Maternal gastrointestinal microbiome shapes gut microbial function and resistome of newborns in a cow-to-calf model DOI Creative Commons

Yimin Zhuang,

Shuai Liu, Duo Gao

et al.

Microbiome, Journal Year: 2024, Volume and Issue: 12(1)

Published: Oct. 22, 2024

The maternal gut microbiome is the direct and important source of early colonization development neonatal microbiome. However, differences in unique shared features between mothers with different physiological phenotypes their newborns still lack exhaustive investigation. Here, using a cow-to-calf model, comprehensive investigation was conducted to elucidate pattern characterization microbial transfer from offspring. microbiota rumen feces dairy cows were divided into two clusters via enterotype analysis. distinguished by Prevotella had better production performance, whereas no difference observed classified enterotype. Furthermore, through pairwise combination fecal ruminal enterotypes, we screened group excellent phenotypes. gastrointestinal microbiomes offspring differed significantly. more for meconium than feces. Transmission beneficial bacteria mother observed. Additionally, inherits advantageous metabolic functions rumen. resistome rumen, feces, consistent, abundance calves showed an expanding trend. interaction antibiotic-resistance genes mobile genetic elements most remarkable. diversity core metabolites stable not affected specific varied greatly. Our study demonstrates taxa, function, characteristics microbiomes, reveals potential vertical transmission model. These findings provide new insights transgenerational

Language: Английский

A systematic framework for understanding the microbiome in human health and disease: from basic principles to clinical translation DOI Creative Commons

Ziqi Ma,

Tao Zuo, Norbert Frey

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Sept. 23, 2024

Language: Английский

Citations

26
Role of breastfeeding in disease prevention DOI Creative Commons
A Masi, Christopher J. Stewart

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(7)

Published: June 30, 2024

Human milk provides the infant with many bioactive factors, including immunomodulating components, antimicrobials and prebiotics, which modulate microbiome immune system maturation. As a result, breastfeeding can impact health from infancy, through adolescence, into adulthood. From protecting infections, to reducing risk of obesity, type 1 diabetes childhood leukaemia, positive outcomes are observed in infants receiving breastmilk. For mother, protects against postpartum bleeding depression, increases weight loss, long-term lowers 2 diabetes, breast ovarian cancer, cardiovascular diseases. Beyond mothers, wider society is also impacted because avoidable costs relating morbidity mortality derived lack human exposure. In this review, Medline was used search for relevant articles discuss benefits its societal before exploring future recommendations enhance our understanding mechanisms behind breastfeeding's effects promote on global scale.

Language: Английский

Citations

18
Breastfeeding and Health Benefits for the Mother-Infant Dyad: A Perspective on Human Milk Microbiota DOI Creative Commons
Ener Çağrı Dinleyici

Annals of Nutrition and Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 13

Published: Feb. 6, 2025

Background:: Current scientific research on breastfeeding provides substantial evidence of its numerous positive impacts, not only for children in both the short and long term but also mothers who engage breastfeeding. Summary:: In addition to gold standard effect human milk infant nutrition, is associated with a lower incidence infections, reduced infant/childhood mortality, necrotizing enterocolitis, obesity during childhood later life, better cognitive performance, higher IQ score. For mothers, prolongs lactational amenorrhea, may facilitate postpartum weight loss, reduce breast ovarian cancers cardiovascular diseases. Breastfeeding can play beneficial role preventing antibiotic resistance, which global concern across all age groups. Implementing exclusive infants has potential enhance child development decrease healthcare expenses, leading economic savings individual families society. Human biologically active food that functions as prebiotic probiotic because oligosaccharides composition microbiota, act synergistic synbiotics.

Language: Английский

Citations

5
Clinical translation of microbiome research DOI
Jack A. Gilbert, Meghan B. Azad, Fredrik Bäckhed

et al.

Nature Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Language: Английский

Citations

3
Clinical implications of maternal multikingdom transmissions and early-life microbiota DOI Creative Commons

Shuqin Zeng,

Meicen Zhou, Dezhi Mu

et al.

The Lancet Microbe, Journal Year: 2025, Volume and Issue: unknown, P. 101042 - 101042

Published: Jan. 1, 2025

SummaryMother-to-infant transmission of the bacteriome, virome, mycobiome, archaeome, and their mobile genetic elements has been recognised in nature as an important step for infant to acquire maintain a healthy early-life (from birth till age 3 years) microbiota. A comprehensive overview other maternal multikingdom transmissions remains unavailable, except that bacteriome. Associations between microorganisms diseases throughout human life span have gradually discovered; however, whether these are maternally derived how they concomitantly interact with microbial counterparts remain poorly understood. This Review first discusses current understanding transmissions, contributions development microbiota, primary factors influence processes. The clinical implications inherited microbiota on health early emphasised upon next, along highlighting knowledge gaps should be addressed future research. Finally, interventions restore typical vertical or disturbed discussed potential therapeutic approaches.

Language: Английский

Citations

2
The ins and outs of innate and adaptive type 2 immunity DOI Creative Commons
Ari B. Molofsky, Richard M. Locksley

Immunity, Journal Year: 2023, Volume and Issue: 56(4), P. 704 - 722

Published: April 1, 2023

Type 2 immunity is orchestrated by a canonical group of cytokines primarily produced innate lymphoid cells, 2, and their adaptive counterparts, CD4

Language: Английский

Citations

36
Comparative characterization of the infant gut microbiome and their maternal lineage by a multi-omics approach DOI Creative Commons
Tomás Clive Barker‐Tejeda, Elisa Zubeldia‐Varela, Andrea Macías‐Camero

et al.

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: April 8, 2024

Abstract The human gut microbiome establishes and matures during infancy, dysregulation at this stage may lead to pathologies later in life. We conducted a multi-omics study comprising three generations of family members investigate the early development microbiota. Fecal samples from 200 individuals, including infants (0-12 months old; 55% females, 45% males) their respective mothers grandmothers, were analyzed using two independent metabolomics platforms metagenomics. For metabolomics, gas chromatography capillary electrophoresis coupled mass spectrometry applied. metagenomics, both 16S rRNA gene shotgun sequencing performed. Here we show that greatly vary elders fecal microbiota populations, function, metabolome. Infants have less diverse than adults present differences several metabolite classes, such as short- branched-chain fatty acids, which are associated with shifts bacterial populations. These findings provide innovative biochemical insights into shaping within same generational line could be beneficial improving childhood health outcomes.

Language: Английский

Citations

15
Host and environmental factors shape upper airway microbiota and respiratory health across the human lifespan DOI Creative Commons
Mari-Lee Odendaal, Wouter A. A. de Steenhuijsen Piters, Eelco Franz

et al.

Cell, Journal Year: 2024, Volume and Issue: 187(17), P. 4571 - 4585.e15

Published: Aug. 1, 2024

Our understanding of the normal variation in upper respiratory tract (URT) microbiota across human lifespan and how these relate to host, environment, health is limited. We studied 3,104 saliva (<10 year-olds)/oropharynx (≥10 year-olds) 2,485 nasopharynx samples 3,160 Dutch individuals 0–87 years age, participating a cross-sectional population-wide study (PIENTER-3) using 16S-rRNA sequencing. The composition was strongly related especially nasopharynx, with maturation occurring throughout childhood adolescence. Clear niche- age-specific associations were found between host/environmental factors outcomes. Among others, social interaction, sex, season associated nasopharyngeal microbial community. By contrast, oral more antibiotics, tobacco, alcohol use. present an atlas URT association environment health, establishing baseline for future research.

Language: Английский

Citations

11
Primary succession of Bifidobacteria drives pathogen resistance in neonatal microbiota assembly DOI Creative Commons
Yan Shao, Cristina García-Mauriño, Simon Clare

et al.

Nature Microbiology, Journal Year: 2024, Volume and Issue: 9(10), P. 2570 - 2582

Published: Sept. 6, 2024

Language: Английский

Citations

11
A genome-wide association study reveals the relationship between human genetic variation and the nasal microbiome DOI Creative Commons
Xiaomin Liu, Xin Tong, Leying Zou

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Jan. 30, 2024

Abstract The nasal cavity harbors diverse microbiota that contributes to human health and respiratory diseases. However, whether what extent the host genome shapes microbiome remains largely unknown. Here, by dissecting metagenome data from 1401 healthy individuals, we demonstrated top three genetic principal components strongly correlated with diversity composition. association analyses identified 63 genome-wide significant loci affecting microbial taxa functions, of which 2 reached study-wide significance ( p < 1.7 × 10 -10 ): rs73268759 within CAMK2A associated genus Actinomyces family Actinomycetaceae; rs35211877 near POM121L12 Gemella asaccharolytica . In addition respiratory-related diseases, are mainly implicated in cardiometabolic or neuropsychiatric Functional analysis showed genes were most significantly expressed airway epithelium tissue enriched calcium signaling hippo pathway. Further observational correlation Mendelian randomization consistently suggested causal effects Serratia grimesii Yokenella regensburgei on biomarkers (cystine, glutamic acid, creatine). This study plays an important role shaping microbiome.

Language: Английский

Citations

10