounds than mature milk. It plays a crucial role driving neonates’ immunity, transferring immunological factors which help correct development support establishing healthy gut microbiome. The newborn has an innate adaptive deficiency, consequent increase infection susceptibility. In particular, neonates born prematurely have reduced competencies due earlier break maternal trans-placenta transfer such as IgG antibodies. Moreover, pregnancy, starting from second trimester, are conveyed fetus persist quantities post-natal, whereby this known microchimerism (MMc). Thus, preterm newborns deficient heritage, their own under-developed, but can compensate for lack. Early breastfeeding, should be strongly encouraged mothers full-term babies, provides immunomodulant act support, allowing face needs, including fronting infections tolerance. making aware administering helps infants building beneficial sustain them difficult post-partum period.

Language: Английский

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Understanding the Immunological Quality of Breast Milk in Maternal Overweight and Obesity

Nutrients, Journal Year: 2023, Volume and Issue: 15(24), P. 5016 - 5016

Published: Dec. 5, 2023

Maternal obesity, affecting many pregnant women globally, not only poses immediate health risks but also modulates breast milk composition. Obesity is linked to inflammation and oxidative stress, impacting milk's immune properties. This paper explores the intricate relationship between maternal metabolic disorders, such as immunological components. We conducted a thorough search for original review articles published until 17 October 2023 in PUBMED/Scopus database. included several terms related human milk, properties, obesity. Articles were selected with consensus of all authors. disorders have discernible effects on composition immune-related components immunoglobulins, lactoferrin, leptin, ghrelin, adiponectin, C-reactive protein, growth factors, extracellular vesicles, lymphocytes. These changes can significantly impact newborn's system, potential long-term implications beyond postnatal period. critical factor shaping trajectory neonate through breastfeeding, although full advantages breastfeeding children mothers obesity remain uncertain. Ongoing research aims understand unravel these links.

Language: Английский

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Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Vaccine efficacy determined within the controlled environment of a clinical trial is usually substantially greater than real-world vaccine effectiveness. Typically, this results from reduced protection immunologically vulnerable populations, such as children, elderly individuals and people with chronic comorbidities. Consequently, these high-risk groups are frequently recommended tailored immunisation schedules to boost responses. In addition, diverse healthy adults may also be variably protected by same regimen. Current population-based vaccination strategies that consider basic parameters offer glimpse into what achievable if more nuanced aspects immune response considered in design. To date, development has been largely empirical. However, next-generation approaches require rational strategies. We foresee generation precision vaccines mechanistic basis variations associated both immunogenetic baseline health differences. Recent efforts have highlighted importance balanced extra-neutralising antibody functions for vaccine-induced protection. significant modulation polyfunctional responses mediate neutralisation effector observed. Here, we review current understanding key genetic inflammatory modulators polyfunctionality affect outcomes how knowledge harnessed tailor design improved public health.

Language: Английский

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