(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

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Review on the biomedical and sensing applications of nanomaterial-incorporated hydrogels

Materials Today Chemistry, Journal Year: 2022, Volume and Issue: 23, P. 100746 - 100746

Published: Jan. 10, 2022

Language: Английский

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Biocompatible carbon quantum dots for intelligent sensing in food safety applications: Opportunities and sustainability

Materials Today Sustainability, Journal Year: 2022, Volume and Issue: 21, P. 100306 - 100306

Published: Dec. 29, 2022

Language: Английский

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Applications of Various Types of Nanomaterials for the Treatment of Neurological Disorders

Nanomaterials, Journal Year: 2022, Volume and Issue: 12(13), P. 2140 - 2140

Published: June 22, 2022

Neurological disorders (NDs) are recognized as one of the major health concerns globally. According to World Health Organization (WHO), neurological main causes mortality worldwide. include Alzheimer’s disease, Parkinson′s Huntington′s Amyotrophic lateral sclerosis, Frontotemporal dementia, Prion Brain tumor, Spinal cord injury, and Stroke. These diseases considered incurable because no specific therapies available cross blood-brain barrier (BBB) reach brain in a significant amount for pharmacological effect brain. There is need development strategies that can improve efficacy drugs circumvent BBB. One promising approaches use different types nano-scale materials. nano-based have ability increase therapeutic effect, reduce toxicity, exhibit good stability, targeted delivery, drug loading capacity. Different shapes nanomaterials been widely used treatment disorders, including quantum dots, dendrimers, metallic nanoparticles, polymeric carbon nanotubes, liposomes, micelles. nanoparticles unique characteristics, sensitivity, selectivity, BBB when nano-sized particles, imaging studies NDs. In this review, we briefly summarized recent literature on various their mechanism action disorders.

Language: Английский

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Recent developments of Red/NIR carbon dots in biosensing, bioimaging, and tumor theranostics

Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 465, P. 143010 - 143010

Published: April 18, 2023

Language: Английский

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Engineering and surface modification of carbon quantum dots for cancer bioimaging

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 149, P. 110433 - 110433

Published: Jan. 20, 2023

Language: Английский

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Nanomaterials for the treatment and diagnosis of Alzheimer's disease: An overview

NanoImpact, Journal Year: 2020, Volume and Issue: 20, P. 100251 - 100251

Published: Aug. 31, 2020

Language: Английский

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Mechanisms for carbon dots-based chemosensing, biosensing, and bioimaging: A review

Analytica Chimica Acta, Journal Year: 2021, Volume and Issue: 1209, P. 338885 - 338885

Published: July 27, 2021

Language: Английский

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Emerging Application of Nanorobotics and Artificial Intelligence To Cross the BBB: Advances in Design, Controlled Maneuvering, and Targeting of the Barriers

ACS Chemical Neuroscience, Journal Year: 2021, Volume and Issue: 12(11), P. 1835 - 1853

Published: May 19, 2021

The blood–brain barrier (BBB) is a prime focus for clinicians to maintain the homeostatic function in health and deliver theranostics brain cancer number of neurological diseases. structural hierarchy situ biochemical signaling BBB neurovascular unit have been primary targets recapitulate into vitro modules. microengineered perfusion systems development 3D cellular organoid culture given major thrust research neuropharmacology. In this review, we on revisiting nanoparticles based bimolecular engineering enable them maneuver, control, target, theranostic payloads across as nanorobots or nanobots. Subsequently provide brief outline specific case studies addressing payload delivery tumor disorders (e.g., Alzheimer's disease, Parkinson's multiple sclerosis, etc.). addition, also address opportunities challenges nanorobots' design. Finally, how computationally powered machine learning (ML) tools artificial intelligence (AI) can be partnered with robotics predict design next generation interact without causing damage, toxicity, malfunctions. content review could references multidisciplinary science clinicians, roboticists, chemists, bioengineers involved cutting-edge pharmaceutical research.

Language: Английский

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Curcumin and Its Derivatives as Theranostic Agents in Alzheimer’s Disease: The Implication of Nanotechnology

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 22(1), P. 196 - 196

Published: Dec. 27, 2020

Curcumin is a polyphenolic natural compound with diverse and attractive biological properties, which may prevent or ameliorate pathological processes underlying age-related cognitive decline, Alzheimer’s disease (AD), dementia, mode disorders. AD chronic neurodegenerative disorder that known as one of the rapidly growing diseases, especially in elderly population. Moreover, being eminent cause posing problems for families, societies well severe burden on economy. There are no effective drugs to cure AD. Although curcumin its derivatives have shown properties can be considered useful inhibiting hallmarks AD, however, they low bioavailability. Furthermore, combat diagnostic therapeutic limitations, various nanoformulations also been recognized theranostic agents enhance pharmacokinetic other bioactive compounds. Nanocarriers beneficial deliver nutritional compounds against blood-brain barrier efficiently distribute them brain. This review spotlights role effectiveness Besides, gut metabolism effects nanoparticles their possible activity discussed.

Language: Английский

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