Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
is
threatening
human
health
due
to
its
resistance
multiple
antibiotics.
Excessive
copper
(Cu)
ions
target
the
lipoylated
proteins
of
tricarboxylic
acid
cycle
cancer
cells,
inducing
proteotoxic
stress
and
their
cuproptosis
death.
Whether
plays
a
part
in
killing
MRSA
by
low‐dose
supplement
Cu
remains
be
explored.
Herein,
Cu‐doped
hydroxyapatite
nanorods
(PC)
are
prepared
on
polyetheretherketone
(PEEK)
resist
infection
improve
PEEK
performance
tissue
integration
with
assistance
near‐infrared
(NIR)
irradiation,
mechanism
against
elucidated.
Mild
photothermal
stimulation
increases
bacterial
membrane
permeability,
accelerating
ions’
intake
consequently
cuproptosis‐like
death
MRSA.
It
confirmed
aggregation
dihydrolipoamide
S‐acetyltrans‐ferase
(DLAT),
deactivation
glutathione
peroxides
4
(GPX4),
destabilization
Fe─S
cluster
ferredoxin
(FDX1)
lipoyl
synthase
(LIAS).
Fortunately,
fibroblast
behaviors
upregulated
NIR‐irradiated
PC.
In
vivo,
PC
NIR
irradiation
exhibits
outstanding
elimination,
reduced
inflammation
response,
improved
biointegration.
Overall,
it
demonstrated
that
can
induced
at
non‐cytotoxic
dose
when
cooperated
mild
heat
stimulus,
this
strategy
has
greatly
promising
application
improving
clinic.
Micromachines,
Journal Year:
2022,
Volume and Issue:
13(9), P. 1395 - 1395
Published: Aug. 26, 2022
With
the
development
of
cross-fertilisation
in
various
disciplines,
flexible
wearable
sensing
technologies
have
emerged,
bringing
together
many
such
as
biomedicine,
materials
science,
control
and
communication
technology.
Over
past
few
years,
multiple
types
devices
that
are
widely
used
for
detection
human
physiological
signals
has
proven
strong
biocompatibility
a
great
potential
further
development.
These
include
electronic
skin
patches,
soft
robots,
bio-batteries,
personalised
medical
devices.
In
this
review,
we
present
an
updated
overview
emerging
sensor
biomedical
applications
comprehensive
summary
research
progress
sensors.
First,
describe
selection
fabrication
their
excellent
electrochemical
properties.
We
evaluate
mechanisms
by
which
these
work,
then
categorise
compare
unique
advantages
variety
from
perspective
vitro
vivo
sensing,
well
some
exciting
body.
Finally,
summarise
opportunities
challenges
field
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(1)
Published: Sept. 15, 2023
Abstract
Methicillin‐resistant
Staphylococcus
aureus
(MRSA)
is
threatening
human
health
due
to
its
resistance
multiple
antibiotics.
Excessive
copper
(Cu)
ions
target
the
lipoylated
proteins
of
tricarboxylic
acid
cycle
cancer
cells,
inducing
proteotoxic
stress
and
their
cuproptosis
death.
Whether
plays
a
part
in
killing
MRSA
by
low‐dose
supplement
Cu
remains
be
explored.
Herein,
Cu‐doped
hydroxyapatite
nanorods
(PC)
are
prepared
on
polyetheretherketone
(PEEK)
resist
infection
improve
PEEK
performance
tissue
integration
with
assistance
near‐infrared
(NIR)
irradiation,
mechanism
against
elucidated.
Mild
photothermal
stimulation
increases
bacterial
membrane
permeability,
accelerating
ions’
intake
consequently
cuproptosis‐like
death
MRSA.
It
confirmed
aggregation
dihydrolipoamide
S‐acetyltrans‐ferase
(DLAT),
deactivation
glutathione
peroxides
4
(GPX4),
destabilization
Fe─S
cluster
ferredoxin
(FDX1)
lipoyl
synthase
(LIAS).
Fortunately,
fibroblast
behaviors
upregulated
NIR‐irradiated
PC.
In
vivo,
PC
NIR
irradiation
exhibits
outstanding
elimination,
reduced
inflammation
response,
improved
biointegration.
Overall,
it
demonstrated
that
can
induced
at
non‐cytotoxic
dose
when
cooperated
mild
heat
stimulus,
this
strategy
has
greatly
promising
application
improving
clinic.
